Time course of degeneration of dopaminergic neurons and respective compensatory processes in the nigrostriatal system in mice

Колачева, А. А.; Козина, Е. А.; Volina, E. V.; Ugryumov, M. V.

doi:10.1134/s0012496614030041

Cited by 9 publications

(11 citation statements)

References 12 publications

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“…Further, an analysis of the expression levels of selected genes was performed at the early stages of the development of PD in the brain tissues and peripheral blood of mice using MPTP-induced models of the early stages of the disease [ 43 ]. Earlier, we obtained data on the expression of the Snca and Drd2 genes in the brain tissues and peripheral blood using the AdvPSS and ESS models of PD [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…We used models of the presymptomatic stage of PD with decapitation of mice 6 h after last injection of MPTP (6 h-PSS), the presymptomatic stage of PD with decapitation of mice 24 h after last injection of MPTP (24 h-PSS), and the advanced presymptomatic (AdvPSS) and early symptomatic (ESS) stages of PD. Models were created as previously described [ 42 , 43 ]. Detailed information is presented in the work performed by our team earlier [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

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Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease

Rudenok

Шадрина

Filatova

et al. 2022

Life

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Processes of intracellular and extracellular transport play one of the most important roles in the functioning of cells. Changes to transport mechanisms in a neuron can lead to the disruption of many cellular processes and even to cell death. It was shown that disruption of the processes of vesicular, axonal, and synaptic transport can lead to a number of diseases of the central nervous system, including Parkinson’s disease (PD). Here, we studied changes in the expression of genes whose protein products are involved in the transport processes (Snca, Drd2, Rab5a, Anxa2, and Nsf) in the brain tissues and peripheral blood of mice with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced models of PD. We detected changes in the expressions of Drd2, Anxa2, and Nsf at the earliest modeling stages. Additionally, we have identified conspicuous changes in the expression level of Anxa2 in the striatum and substantia nigra of mice with MPTP-induced models of PD in its early stages. These data clearly suggest the involvement of protein products in these genes in the earliest stages of the pathogenesis of PD.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease

Rudenok

Шадрина

Filatova

et al. 2022

Life

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“…For the models that were analyzed in this study, it was previously shown that both the death of DAergic neurons and the decrease in the level of dopamine in the striatum are observed even at the earliest time intervals, 6 hours after the introduction of the toxin. At the same time, the first motor impairment was observed only in mice with the MPTP model of ESS 35,36 . The modeling of PD in mice was supplemented with a study of changes in VCP expression levels in humans.…”

Section: Discussionmentioning

confidence: 92%

“…Groups included 6hPSS and 24hPSS (mice were decapitated 6 h and 24 h after MPTP administration, respectively), and AdvPSS and ESS of PD. The models were created as described previously 35,36 . In brief, male mice C57BL/6 8-12 weeks old weighing 22-26 g were used in this study.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, we carried out an analysis of changes in the expression of this gene at the mRNA and protein levels in tissues of mice with a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of the earliest stages of PD 35,36 , as well as in patients with "predicted" PD and in treated and untreated patients at stages 1 and 2 of the Hoehn-Yahr scale.…”

mentioning

confidence: 99%

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VCP expression decrease as a biomarker of preclinical and early clinical stages of Parkinson’s disease

Alieva

Rudenok

Filatova

et al. 2020

Sci Rep

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Valosin-containing human protein (VCP) or p97 performs enzyme functions associated with the maintenance of protein homeostasis and control of protein quality. Disruption of its normal functioning might be associated with the development of Parkinson's disease (PD). Tissues of mice with toxininduced presymptomatic and early symptomatic stages of PD, as well as 52 treated and untreated patients with newly diagnosed PD and nine patients with a "predicted" form of PD, were investigated. Significant changes in Vcp gene expression were observed in almost all studied mouse tissues. A significant decrease in VCP expression specific for PD was also detected at both the late preclinical and the early clinical stages of pD in untreated patients. thus, a decrease in VCP expression is important for changes in the function of the nervous system at early stages of pD. Analysis of changes in VCP expression in all patients with PD and in Vcp in the peripheral blood of mice used as models of pD revealed significant decreases in expression specific for PD. These data suggest that a decrease in the relative levels of VCP mRnA might serve as a biomarker for the development of pathology at the early clinical and preclinical stages of human pD.

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Developing brain as a source of circulating norepinephrine in rats during the critical period of morphogenesis

et al. 2019

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Time course of degeneration of dopaminergic neurons and respective compensatory processes in the nigrostriatal system in mice

Cited by 9 publications

References 12 publications

Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease

Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease

VCP expression decrease as a biomarker of preclinical and early clinical stages of Parkinson’s disease

Developing brain as a source of circulating norepinephrine in rats during the critical period of morphogenesis

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