Time Course of Depression and One‐Year Prognosis of Patients with Stroke in Mainland China

Zhang, Ning; Wang, Chunxue; Wang, An-Xin; Bai, Ying; Zhou, Yong; Wang, Yilong; Zhang, Tong; Zhou, Juan; Yu, Xin; Sun, Xinyu; Liu, Zhaorui; Wang, Wenjuan

doi:10.1111/j.1755-5949.2012.00312.x

Cited by 39 publications

(48 citation statements)

References 36 publications

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“…The time of examination of the relationship between depression and functional recovery may be one reason for the inconsistency. Persistent depression and recurrent depression were found to be the top 2 independent determinants of 1-year outcome after stroke in our previous study, with an OR (95% CI) of 7.615 (5.011–11.572), and 4.701 (2.721–8.122), respectively [4]. Here, we found that the risk of functional impairment (mRS≥2) at 1-year in patients with persistent or recurrent depression was approximately 5 times that of patients with transient depression or without mood disorder.…”

Section: Discussionmentioning

confidence: 79%

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The Relationship between Frontal Lobe Lesions, Course of Post-Stroke Depression, and 1-year Prognosis in Patients with First-Ever Ischemic Stroke

Shi

Xiang

et al. 2014

PLoS ONE

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Background and PurposeMost studies on post-stroke depression (PSD) have focused on a certain time point after stroke instead of the time course of PSD. The aim of this study was to determine the relationship between frontal lobe lesions, course of PSD over a year following the stroke onset, and the 1-year prognosis in patients with first-ever ischemic stroke.MethodsA total of 1067 patients from the prospective cohort study on the incidence and outcome of patients with post stroke depression in China who were diagnosed with first-ever ischemic stroke and attended 4 follow-up visits at 14±2 days, 3 months, 6 months, and 1 year after stroke onset, were enrolled in the study. PSD was diagnosed according to DSM-IV. The course of PSD was divided into the following two categories: persistent/recurrent depression and no/transient depression. Patients with any ischemic lesion responsible for the indexed stroke event located in the frontal lobe were defined as patients with frontal lobe lesions. Modified Rankin Scale (mRS) ≥2 at 1-year was considered to be poor prognosis.ResultsThere were 109 patients with and 958 patients without frontal lobe lesions that formed the frontal lobe (FL) and no-frontal lobe (NFL) groups, respectively. After adjusting for confounding variables, frontal lobe lesion was significantly associated with persistent/recurrent PSD (OR 2.025, 95%CI 1.039–3.949). Overall, 32.7% of patients in the FL group had poor prognosis at 1- year compared with 22.7% in the NFL group (P = 0.021). Compared with no/transient depression, persistent/recurrent depression was found to be an independent predictor of poor prognosis at 1-year both in FL and NFL groups.ConclusionsLong-term and periodical screening, evaluation and treatment are needed for PSD after the onset of ischemic stroke, particularly for patients with frontal lobe infarction.

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Section: Discussionmentioning

confidence: 79%

“…Among the different time courses of PSD, persistent depression and recurrent depression had higher predictive values than transient depression [4].…”

Section: Introductionmentioning

confidence: 86%

The Relationship between Frontal Lobe Lesions, Course of Post-Stroke Depression, and 1-year Prognosis in Patients with First-Ever Ischemic Stroke

Shi

Xiang

et al. 2014

PLoS ONE

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“…: ISRCTN62169508). The details of the PRIOD study have been described elsewhere [10]. Briefly, this large-scale, multi-center study covering 56 hospitals nationwide was conducted between April 2008 and April 2010 to investigate the prevalence of PSD at different time points within the first year after stroke, and the association between PSD and stroke outcomes in stroke survivors in mainland China.…”

Section: Methodsmentioning

confidence: 99%

Depression after minor stroke: Prevalence and predictors

Shi¹,

Xiang²,

Yang³

et al. 2015

Journal of Psychosomatic Research

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“…This 5-year follow-up study of stroke patients is a national project entitled the “Prospective Cohort Study on the Incidence and Outcome of Patients with Post-stroke Depression in China (PRIOD)” [10]. At baseline, patients in 56 hospitals nationwide were consecutively recruited and enrolled if they were aged 18 years or older, had an acute stroke according to WHO criteria [11] confirmed by CT or MRI within 14 days, could complete a clinical interview and provide informed consent.…”

Section: Methodsmentioning

confidence: 99%

The Disability Rate of 5-Year Post-Stroke and Its Correlation Factors: A National Survey in China

et al. 2016

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Few studies on long-term functional outcome have been conducted in post-stroke patients in China. The objective of this study was to conduct a nationwide survey in China to investigate the 5-year prevalence of post-stroke disability and its correlation factors. A total of 893 patients with ischemic stroke were included. Demographic, clinical and neuro-imaging information were collected with standardized instruments that assessed stroke severity, depression, cognitive impairment, stroke recurrence and physical disability. Disability was assessed with the modified Ranking Score (mRS), of which a cutoff score ≥2 indicates disability. Statistical analysis included chi-square tests, two independent samples t-tests, Mann-Whitney U test and multiple logistic regression analysis. The frequency of disability in this study population was 45%. Multivariate analyses revealed that older age, lower education level, previous history of stroke, stroke severity at admission, depression, cognitive impairment at 3 months, and stroke recurrence within 5 years follow up were all significantly associated with post-stroke disability. The disability rate in 5-year post-stroke was high in Chinese patients. Treatment of depression, secondary prevention of stroke and rehabilitation may benefit disabled patients with stroke in China.

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Time Course of Depression and One‐Year Prognosis of Patients with Stroke in Mainland China

Abstract: In our study, depression occurred in >40% of patients within the first year after stroke. Persistent depression is the first independent determinant of prognosis during the first year after stroke.

Cited by 39 publications

References 36 publications

The Relationship between Frontal Lobe Lesions, Course of Post-Stroke Depression, and 1-year Prognosis in Patients with First-Ever Ischemic Stroke

The Relationship between Frontal Lobe Lesions, Course of Post-Stroke Depression, and 1-year Prognosis in Patients with First-Ever Ischemic Stroke

Depression after minor stroke: Prevalence and predictors

The Disability Rate of 5-Year Post-Stroke and Its Correlation Factors: A National Survey in China

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