Time course of swept-source optical coherence tomography angiography findings after photodynamic therapy and aflibercept in eyes with age-related macular degeneration

Abstract

Purpose To report swept-source optical coherence tomography angiography (SS-OCTA) findings after full-fluence photodynamic therapy (PDT) and aflibercept intravitreal injection (IVA) for age-related macular degeneration (AMD). Methods Five eyes of five patients with AMD treated with PDT and IVA were include into the study. We retrospectively reviewed the data obtained from the five patients using SS-OCTA before and after treatment. Three eyes had type 1 choroidal neovascularization (CNV) and two eyes had polypoidal choroidal vasculopathy. Results Before treatment, the CNV signals detected in all cases, decreased in three eyes and were not detected completely in two eyes at 1 months after treatment. The areas indicating CNV increased over time, but they did not increase to the baseline level. No CNV signal was detected in one eye during follow-up. In all cases, the exudation unchanged or resolved without additional IVA; the exudation recurred in two cases. In one eye, the CNV signal and the exudation occurred simultaneously; however, there was no association in another eye. A feeder vessel, from which the CNV signal seemed to originate, was seen in one of the five eyes. Conclusion and Importance SS-OCTA is useful to monitor the morphology of CNV after PDT and IVA, indicating that the remodeling of the choroidal vasculature occurs gradually after treatment. The presence or absence of the CNV signal might indicate CNV activity.

A proof of concept study to evaluate the treatment response of aflibercept in wARMD using OCT-A (Canada study)

“…Previous OCT-A studies evaluating response of aflibercept in age-related macular degeneration have primarily been short-term [16][17][18][19][20], included B 5 patients [21] or been retrospective [22][23][24][25][26] in nature. In this long-term, prospective study, we used OCT-A to monitor and evaluate the response of CNVMs after treatment with IAI in 17 patients.…”

Characteristics of Preferred Retinal Locus in Eyes with Central Vision Loss Secondary to Different Macular Lesions

“…Central vision loss (CVL) secondary to maculopathies causes remarkable disturbance to quotidian visual tasks for the lowvision population. [1][2][3][4][5] Two decades ago, the majority of patients with bilateral maculopathy would ultimately suffer catastrophic vision loss until intravitreal anti-neovascularization drugs [6][7][8] and verteporfin with photodynamic therapy 9,10 were applied clinically, preventing the natural progression of the diseases. However, the reversal of CVL has not yet been achieved.…”