1997
DOI: 10.1177/019262339702500607
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Time Course of Stomach Mineralization, Plasma, and Urinary Changes After a Single Intravenous Administration of Gadolinium(III) Chloride in the Male Rat

Abstract: In a previous experiment it was reported that the intravenous administration of gadolinium chloride (GdCl,)

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Cited by 15 publications
(10 citation statements)
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“…Other studies have shown that Gd can cause rapid increases in plasma Ca, as well as causing stomach mineralization and basophilia (20,21). The pathogenesis of Gd-induced tissue calcification is unknown, but hypotheses include metastatic calcification secondary to raised serum Ca and phosphate.…”
Section: Discussionmentioning
confidence: 99%
“…Other studies have shown that Gd can cause rapid increases in plasma Ca, as well as causing stomach mineralization and basophilia (20,21). The pathogenesis of Gd-induced tissue calcification is unknown, but hypotheses include metastatic calcification secondary to raised serum Ca and phosphate.…”
Section: Discussionmentioning
confidence: 99%
“…It also causes lymphocytolysis. Furthermore, administration of GdCl 3 induces a rapid hypercalcemia and hyperphosphatemia, as well as mineralization of the fundic glandular mucosa in the absence of necrosis, followed by mucous cell hyperplasia (89,102,103). Hepatic alterations such as an increase in the number of non-perfused sinusoids accompanied by a reduction in bile flow have also been shown to occur (96).…”
Section: Animal Studiesmentioning
confidence: 99%
“…Another example was reported in rats following intravenous administration of gadolinium chloride. 349 Gadolinium compounds are widely used as contrast agents in magnetic resonance imaging. Treated animals developed a discrete band of interstitial mineralization in the fundic glandular mucosa composed of calcium and phosphate in the form of hydroxyapatite with little or no gadolinium present, findings consistent with a form of metastatic mineralization.…”
Section: Mineralizationmentioning
confidence: 99%
“…Treated animals developed a discrete band of interstitial mineralization in the fundic glandular mucosa composed of calcium and phosphate in the form of hydroxyapatite with little or no gadolinium present, findings consistent with a form of metastatic mineralization. 349…”
Section: Mineralizationmentioning
confidence: 99%