Time course of pro- and anti-inflammatory cytokine levels in patients with burns—Prognostic value of interleukin-10

Csontos, Csaba; Foldi, V.; Pàlinkàs, László; Bogár, Lajos; Röth, Elizabeth; Wéber, György; Lantos, János

doi:10.1016/j.burns.2009.10.009

Cited by 52 publications

(40 citation statements)

References 31 publications

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“…In humans, the prolonged anti-inflammatory effect of IL-10 after tissue injury has been associated with an increased risk of sepsis and mortality. 44 In the present study, IL-10 levels in the SSI and non-SSI groups showed no statistical differences at day +1 or +3. However, P values were as low as .077 at day +1 and .067 at day +3.…”

Section: Discussioncontrasting

confidence: 57%

Early Modification in Drainage of Interleukin-1β and Tumor Necrosis Factor-α Best Predicts Surgical-Site Infection After Cervical Neck Dissection for Oral Cancer

Candau-Alvarez

Gil-Campos²,

Torre-Aguilar³

et al. 2015

Journal of Oral and Maxillofacial Surgery

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Section: Discussioncontrasting

confidence: 57%

Early Modification in Drainage of Interleukin-1β and Tumor Necrosis Factor-α Best Predicts Surgical-Site Infection After Cervical Neck Dissection for Oral Cancer

Candau-Alvarez

Gil-Campos²,

Torre-Aguilar³

et al. 2015

Journal of Oral and Maxillofacial Surgery

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“…Informatively, the data obtained from both BALB/c and C57BL/6 mice could provide insights for clinical settings, because the expression profiles of TNF-α and IL10 change significantly in burn patients compared with healthy persons (26,27). Moreover, the similarities of the changes in gene expression and a number of similar pathways/biogroups between the mouse burn models and human burn conditions also suggest that the mouse model could be used to mimic human responses to inflammation (28,29).…”

Section: The Interfering Role Of Aaag Odn On Irf5mentioning

confidence: 99%

An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-induced Systemic inflammatory Responses by inhibiting interferon Regulatory Factor 5 Pathway

Xiao

et al. 2017

Mol Med

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Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis factor-α (TNF-α) in the injured lungs. However, its underlying mechanisms remain to be elucidated. Upon the bioinformatic analysis revealing that the sequence of AAAG ODN is in consensus with the interferon regulatory factor 5 (IRF5) binding site in the cis-regulatory elements of proinflammatory cytokines, we tried to explore whether AAAG ODN could attenuate burn injury-induced systemic inflammatory responses by inhibiting the IRF5 pathway. Using a mouse model with sterile systemic inflammation induced by burn injury, we found that AAAG ODN prolonged the lifespan of the mice, decreased the expression of IRF5 in the injured skin, reduced the production of TNF-α and IL-6 in the blood and injured skin, and attenuated the ALI. These effects were correlated with AAAG ODN-mediated inhibition of nuclear translocation of IRF5. The data suggest that AAAG ODN could act as a cytoplasmic decoy capable of interfering the function of IRF5 and be developed as a drug candidate for the treatment of inflammatory diseases. online address: http://www.molmed.org

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“…Csontos et al 19 reported that in patients with sepsis due to burn injuries, serum IL-10 levels in patients who died were higher than serum levels of surviving patients. Lorenta et al 20 showed that serum IL-10 levels are higher in patients who died from sepsis in comparison to surviving patients but they also stated that serum TNF-α levels were lower.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Cesur¹

2011

JMID

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Objectives: The purpose of this trial was to investigate in patients with sepsis, the correlation between prognosis of disease and factors, which influence prognosis like gender, focus of infection, bacterial growth in blood culture, growing pathogens in addition to serum levels of cytokines (TNF-α, IL-10, leptin) and C-reactive protein. Material and methods:Forty-six adult patients with sepsis and 55 healthy adults as control group were enrolled in this study. Serum cytokine (TNF-α, IL-10 and leptin) levels were determined by ELISA method and C-reactive protein (CRP) levels were measured by nephelometric method. Serum cytokine and CRP levels on day 0 (initial), day 3 and day 5 were compared in surviving sepsis patients and patients who died because of sepsis.Results: Serum IL-10 level on day 0 (initial) of adult patients who died as a result of sepsis was found to be higher than surviving patients and the difference was statistically significant (p=0.025). On 3 rd day of treatment, serum TNF-α and CRP levels of patients who dies because of sepsis were higher than values of surviving patients (for TNF-α p=0.033, for CRP p=0.026). In adult patient group with sepsis who died on the 5 th day of treatment, serum TNF-α level was significantly higher than levels in surviving patients (p=0.030). Conclusion:It was determined that in patients who died due to sepsis, initial serum IL-10 level, TNF-α and CRP levels on 3 rd day of treatment and finally on 5 th day of treatment, only serum TNF-α level was higher than surviving patients. We believe that determining serum TNF-α and IL-10 levels in patients with sepsis before and during treatment will help clinicians to clarify prognosis and enable them to implement appropriate treatment modifications. Gereç ve yöntem:Çalışmaya 46 erişkin sepsisli hasta ile kontrol grubu olarak ise 55 sağlıklı erişkin dahil edildi. Serum sitokin (TNF-α, IL-10 ve leptin) düzeyleri ELISA yöntemiyle, C-reaktif protein (CRP) düzeyleri ise nefelometrik yöntemle saptandı.Serum sitokin ve CRP düzeyi sepsili ölen hasta grubu ile yaşayanlar arasında başlangıç (0.gün), 3. ve 5.günlerde istatistiksel olarak karşılaştırıldı.Bulgular: Sepsisten ölen erişkin hastalarda başlangıç (0. gün) serum IL-10 düzeyi, yaşayan hastalarinkinden istatistiksel olarak daha yüksek saptandı (p=0.025). Sepsisten ölen hastalarda, tedavinin 3. gününde serum TNF-α ve CRP düzeyleri yaşayan hastalardan daha yüksekti (TNF-α için p değeri=0.033, CRP için p=0.026). Sepsili erişkin hasta grubunda tedavinin 5. gününde ölen hastalarda serum TNF-α düzeyi yaşayan hastalardan daha yüksekti (p=0.03) Sonuç: Sepsisli erişkin hastalrda tedavi başlangıcında serum IL-10 düzeyinin, tedavinin 3. gününde TNF-α ve CRP dü-zeyinin, tedavininin 5. gününde ise sadece serum TNF-α düzeyinin prognostik olduğu belirlendi. Sepsisli hastalarda serum TNF-α ve IL-10 düzeylerinin tedavinin başlangıcında ve tedavi esnasında saptanması hastaların prognozunun belirlenmesinde ve uygun tedavi değişikliklerinin yapılmasında klinisyene yol gösterici olabilir.An...

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Time course of pro- and anti-inflammatory cytokine levels in patients with burns—Prognostic value of interleukin-10

Cited by 52 publications

References 31 publications

Early Modification in Drainage of Interleukin-1β and Tumor Necrosis Factor-α Best Predicts Surgical-Site Infection After Cervical Neck Dissection for Oral Cancer

Early Modification in Drainage of Interleukin-1β and Tumor Necrosis Factor-α Best Predicts Surgical-Site Infection After Cervical Neck Dissection for Oral Cancer

An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-induced Systemic inflammatory Responses by inhibiting interferon Regulatory Factor 5 Pathway

Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

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