Time-course of “off-line” prefrontal rTMS effects — a PET study

Eisenegger, Christoph; Treyer, Valérie; Fehr, Ernst; Knoch, Daria

doi:10.1016/j.neuroimage.2008.04.172

Cited by 98 publications

(70 citation statements)

References 43 publications

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“…In total, the 16 ultimatum games lasted approximately 6 min. The responders' decisions in the 16 games were thus well within the borders of the rTMS aftereffect 47 .…”

Section: Methodsmentioning

confidence: 62%

Dorsolateral and ventromedial prefrontal cortex orchestrate normative choice

et al. 2011

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Humans are noted for their capacity to over-ride self-interest in favor of normatively valued goals. We examined the neural circuitry that is causally involved in normative, fairness-related decisions by generating a temporarily diminished capacity for costly normative behavior, a 'deviant' case, through non-invasive brain stimulation (repetitive transcranial magnetic stimulation) and compared normal subjects' functional magnetic resonance imaging signals with those of the deviant subjects. When fairness and economic self-interest were in conflict, normal subjects (who make costly normative decisions at a much higher frequency) displayed significantly higher activity in, and connectivity between, the right dorsolateral prefrontal cortex (DLPFC) and the posterior ventromedial prefrontal cortex (pVMPFC). In contrast, when there was no conflict between fairness and economic self-interest, both types of subjects displayed identical neural patterns and behaved identically. These findings suggest that a parsimonious prefrontal network, the activation of right DLPFC and pVMPFC, and the connectivity between them, facilitates subjects' willingness to incur the cost of normative decisions.

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“…In total, the 16 ultimatum games lasted approximately 6 min. The responders' decisions in the 16 games were thus well within the borders of the rTMS aftereffect 47 .…”

Section: Methodsmentioning

confidence: 62%

Dorsolateral and ventromedial prefrontal cortex orchestrate normative choice

et al. 2011

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“…The duration of the off-line effects of low frequency rTMS is estimated to be between 60 and 100% of the duration of the stimulation (e.g., Nyffeler et al, 2006;Eisenegger et al, 2008;Chen et al, 1997). This means that we could be rather confident that the effects of inactivation would last between 9-15 minutes of the experimental task following the stimulation of each hemisphere, and that the effects of stimulating one hemisphere would not carry over to performance on the experimental task after stimulating the other hemisphere.…”

Section: Rtms Protocolmentioning

confidence: 99%

Internal modeling of upcoming speech: A causal role of the right posterior cerebellum in non-motor aspects of language production

Runnqvist

Bonnard

Gauvin

et al. 2016

Cortex

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Some language processing theories propose that, just as for other somatic actions, self-monitoring of language production is achieved through internal modeling. The cerebellum is the proposed center of such internal modeling in motor control, and the right cerebellum has been linked to an increasing number of language functions, including predictive processing during comprehension.Relating these findings, we tested whether the right posterior cerebellum has a causal role for self-monitoring of speech errors. Participants received 1Hz repetitive transcranial magnetic stimulation during 15 minutes to lobules Crus I and II in the right hemisphere, and, in counterbalanced orders, to the contralateral area in the left cerebellar hemisphere (control) in order to induce a temporary inactivation of one of these zones. Immediately afterwards, they engaged in a speech production task priming the production of speech errors.Language production was impaired after right compared to left hemisphere stimulation, a finding that provides evidence for a causal role of the cerebellum during language production. We interpreted this role in terms of internal modeling of upcoming speech through a verbal working memory process used to prevent errors.

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“…Similar stimulation parameters (i.e., fixed intensity of stimulation, 15 minutes of stimulation) have been used before to suppress activity of prefrontal regions prior to task requiring social judgments (e.g., reciprocal fairness, moral judgments), with the effects of stimulation continuing after the end of the actual stimulation (e.g., Baumgartner, Knoch, Hotz, Eisenegger, & Fehr, 2011;Eisenegger, Treyer, Fehr, & Knoch, 2008;Knoch, Pascual-Leone, Meyer, Treyer, & Fehr, 2006;Tassy et al, 2012). Talairach coordinates (Talairach & Tournoux, 1988) for the dmPFC were x = 1.5, y = 31.5, and z = 35.5; these coordinates were taken from previous neuroimaging work demonstrating an activation of this region during social impression updating (Mende-Siedlecki et al, 2012).…”

Section: Transcranial Magnetic Stimulation (Tms)mentioning

confidence: 99%

Interfering with activity in the dorsomedial prefrontal cortex via TMS affects social impressions updating

Ferrari

Vecchi

Todorov

et al. 2016

Cogn Affect Behav Neurosci

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In our everyday social interactions we often need to deal with others' unpredictable behaviors. Integrating unexpected information in a consistent representation of another agent is a cognitively demanding process. Several neuroimaging studies point to the medial prefrontal cortex (mPFC) as a critical structure in mediating social evaluations. Our aim here was to shed light on the possible causal role of the mPFC in the dynamic process of forming and updating social impressions about others. We addressed this issue by suppressing activity in the mPFC by means of 1 Hz offline transcranial magnetic stimulation (TMS) prior to a task requiring participants to evaluate other agents' trustworthiness after reading about their social behavior. In two different experiments, we found that inhibiting activity in the mPFC increased perceived trustworthiness when inconsistent information about one agent's behavior was provided. In turn, when only negative or positive behaviors of a person were described, TMS over the mPFC did not affect judgments. Our results indicate that the mPFC is causally involved in mediating social impressions updating-at least in cases in which judgment is uncertain due to conflicting information to be processed.

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Time-course of “off-line” prefrontal rTMS effects — a PET study

Cited by 98 publications

References 43 publications

Dorsolateral and ventromedial prefrontal cortex orchestrate normative choice

Dorsolateral and ventromedial prefrontal cortex orchestrate normative choice

Internal modeling of upcoming speech: A causal role of the right posterior cerebellum in non-motor aspects of language production

Interfering with activity in the dorsomedial prefrontal cortex via TMS affects social impressions updating

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