Time-course of the antihypertensive and autonomic effects of regular endurance exercise in human subjects

Meredith, Ian T.; Jennings, Garry; Esler, Murray; Dewar, Elizabeth; Bruce, Anne; Fazio, Virginia; Korner, Paul I.

doi:10.1097/00004872-199009000-00010

Cited by 106 publications

(75 citation statements)

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“…If confirmed, this relationship seems similar to that between exercise and blood pressure, the latter being activated vigorously during single episodes of exercise yet is suppressed in the longer term in response to regular moderate exercise. 25,26 Certainly, this scenario appears likely in cardiac failure where aerobic training decreases both circulating norepinephrine and NT-proBNP levels. 27 Any such associations are potentially important for UAE nationals since, as in our report, earlier studies suggest that physical activity levels are particularly low in this population 28,29 and may be linked to high levels of obesity and hypertension.…”

Section: Discussionmentioning

confidence: 99%

Plasma N terminal pro-brain natriuretic peptide levels and its determinants in a multi-ethnic population

et al. 2007

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This study documents the determinants and plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) among hypertensive and normotensive subjects in a multi-ethnic population in the United Arab Emirates (UAE). We obtained demographic, anthropometric and clinical data, together with fasting NT-proBNP and biochemical indices from 128 hypertensive patients and 138 normotensive subjects matched for age, gender and ethnicity. Plasma NT-proBNP levels were significantly (Po0.001), and several-fold higher among hypertensives (median 5.92, inter quartile range (IQR): 1.79-18.48 pmol/l) than normotensives (median 1.78, IQR: 0.59-4.32 pmol/l) in the total study population, and the same was true for the ethnic groups separately. Similarly, plasma levels of glucose, blood urea nitrogen (BUN) and creatinine, but not insulin, were significantly (Po0.05) higher among hypertensives than normotensives. For all subjects combined, log NT-proBNP correlated positively and significantly with age (Po0.01), log glucose (Po0.05), systolic blood pressure (SBP, Po0.001), log BUN (Po0.001) and log creatinine (Po0.001). Multivariate regression analysis showed that NT-proBNP levels were independently and positively correlated with SBP, age, gender, log BUN, Emirati and South East Asian ethnic groups and inversely associated with current exercise. In conclusion, we found circulating levels of NT-proBNP to be significantly increased in hypertensive versus normotensive subjects in the UAE and independently related to SBP, age, gender, indices of renal function and possibly exercise. Our results further suggest a possible modulating effect of ethnicity on NT-proBNP levels.

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Section: Discussionmentioning

confidence: 99%

Plasma N terminal pro-brain natriuretic peptide levels and its determinants in a multi-ethnic population

et al. 2007

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“…Third, in the only other study that has noted early reduction in BP with training, this was observed to occur considerably in advance of any change in plasma catecholamine levels. 8 It is not clear how chronic exercise increases systemic endothelial dilator capacity. One possibility is that repeated shear stress associated with the increased BP of exercise sloughs off ageing endothelial cells and so increases endothelial turnover, resulting in a greater proportion of young cells with higher capacity to produce dilator autocoids.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Second, it is uncertain how long training should continue to confer maximal benefits. Isolated reports have noted reduction in resting BP 3,8 and pressor responses to stressors 9 within matters of weeks, but most studies have involved training of the order of several months or more. Third, it is not known how long any circulatory benefits persist once training terminates.…”

Section: Introductionmentioning

confidence: 99%

Rapid onset and offset of circulatory adaptations to exercise training in men

2006

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Chronic aerobic exercise lowers blood pressure (BP), peripheral resistance and cardiac work, and is used widely in antihypertensive and cardiac rehabilitation programmes. In this study, we tested the hypothesis that the cardiovascular benefits of training would occur progressively over several weeks and would diminish over a similar time course on termination of training. In all, 17 young, healthy men undertook a 4-week programme of cycle ergometry (30 min at 60% VO 2peak 3-4 times/week) and 13 subjects matched for age, body mass index and fitness acted as controls. Resting BP and rate-pressure product (RPP) had fallen significantly after only 1 week's training and reached a nadir after 2 weeks training. At this time, BP had fallen from 12177/ 6676 to 11075/5777 mmHg and resting RPP had fallen from 85710 to 7179 (mmHg (beats min À1 )) À2 (Po0.001 each). In parallel, resting forearm conductance had risen from 0.02670.010 to 0.05270.029 (ml min À1 ) 100 ml À1 mmHg À1 and peak reactive hyperaemia following 3 min brachial artery occlusion was increased from 0.10570.031 to 0.20970.041 (ml min À1 ) 100 ml À1 mmHg À1 (Po0.001 each). No significant further circulatory changes occurred over weeks 3-4 of training. On cessation of training, all values returned to pretraining levels within between 1 (SBP, RPP, vascular conductance) and 2 (DBP, MAP, heart rate, reactive hyperaemia) weeks. The results indicate that the optimal cardiovascular benefits of moderate exercise occur rapidly. At least with short training programmes, the benefits regress once training stops just as quickly as they appeared.

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“…O efeito do treinamento físico na redução parcial da PA de indivíduos hipertensos, reduzindo a morbi mortalidade, é conhecido há quase duas décadas (MEREDITH et al, 1990, ARAKAWA, 1993, LIMA et al, 1993, PAFFENBARGER et al, 1993, GAVA et al, 1995, ZANCHETTI et al, 1995, FORJAZ et al, 1996, VERAS-SILVA et al, 1997, MOTOYAMA et al, 1998, GRASSI e MANCIA, 1998, AMARAL et al, 2000, 2001, KOKKINOS et al, 2001, CHOBANIAN et al, 2003, MELO et al, 2003, WALLACE, 2003TSAI et al, 2004;HORTA et al, 2005, HIGA-TANIGUCHI et al, 2007, FELIX & MICHELINI, 2007. Logo após uma sessão de exercício físico a PA cai, permanecendo abaixo dos níveis encontrados em repouso.…”

Section: Eficácia Do Treinamento Físico E Parâmetros Hemodinâmicosunclassified

“…Uma característica marcante do treinamento físico é a indução da bradicardia de repouso em animais de experimentação, sendo esta indicativa de sua eficácia e observada tanto em normo como em hipertensos (CLAUSEN, 1977, SCHEUER & TIPTON, 1977, MEREDITH et al, 1990, FORJAZ et al, 1996, VERAS-SILVA et al, 1997, AMARAL et al, 2000, 2001, MELO et al, 2003, MARTINS et al, 2005, HIGA-TANIGUCHI et al, 2007, FELIX & MICHELINI, 2007 NEGRÃO & BARRETO, 2006). Embora o aumento da FC seja um dos eventos mais precoces, observado logo após o início da atividade física, quando este é realizado de forma crônica, uma bradicardia de repouso é instalada, como relatado previamente.…”

Section: Eficácia Do Treinamento Físico E Parâmetros Hemodinâmicosunclassified

Efeito do exercício fisico aeróbio sobre os componentes fibroelástico e colágeno da aorta de ratos normotensos e hipertensos, sedentários e treinados.

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Time-course of the antihypertensive and autonomic effects of regular endurance exercise in human subjects

Cited by 106 publications

References 0 publications

Plasma N terminal pro-brain natriuretic peptide levels and its determinants in a multi-ethnic population

Plasma N terminal pro-brain natriuretic peptide levels and its determinants in a multi-ethnic population

Rapid onset and offset of circulatory adaptations to exercise training in men

Efeito do exercício fisico aeróbio sobre os componentes fibroelástico e colágeno da aorta de ratos normotensos e hipertensos, sedentários e treinados.

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