Time Course of Endothelium-Dependent and -Independent Coronary Vasomotor Response to Coronary Balloons and Stents

Plass, Christian; Sabdyusheva-Litschauer, Inna; Bernhart, Andreas; Samaha, Eslam; Petneházy, Örs; Szentirmai, Eszter; Petrási, Zsolt; Lamin, Victor; Pávó, Noémi; Nyolczas, Noémi; Jakab, András; Murlasits, Zsolt; Bergler‐Klein, Jutta; Maurer, Gerald; Gyöngyösi, Mariann

doi:10.1016/j.jcin.2012.03.021

Cited by 27 publications

(34 citation statements)

References 32 publications

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“…First, stents in general, and DES in particular, have been found to be associated with endothelial dysfunction, both locally and in distal parts of the coronary system, leading to myocardial ischemia and loss of myocardial substrate. 13,14 …”

Section: Discussionmentioning

confidence: 99%

“…6,8–12 Recent reports have postulated that such patients have increased inflammation and endothelial injury, 13–17 and that the grafts in those who have undergone CABG and have pre-existing intracoronary stents may have suboptimal placement and patency. 18 We hypothesized that in diabetic patients with triple-vessel disease, a history of PCI with stent placement portends poorer long-term survival, given the established endothelial dysfunction in diabetic patients 19,20 and the significant CAD burden associated with triple-vessel disease.…”

mentioning

confidence: 99%

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Impact of prior intracoronary stenting on late outcomes of coronary artery bypass surgery in diabetics with triple-vessel disease

Nauffal

Schwann

Yammine

et al. 2015

The Journal of Thoracic and Cardiovascular Surgery

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Objective Recent studies have indicated that coronary artery bypass grafting (CABG) outcomes in patients with prior stents are suboptimal. We aimed to study the impact of prior percutaneous coronary intervention (PCI) with stenting (PCI-S) on late CABG mortality in diabetic patients with triple-vessel disease. Methods We reviewed the primary nonemergency CABG experience from a single U.S. institution (n = 7005; 1996–2007, Toledo, Ohio). Diabetics with triple-vessel disease (n = 1583) were identified and divided into 2 groups: (1) prior PCI-S (n = 202); and (2) no prior PCI (No-PCI [n = 1381]). Hierarchic Cox proportional hazards models were used to assess the effect of prior PCI-S on 5-year mortality after CABG. A propensity score for PCI-S and No-PCI patients was derived using a nonparsimonious logistic regression and used to generate a 1:1 (PCI-S to No-PCI) matched cohort. Results In model 1, after adjusting for preoperative clinical characteristics, medications, off-pump surgery, and isolated CABG surgery status, prior PCI-S was associated with a 39% increased risk of mortality (hazard ratio [HR] = 1.39, with 95% confidence interval [CI; 1.02, 1.90]; P = .04). Further adjustment for date of surgery (model 2) (HR = 1.39, with 95% CI [1.02, 1.91]; P = .04) or operative parameters (model 3) (HR = 1.38, with 95% CI [1.01, 1.88]; P = .046) did not alter the association. The 1:1 matched-cohort analysis confirmed the increased risk associated with PCI-S (HR = 1.61, with 95% CI [1.03, 2.51]; P = .037). Conclusions Patients who have both diabetes and triple-vessel disease, and have undergone prior PCI-S, have poorer long-term outcomes after CABG compared with those who have had no prior PCI-S.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Impact of prior intracoronary stenting on late outcomes of coronary artery bypass surgery in diabetics with triple-vessel disease

Nauffal

Schwann

Yammine

et al. 2015

The Journal of Thoracic and Cardiovascular Surgery

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“…Whilst catheterization on its own (i.e. PTCA) may damage the artery, the addition of balloon inflation and stent deployment may cause a greater degree of injury, resulting in neo-intima thickening [25]. Neo-intima thickening appears to depend on the degree of endothelial denudation [26], a small denuded area results in little intimal hyperplasia [27], while larger denuded areas lead to greater intima thickening [28].…”

Section: What Are the Effects Of Catheter Insertion Balloon Inflatiomentioning

confidence: 99%

“…Impaired endothelium-dependent and -independent dilation, and paradoxical constriction are major functional complications following PTCA and/or PCI in coronary arteries [50,48,25,[51][52][53][54] and in other catheterized arteries [55-58, 16, 59, 17, 60]. The grade of endothelium-dependent dysfunction may depend on the severity of denudation [56], whereas VSMC function appears not to be related with the extent of denudation [48].…”

Section: Functional Changesmentioning

confidence: 99%

Effects of Catheterization on Artery Function and Health: When Should Patients Start Exercising Following Their Coronary Intervention?

2019

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Coronary artery disease (CAD) is a leading cause of death worldwide, and percutaneous transluminal coronary angiography (PTCA) and/or percutaneous coronary intervention (PCI; angioplasty) are commonly used to diagnose and/or treat the obstructed coronaries. Exercise-based rehabilitation is recommended for all CAD patients; however, most guidelines do not specify when exercise training should commence following PTCA and/or PCI. Catheterization can result in arterial dysfunction and acute injury, and given that fact that exercise, particularly at higher intensities, is associated with elevated inflammatory and oxidative stress, endothelial dysfunction and a pro-thrombotic milieu, performing exercise post-PTCA/PCI may transiently elevate the risk of cardiac events. This review aims to summarize extant literature relating to the impacts of coronary interventions on arterial function, including the time-course of recovery and the potential deleterious and/or beneficial impacts of acute versus long-term exercise. The current literature suggests that arterial dysfunction induced by catheterization recovers 4-12 weeks following catheterization. This review proposes that a period of relative arterial vulnerability may exist and exercise during this period may contribute to elevated event susceptibility. We therefore suggest that CAD patients start an exercise-training program between 2 and 4 weeks post-PCI, recognizing that the literature suggest there is a "grey area" for functional recovery between 2-12 weeks post catheterization. The timing of exercise onset should take into consideration the individual characteristics of patients (age, severity of disease, comorbidities) and the intensity, frequency and duration of the exercise prescription.

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“…При цьому, як свідчать дані C. A. Plass і співавт., втрата ендотеліально-залежної вазомоторної функції спостерігається як при імплантації стентів з лікувальним покриттям, так і при використанні ангіографічних балонів з лікувальним покриттям [11].…”

Section: ендотеліальна дисфункція та шляхи її профілактики при проведunclassified

Endothelial Dysfunction and Ways of its Prevention during Percutaneous Coronary Interventions by Recanalization of Coronary Arteries

Aksenov¹

2019

Ukr. ž. med. bìol. sportu

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Time Course of Endothelium-Dependent and -Independent Coronary Vasomotor Response to Coronary Balloons and Stents

Abstract: Coronary arteries treated with plain balloon, DEB, BMS, and DES showed time-dependent loss of endothelial-dependent and -independent vasomotor function, with imbalanced contraction/dilation capacity.

Cited by 27 publications

References 32 publications

Impact of prior intracoronary stenting on late outcomes of coronary artery bypass surgery in diabetics with triple-vessel disease

Impact of prior intracoronary stenting on late outcomes of coronary artery bypass surgery in diabetics with triple-vessel disease

Effects of Catheterization on Artery Function and Health: When Should Patients Start Exercising Following Their Coronary Intervention?

Endothelial Dysfunction and Ways of its Prevention during Percutaneous Coronary Interventions by Recanalization of Coronary Arteries

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