Time course of lactate clearance in trauma and its relevance to outcomes

Chana,; Manson, Joanna; Davenport, Ross; De'ath, H. D.; Spoors, Catherine; Raza, Imran; Khan, Shahab; Coates, Alan S.; Rourke, Colin; Brohi, Karim

doi:10.1186/1757-7241-20-s1-o9

Cited by 3 publications

(7 citation statements)

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“…Lactate clearance is reported as a predictor of mortality in patients with stable vital signs or volume loss of less quantities 5 6 12 . In this study, these variables were independent, probably due to limited sample, differing from other authors 4 5 7 10 .…”

Section: Discussioncontrasting

confidence: 62%

“…Chana et cols 4 found lower mortality in patients who had greater reduction in their lactate levels, which is a possible way of evaluating the therapeutic instituted in multiple trauma patients.…”

Section: Discussionmentioning

confidence: 93%

“…Hyperlactatemia results from cellular injury and hypoxia, with the ability to demonstrate early cellular suffering, even before the change in vital signs, and assist in screening and pre-hospital treatment 5 . Lactate was used as a predictor in the pre-hospital to need to refer patients to specialist teams in trauma 4 and for early identification of tissue hypoperfusion. High lactate serum levels (>4 mmol/l) also correlated with need for surgical treatment of multiple organ failure and death 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Lactate was used as a predictor in the pre-hospital to need to refer patients to specialist teams in trauma 4 and for early identification of tissue hypoperfusion. High lactate serum levels (>4 mmol/l) also correlated with need for surgical treatment of multiple organ failure and death 4 . In this study, there was no correlation of lactate levels with mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have linked lactate >4 mmol/l as a major criterion of severity and chance of survival, rarely found in stable patients even with comorbidities 6 8 10 . Others show that patients with high blood lactate have higher risk of death compared to those with levels within the normal laboratory range 3 4 . The clearance of lactate may represent good parameter to analyze the quality of resuscitation measures in trauma 10 13 and information on prognosis, especially in early mortality.…”

Section: Introductionmentioning

confidence: 99%

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Lactate as Predictor of Mortality in Polytrauma

Freitas

Franzon

2015

ABCD, arq. bras. cir. dig.

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Background: The lactate is a product of anaerobic metabolism; it can be used as a marker on demand and availability of oxygen. Changes in lactate levels can be effectively used as a marker in resuscitation maneuvers, even in patients with stable vital signs. Aim: To verify the lactate clearance as a predictor of mortality in trauma patients, in need of intensive care. Method: A total of 851 patients were admitted in ICU, in which 146 were victims of multiple trauma; due to the exclusion criteria, were included 117. Results: Patients were 87% male, mean age 32.4 years, motorcycle drivers, Glasgow coma scale between 3-8, affected by cranial trauma, followed by abdominal trauma. Was verified mortality up to 48 h and global mortality, that did not show statistical relationship between lactate clearance and mortality (p=0.928). Conclusion: There is no correlation between admission lactate or lactate clearance and mortality in patients treated with multiple trauma.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lactate as Predictor of Mortality in Polytrauma

Freitas

Franzon

2015

ABCD, arq. bras. cir. dig.

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Evaluation of Lactate and Lactate Clearance as a Marker of Outcome in Trauma ICU

Mishra

Hakim

Mishra

et al. 2020

Asian Journal of Pharmaceutical Research and Health Care

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Hypo-perfusion is usual in patients suffering from traumatic injury that may be indicated by serum lactate elevation. This study was performed to analyze the relation of the lactate value with trauma mortality and its clearance. The research included a total of 202 trauma patients admitted into ICU. Study parameters such as patient demography, injury mechanism, Blood Pressure (BP), heart rate (HR), Glasgow Coma Scale (GCS) and level of lactate in the blood. All these parameters were documented in the first 3 hours of hospitalization, and lactate clearance was recorded between 3 and 9 hours afterwards. For the study point; death up to 7 days was considered as a direct impact of trauma and considered in study. The study was divided into two subgroups, either expired (n=79) or survivors (n=123) according to the final outcome. The mean age, mean body weight, sex ratio, HR, Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) in both groups were comparable. The difference in lactate at admission, lactate at 6 hours and lactate clearance in between survivors and deaths were found to be insignificant statistically. Among trauma patients there is no significant relationship between lactate admission or lactate clearance and mortality. Higher sample size may be appropriate for definitive proof to be reached.

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Lactate Clearance Vs Revised Trauma Score

Attia¹,

Elzehery²,

Ahmed³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Trauma-related deaths are one of the top 10 causes of death. Resuscitation in trauma and critically ill patients are challenging. Clinical and laboratory parameters are used to verify the different measurements. Lactate is a diagnostic and prognostic biomarker in sepsis and trauma. Objective: The aim of the current work was to investigate lactate clearance in patients admitted to emergency department (ED) and compare with the revised trauma score to predict mortality rate in polytrauma patients. Patients and methods: This prospective case-control study included a total of 200 polytraumatic patients with availability of Blood sampling, admitted to Department of Emergency Medicine, Mansoura University Hospitals. This study was conducted over a period of 12 months. Serum lactate was collected in tubes before receiving any type of treatment. The analysis was performed within 1 h from blood collection and six hours. Results: Regarding association with mortality, Lactate first hour, Lactate after 6 hours and Lactate clearance demonstrated significant correlation with it (P<0.05), while the remaining factors were not correlated (P>0.05). Regarding association with incidence of discharge for ICU, type of injury and Revised trauma score were correlated with it (P<0.05). Conclusion:It could be concluded that serum lactate level and lactate clearance could be used as an independent predictor of mortality, incidence of discharge for ICU as well as admission to ICU with comparable efficacy to revised trauma score (RTS) in terms of Triage management.

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Time course of lactate clearance in trauma and its relevance to outcomes

Cited by 3 publications

References 0 publications

Lactate as Predictor of Mortality in Polytrauma

Lactate as Predictor of Mortality in Polytrauma

Evaluation of Lactate and Lactate Clearance as a Marker of Outcome in Trauma ICU

Lactate Clearance Vs Revised Trauma Score

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