Time Course of Effects of Testosterone Administration on Sexual Arousal in Women

Tuiten, Adriaan; Honk, Jack van; Koppeschaar, H. P. F.; Bernaards, Coen A.; Thijssen, J. H. H.; Verbaten, Rien

doi:10.1001/archpsyc.57.2.149

Cited by 251 publications

(214 citation statements)

References 45 publications

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“…The middle-aged women first completed a sexual arousal questionnaire (SAQ) (Tuiten et al, 2000), before the first venous blood sample was collected. Thereafter, a nasal dose of testosterone (0.9 mg; Noseafix s ) or placebo was administered in a double-blind, crossover manner.…”

Section: Design and Proceduresmentioning

confidence: 99%

“…Whereas these studies investigated the effects of prolonged testosterone exposure recent studies suggest, that testosterone influences anxiety and sexual behavior also rapidly (Aikey et al, 2002;James and Nyby, 2002). Moreover, a single testosterone administration already increases physiological arousal in response to affective and erotic stimuli in women (Tuiten et al, 2000;van Honk et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

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Testosterone Increases Amygdala Reactivity in Middle-Aged Women to a Young Adulthood Level

Wingen

Zylicz

Pieters

et al. 2008

Neuropsychopharmacol

122

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Testosterone modulates mood and sexual function in women. However, androgen levels decline with age, which may relate to the ageassociated change in sexual functioning and the prevalence of mood and anxiety disorders. These effects of testosterone are potentially mediated by the amygdala. In the present study, we investigated whether the age-related decline in androgen levels is associated with reduced amygdala activity, and whether exogenous testosterone can restore amygdala activity. Healthy young and middle-aged women participated during the early follicular phase of the menstrual cycle, and amygdala responses to biologically salient stimuli were measured with functional magnetic resonance imaging (fMRI). Androgen levels were lower in middle-aged than young women, which was associated with decreased amygdala reactivity. Endogenous testosterone levels correlated positively with amygdala reactivity across the young and middle-aged women. The middle-aged women received a single nasal dose of testosterone in a double-blind, placebocontrolled, crossover manner, which rapidly increased amygdala reactivity to a level comparable to the young women. The enhanced testosterone levels correlated positively with superior frontal cortex responses and negatively with orbitofrontal cortex responses across individuals, which may reflect testosterone-induced changes in amygdala regulation. These results show that testosterone modulates amygdala reactivity in women, and suggest that the age-related decline in androgen levels contribute to the decrease in amygdala reactivity.

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Section: Design and Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Testosterone Increases Amygdala Reactivity in Middle-Aged Women to a Young Adulthood Level

Wingen

Zylicz

Pieters

et al. 2008

Neuropsychopharmacol

122

View full text Add to dashboard Cite

show abstract

“…Interestingly, reductions in behavioral inhibition and anxiety have been found after administrating the steroid hormone testosterone (Svensson et al, 2003). Testosterone arguably exerts these anxiolytic effects through receptor binding in steroid responsive networks located in subcortical structures (Wood, 1996;Tuiten et al, 2000;Van Honk et al, 2001). Since increases in delta (1-3 Hz) synchronization predict reduced anxiety (Hotz et al, 2000), testosterone might in particular influence delta synchronization specifically and thereby affect the coupling between the subcortical lower (i.e.…”

Section: Sirmentioning

confidence: 99%

“…On two testing days, which were separated by three weeks, between 09:00 and 10:00 h, participants received a single sublingually administration of 0.5 mg testosterone (with cyclodextrine as carrier) or placebo. Three hours after intake, see Tuiten et al (2000) for the rationale behind this strategy, a 4-min electroencephalographic (EEG) baseline recording from the frontal, Fp1, Fp2, F3, F4 and Fz electrode sites was obtained (impedance: -5 kV, sampling rate: 250 Hz, amplification: 20 000). Raw EEG data were corrected for horizontal and vertical eye movements using linear regression.…”

Section: Sirmentioning

confidence: 99%

Decoupling of midfrontal delta–beta oscillations after testosterone administration

Schutter¹,

Honk²

2004

International Journal of Psychophysiology

Self Cite

110

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“…Testosterone is associated with an increase in both sexual arousal and aggression in men and women (Glina, 2004;Hermans, Ramsey, & van Honk, 2008;Olweus, Mattson, Schalling, & Low, 1988;Tuiten et al, 2000). Furthermore, most instances of global violence and homicide are perpetrated by young men against other young men (Daly & Wilson, 1988), the same demographic that is disproportionately represented in militaries and coalitional combat units across communities and generations (though most generals, bureaucrats, politicians, leaders, and other "behind the scenes" individuals are usually older; see Browne, Chapter 22, this volume).…”

Section: Puberty and Beyondmentioning

confidence: 99%

Resource Acquisition, Violence, and Evolutionary Consciousness

Gorelik

Shackelford

Weekes–Shackelford

2012

The Oxford Handbook of Evolutionary Perspectives on Violence, Homicide, and War

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The evolution and development of adaptations result from the gradual selection and inheritance of traits and behaviors that better enable organisms to acquire and maintain resources needed for survival and reproduction. We argue that instances of individual, regional, and global violence are rooted in our adaptations to seek, acquire, maintain, and utilize limited resources, regardless of whether such adaptations are currently successful at doing so. However, violence is not the only strategy employed by organisms to acquire resources; cooperation, reciprocity, and social bonding are behaviors that may likewise prove useful in this endeavor. We speculate about how individual adaptations and their by-products may interact with the adaptations of other individuals and with societal and cultural phenomena, both violently and nonviolently. Finally, we discuss how individual decisions can affect higher level regional and global violence. Individual decisions carry moral weight for the individual in question and for society as a whole. We hope to convince readers that their personal decisions and behaviors have far-reaching consequences on the well-being of others and that an evolutionary consciousness may help us to understand the effects of our personal choices on the existence of individual-and group-level violence.

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Time Course of Effects of Testosterone Administration on Sexual Arousal in Women

Abstract: There is a time lag in the effect of sublingually administered testosterone on genital arousal in women. In addition, a consecutive increase in vaginal arousal might cause higher genital sensations and sexual lust.

Cited by 251 publications

References 45 publications

Testosterone Increases Amygdala Reactivity in Middle-Aged Women to a Young Adulthood Level

Testosterone Increases Amygdala Reactivity in Middle-Aged Women to a Young Adulthood Level

Decoupling of midfrontal delta–beta oscillations after testosterone administration

Resource Acquisition, Violence, and Evolutionary Consciousness

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