High‐quality acoustic noise measurements were obtained by two hydrophones located 3 m and 40 m from an active hydrothermal vent on Axial Seamount, Juan de Fuca Ridge, in an effort to determine the feasibility of monitoring hydrothermal vent activity through flow noise generation. Most of the measured noise field could be attributed to ambient ocean noise sources of microseisms, distant shipping, and weather, punctuated by local ships and biological sources. Long‐period, low‐velocity, water/rock interface waves were detected with high amplitudes which rapidly decayed with distance from the seafloor. Detection of vent signals was hampered by unexpected spatial nonstationarity due to the shadowing effects of the caldera wall. No continuous vent signals were deemed significant based on a criterion of 90% probability of detection and 5% probability of false alarm. However, a small signal near 40 Hz, with a power level of 10−4Pa2/Hz was noticed on two records taken within 3 m of the Inferno black smoker. Hie frequency of this signal is consistent with predictions, and the power level suggests the occurrence of jet noise amplification due to convected density inhomogeneities.