Time course of inulin and creatinine clearance in the interval between two haemodialysis treatments

Olden, R. W. van; Acker, B.A.C. van; Koomen, G. C. M.; Krediet, Raymond T.; Arisz, L.

doi:10.1093/ndt/10.12.2274

Cited by 48 publications

(64 citation statements)

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“…1,21,22 Moist et al 22 showed that the urine of hemodialysis patients was positively correlated with the inulin clearance rate (correlation coefficient: 0.71) and the correlation coefficient of urine for 24 h with the mean of creatinine and urea clearance was 0.57 (p ¼ 0.001). Van Olden et al 23 also observed a significant positive correlation between GFR and urine volume for 24 h. These results support that 24 h urine volume is an effective indicator for the evaluation of RRF. Other studies also used this indicator to define RRF loss (24 h urine < 200 mL).…”

Section: Discussionmentioning

confidence: 60%

Effects of Residual Renal Function on Left Ventricle and Analysis of Related Factors in Patients with Hemodialysis

Ding

2012

Renal Failure

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Background: Left ventricular hypertrophy (LVH) and systolic dysfunction would predict the mortality of patients undergoing maintenance hemodialysis. The cause of LVH is usually related to the increase of total peripheral vascular resistance and overloading volume. The presence of residual diuresis enables greater control of the volume. This study evaluated the effects of residual renal function (RRF) on the left ventricle and analyzed the related factors involved in hemodialysis patients. Methods: A total of 59 hemodialysis patients were classified into two groups. The patients in the RRF (RRFþ) group had a urine volume greater than 200 mL/24 h, and the patients in the non-RRF (RRFÀ) group had a urine volume less than 200 mL/24 h. B-type natriuretic peptide (BNP), blood total homocysteine (tHcy), and blood biochemical indexes were determined for the patients in both groups. Echocardiography and Doppler tests were performed to determine the cardiac indexes. Results: LVH and systolic dysfunction in the RRFþ group were less severe than those in the RRFÀ group. The concentration of tHcy and BNP in patients with RRF was decreased in comparison with those without RRF. The concentration of tHcy and BNP was positively correlated with the residual diuresis. Conclusions: There were distinct ventricular geometric patterns and different functional performances between RRFþ and RRFÀ groups. The presence of residual diuresis had a beneficial effect on the left ventricular function in hemodialysis patients.

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Section: Discussionmentioning

confidence: 60%

Effects of Residual Renal Function on Left Ventricle and Analysis of Related Factors in Patients with Hemodialysis

Ding

2012

Renal Failure

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“…GFR can vary during the interdialytic interval in dialysis patients. 35 We did not standardize the day of the week for clearance measurements which could contribute to underestimation of CL UREA . The relatively large root mean squared error (RMSE)suggests presence of high relative variability (log scale measures variation as a fraction of the absolute value of the gold standard) that is not completely captured by the variables in the estimating equations, highlighting the need to improve estimates for individual prediction and clinical decision making.…”

Section: Discussionmentioning

confidence: 99%

Estimating residual kidney function in dialysis patients without urine collection

Shafi

Michels

Levey

et al. 2016

Kidney International

156

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Residual kidney function contributes substantially to solute clearance in dialysis patients but cannot be assessed without urine collection. We used serum filtration markers to develop dialysis-specific equations to estimate urinary urea clearance without the need for urine collection. In our development cohort, we measured 24-hour urine clearances under close supervision in 44 patients and validated these equations in 826 patients from the Netherlands Cooperative Study on the Adequacy of Dialysis. For the development and validation cohorts, median urinary urea clearance was 2.6 and 2.4 mL/min, respectively. During the 24-hour visit in the development cohort, serum β-trace protein concentrations remained in steady state but concentrations of all other markers increased. In the validation cohort, bias (median measured minus estimated clearance) was low for all equations. Precision was significantly better for β-trace protein and β2-microglobulin equations and the accuracy was significantly greater for β-trace protein, β2-microglobulin and cystatin C equations, compared with the urea plus creatinine equation. Area under the receiver operator characteristic curve for detecting measured urinary urea clearance by equation-estimated urinary urea clearance (both 2 mL/min or more) were 0.821, 0.850 and 0.796 for β-trace protein, β2-microglobulin and cystatin C equations, respectively; significantly greater than the 0.663 for the urea plus creatinine equation. Thus, residual renal function can be estimated in dialysis patients without urine collections.

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“…51 Cr-EDTA: For the 51 Cr-EDTA analysis, blood samples drawn at 5 and 24 hours were used, as previously reported (6,12,13). Dialysate collection ended at the last exchange of dialysate before blood sampling at 24 hours; in most patients, this collection occurred in the morning.…”

Section: Endogenous Substancesmentioning

confidence: 99%

Endogenous Markers for Estimation of Renal Function in Peritoneal Dialysis Patients

et al. 2013

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♦ Objective: This method comparison study, conducted at the peritoneal dialysis (PD) outpatient clinic of the Department of Renal Medicine, Aarhus University Hospital, Denmark, set out to evaluate the accuracy and reproducibility of methods for estimating glomerular filtration rate (GFR) based on endogenous markers in PD patients. ♦ Patients: The 12 consecutive patients included in the study were examined twice while in a stable condition. All patients finished the study. Inclusion criteria were age 18 years or older, ability to collect 24-hour urine, and urine production greater than 300 mL in 24 hours.

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Time course of inulin and creatinine clearance in the interval between two haemodialysis treatments

Cited by 48 publications

References 0 publications

Effects of Residual Renal Function on Left Ventricle and Analysis of Related Factors in Patients with Hemodialysis

Effects of Residual Renal Function on Left Ventricle and Analysis of Related Factors in Patients with Hemodialysis

Estimating residual kidney function in dialysis patients without urine collection

Endogenous Markers for Estimation of Renal Function in Peritoneal Dialysis Patients

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