Time course of tissue remodelling and electrophysiology in the rat sciatic nerve after spiral cuff electrode implantation

Thil, Marie-Anne; Duy, Dai Tran; Colin, Idesbald; Delbeke, Jean

doi:10.1016/j.jneuroim.2007.01.021

Cited by 32 publications

(31 citation statements)

References 48 publications

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“…However, as our experiments count a small group of animals (N = 21), subtle changes over time cannot fully be excluded. Nevertheless, our results indicate that once the LCAMP could be recorded, the vagus nerve remained excitable, despite the development of a fibrous capsule around the electrode-nerve interface (Grill and Mortimer, 2000;Thil et al, 2006).…”

Section: Characteristics Of the Lcampmentioning

confidence: 73%

Repeated assessment of larynx compound muscle action potentials using a self-sizing cuff electrode around the vagus nerve in experimental rats

Tahry

Mollet

Raedt

et al. 2011

Journal of Neuroscience Methods

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Section: Characteristics Of the Lcampmentioning

confidence: 73%

Repeated assessment of larynx compound muscle action potentials using a self-sizing cuff electrode around the vagus nerve in experimental rats

Tahry

Mollet

Raedt

et al. 2011

Journal of Neuroscience Methods

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“…Data presented here show that IA EPSP enlargement after nerve crush can be uncoupled from synaptic activity (reversing enlargement was achieved in ways that did not rely on manipulating impulse-evoked transmission). Also, recent evidence shows that implantation of nerve cuffs, part of the procedure used to block AP propagation by tetrodotoxin infusion, induces local inflammatory responses and cytokine expression (Vince et al, 2005;Thil et al, 2007) that may trigger synaptic changes (see below). Thus, the potential generation of molecular signals from axons damaged by nerve cuffs confounds assigning synaptic activity as the primary trigger for IA EPSP enlargement.…”

Section: "Disuse" Hypothesis Revisitedmentioning

confidence: 99%

Enhanced Transmission at a Spinal Synapse TriggeredIn Vivoby an Injury Signal Independent of Altered Synaptic Activity

Bichler¹,

Nakanishi²,

Wang³

et al. 2007

J. Neurosci.

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Peripheral nerve crush initiates a robust increase in transmission strength at spinal synapses made by axotomized group IA primary sensory neurons. To study the injury signal that initiates synaptic enhancement in vivo, we designed experiments to manipulate the enlargement of EPSPs produced in spinal motoneurons (MNs) by IA afferents 3 d after nerve crush in anesthetized adult rats. If nerve crush initiates IA EPSP enlargement as proposed by reducing impulse-evoked transmission in crushed IA afferents, then restoring synaptic activity should eliminate enlargement. Daily electrical stimulation of the nerve proximal to the crush site did, in fact, eliminate enlargement but was, surprisingly, just as effective when the action potentials evoked in crushed afferents were prevented from propagating into the spinal cord. Consistent with its independence from altered synaptic activity, we found that IA EPSP enlargement was also eliminated by colchicine blockade of axon transport in the crushed nerve. Together with the observation that colchicine treatment of intact nerves had no short-term effect on IA EPSPs, we conclude that enhancement of IA-MN transmission is initiated by some yet to be identified positive injury signal generated independent of altered synaptic activity. The results establish a new set of criteria that constrain candidate signaling molecules in vivo to ones that develop quickly at the peripheral injury site, move centrally by axon transport, and initiate enhanced transmission at the central synapses of crushed primary sensory afferents through a mechanism that can be modulated by action potential activity restricted to the axons of crushed afferents.

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“…However, placement of electrodes in direct contact with neural tissue increases the risk that the electrode will lead to deleterious changes in the nerve, such as hypervascularity, edema, axonal degeneration, demyelination, and fibrosis [24,25]. Moreover, several studies have demonstrated that both the inflammatory response and morphological changes at the implantation site significantly affect the performance of implanted electrodes [26].…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation reaches its maximum 1 week after surgery but can it last several weeks [26][27][28]. This sequence of events and its electrophysiological consequences are not well understood; however, the impairment of electrode performance is well documented [26].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic implantation of neural electrodes on pelvic nerves: an experimental study on the obturator nerve in a chronic minipig model

et al. 2011

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show abstract

Time course of tissue remodelling and electrophysiology in the rat sciatic nerve after spiral cuff electrode implantation

Cited by 32 publications

References 48 publications

Repeated assessment of larynx compound muscle action potentials using a self-sizing cuff electrode around the vagus nerve in experimental rats

Repeated assessment of larynx compound muscle action potentials using a self-sizing cuff electrode around the vagus nerve in experimental rats

Enhanced Transmission at a Spinal Synapse TriggeredIn Vivoby an Injury Signal Independent of Altered Synaptic Activity

Laparoscopic implantation of neural electrodes on pelvic nerves: an experimental study on the obturator nerve in a chronic minipig model

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