Time course of motor and cognitive functions after chronic cerebral ischemia in rats

Damodaran, Thenmoly; Hassan, Zurina; Navaratnam, V.; Mustapha, Muzaimi; Ng, Gandi; Müller, Christian P.; Liao, Ping; Dringenberg, Hans C.

doi:10.1016/j.bbr.2014.09.014

Cited by 42 publications

(27 citation statements)

References 25 publications

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“…F) regardless of the region examined. Importantly, 2VO was previously reported to reduce BDNF levels in the hippocampus (Lee et al ., ; Zheng et al ., ; Damodaran et al ., ; Sakr et al ., ) but at a late stage when neuronal death had already occurred. In our conditions, ischemically injured neurons (shrunken neurons) were not observed after 2VO irrespective of the region examined (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Given that cognition is improved by short‐term physical exercise (Vaynman et al ., ) and deficient at day 10 after 2VO induction (Shu et al ., ; Damodaran et al ., ), the most surprising and unexpected result of this study was that both EX and 2VO resulted in an increase in brain p‐TrkB tyr816 levels. These data raise questions about the reliability of the measurement of brain p‐TrkB tyr816 levels to explore BDNF‐dependent neuroplasticity in rats subjected to 2VO, and raise the possibility that cellular pathways downstream from surface and/or internalized p‐TrkB tyr816 receptors are impaired in 2VO rats.…”

Section: Discussionmentioning

confidence: 97%

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Brain BDNF levels are dependent on cerebrovascular endothelium‐derived nitric oxide

Banoujaafar

Monnier

Pernet

et al. 2016

Eur J of Neuroscience

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Scientific evidence continues to demonstrate a link between endothelial function and cognition. Besides, several studies have identified a complex interplay between nitric oxide (NO) and brain-derived neurotrophic factor (BDNF), a neurotrophin largely involved in cognition. Therefore, this study investigated the link between cerebral endothelium-derived NO and BDNF signaling. For this purpose, levels of BDNF and the phosphorylated form of endothelial NO synthase at serine 1177 (p-eNOS) were simultaneously measured in the cortex and hippocampus of rats subjected to either bilateral common carotid occlusion (n = 6), physical exercise (n = 6) or a combination of both (n = 6) as experimental approaches to modulate flow-induced NO production by the cerebrovasculature. Tropomyosin-related kinase type B (TrkB) receptors and its phosphorylated form at tyrosine 816 (p-TrkB) were also measured. Moreover, we investigated BDNF synthesis in brain slices exposed to the NO donor glyceryl trinitrate. Our results showed increased p-eNOS and BDNF levels after exercise and decreased levels after vascular occlusion as compared to corresponding controls, with a positive correlation between changes in p-eNOS and BDNF (r = 0.679). Exercise after vascular occlusion did not change levels of these proteins. Gyceryl trinitrate increased proBDNF and BDNF levels in brain slices, thus suggesting a possible causal relationship between NO and BDNF. Moreover, vascular occlusion, like exercise, resulted in increased TrkB and p-TrkB levels, whereas no change was observed with the combination of both. These results suggest that brain BDNF signaling may be dependent on cerebral endothelium-derived NO production.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Brain BDNF levels are dependent on cerebrovascular endothelium‐derived nitric oxide

Banoujaafar

Monnier

Pernet

et al. 2016

Eur J of Neuroscience

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“…It has been found that the temporal parietal and prefrontal lobes in the brains of patients with AD exhibit significant atrophy and that there are numerous neurofibrillary tangles in the nerve cells; these observations are associated with microvascular pathological changes ( 12 ). Brain vascular lesions may also cause ischemia and hypoxia, which induce β-amyloid deposition, abnormal phosphorylation of tau protein and neuronal degeneration and death ( 13 ). These findings indicate that there are vascular pathological changes in the brains of individuals with AD, which may contribute to the occurrence and development of the disease.…”

Section: Discussionmentioning

confidence: 99%

Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer’s disease

Zhu

Sun

et al. 2015

Experimental and Therapeutic Medicine

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The aim of the present study was to investigate the potential clinical application of the genetic marker microRNA (miRNA)-210 in the cerebrospinal fluid (CSF) and serum of patients with Alzheimer’s disease (AD). The enrolled patients were divided into the mild cognitive impairment (MCI) and AD groups. Healthy individuals were used as the controls. The mRNA and protein expression of vascular endothelial growth factor (VEGF) in the CSF and serum samples was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis, respectively. The expression of miRNA-210 in the CSF and serum was detected by RT-qPCR. The results revealed that the mRNA and protein expression levels of VEGF in the CSF and serum were decreased in the MCI and AD groups compared with those in the control group. The greater the severity of the dementia, the lower the mRNA and protein expression of VEGF. Similar to the trend observed for VEGF, the miRNA-210 expression in the CSF and serum decreased as the severity of the AD increased. miRNA-210 is thus not only indicative of AD pathogenesis, but may also provide novel insights into the prevention and treatment of the disease.

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“…There are four types of ischemia induction model which are used for spatial memory testing. The first model is permanent global ischemia [53][54][55][56][57][58][59][60][61][62] . In this model, the commencement of the MWM test varied from five, seven, eight, to 15 days before the end of ischemia induction 58,59,61,63 .…”

Section: Discussionmentioning

confidence: 99%

Transient Bilateral Common Carotid Artery Occlusion (tBCCAO) of Rats as a Model of Global Cerebral Ischemia

Handayani

Susilowati

Setyopranoto

et al. 2019

Bangladesh J Med Sci

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Background: Transient bilateral common carotid artery occlusion (tBCCAO) has been performed in rats as a model of global ischemia. However, the technique varied between laboratories and produced difficulties in the comparison of results. Variations such as rat strain, age, ischemic and reperfusion duration could affect the results. This review aims to provide a general overview of the variation of animal strains, duration of tBCCAO, reported cerebral ischemic area produced by tBCCAO, use of TTC staining for measurement of volume of brain ischemia and functional neurological tests. Method: The data of this review were obtained from abstracts in PubMed database and Google Scholars and were not limited by publication time. Keywords used to search the abstracts were (BCCAO OR “bilateral common carotid artery occlusion” OR “stroke” OR “cerebral ischemia” OR “brain ischemia”) AND (rat OR rats). The research method of each study was identified from the collected abstracts. The abstracts were chosen for further study on the basis that they met the inclusion criteria which were English language articles; original research article; animal model used were adolescent, adult, and elderly rats; ischemic finding in rats’ cerebrum by BCCAO technique was presented; ischemic size were assessed and the result was described; studies that had control group; and studies that induced transient global ischemic to the rats’ cerebrum. Data that were extracted to the datasheet were references; animal model strain; ischemic duration; reperfusion duration; ischemic area; 2,3,5 Triphenyltetrazolium Chloride (TTC) staining; Cavalieri method; and rats’ neurological functional tests. Results and Conclusions: There were differences in the ischemic area between Wistar and Sprague-Dawley rats after transient BCCAO. There were differences in the TTC staining solution concentration that was used to identify ischemic area of the brain following transient BCCAO. There was a very limited number of studies using Cavalieri method for the quantification of ischemic volume of rats’ brain after transient BCCAO. Neurological functional tests in animal models post transient BCCAO did not include sensory and memory functions tests. Bangladesh Journal of Medical Science Vol.18(3) 2019 p.491-500

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Time course of motor and cognitive functions after chronic cerebral ischemia in rats

Cited by 42 publications

References 25 publications

Brain BDNF levels are dependent on cerebrovascular endothelium‐derived nitric oxide

Brain BDNF levels are dependent on cerebrovascular endothelium‐derived nitric oxide

Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer’s disease

Transient Bilateral Common Carotid Artery Occlusion (tBCCAO) of Rats as a Model of Global Cerebral Ischemia

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