Time-dependent analysis of nociception and anxiety-like behavior in rats submitted to persistent inflammation of the temporomandibular joint

Nascimento, Glauce Crivelaro do; Leite–Panissi, Christie Ramos Andrade

doi:10.1016/j.physbeh.2013.11.009

Cited by 45 publications

(39 citation statements)

References 56 publications

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“…A recent study suggests that nerve injury induced persistent pain does not significantly alter “quality of life” in mice using a battery of tests including tests for anxiety behaviors [55]. However, several other studies have demonstrated that rats with persistent nociception also exhibit anxiety-like behavior [13; 22; 27; 49]. The data from this study also indicates that CCI rats with persistent nociception exhibited anxiety-like behaviors.…”

Section: Discussionmentioning

confidence: 51%

Persistent nociception induces anxiety-like behavior in rodents: Role of endogenous neuropeptide S

Zhang

You

et al. 2014

Pain

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Anxiety disorder is a comorbid condition of chronic pain. Analgesics and anxiolytics, subject to addiction and abuse, are currently used to manage pain and anxiety symptoms. However, the cellular mechanism underlying chronic pain and anxiety interaction remains to be elucidated. We report that persistent nociception following peripheral nerve injury induced anxiety-like behavior in rodents. Brain expression and release of neuropeptide S (NPS), a proposed endogenous anxiolytic peptide, was diminished in rodents with co-existing nociceptive and anxiety-like behaviors. Intracerebroventricular administration of exogenous NPS concurrently improved both nociceptive and anxiety-like behaviors. At the cellular level, NPS enhanced intra-amygdaloidal inhibitory transmission by increasing presynaptic GABA release from interneurons. These findings indicate that the interaction between nociceptive and anxiety-like behaviors in rodents may be regulated by the altered NPS-mediated intra-amygdaloidal GABAergic inhibition. The data suggest that enhancing the brain NPS function may be a new strategy to manage comorbid pain and anxiety.

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Section: Discussionmentioning

confidence: 51%

Persistent nociception induces anxiety-like behavior in rodents: Role of endogenous neuropeptide S

Zhang

You

et al. 2014

Pain

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“…Orofacial pain is a painful condition, that is, associated with head and neck tissues as well as oral structures . Temporomandibular disorders (TMD) are an important type of orofacial pain, which may be accompanied by inflammation .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Temporomandibular joint inflammatory models, as the Freund's Adjuvant (CFA) model, promote releasing of inflammatory mediators that produce long‐lasting inflammation and acute and persistent pain in rats. Previous study has shown that, in rats, CFA administration into the TMJ induces an increase in the calcitonin gene‐related peptide (CGRP), nerve growth factor (NGF), interleukin‐1β (IL‐1β) and tumour necrosis factor‐α (TNF‐α) levels, until 6 weeks after administration . Inflammation in the TMJ region results in increased excitability of the trigeminal subnucleus caudalis, which is a sensory nucleus with a laminated structure similar to the spinal dorsal horn and, due to this close similarity has been termed the medullary dorsal horn …”

Section: Introductionmentioning

confidence: 99%

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Transcranial direct‐current stimulation reduces nociceptive behaviour in an orofacial pain model

Scarabelot

Oliveira

Medeiros

et al. 2018

J of Oral Rehabilitation

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Background: Transcranial direct-current stimulation (tDCS) is a noninvasive method of brain stimulation suggested as a therapeutic tool for pain and is related to the reversal of maladaptive plasticity associated with chronic pain.Objectives: This study investigated the effect of tDCS, a non-pharmacological therapy, on local mechanical hyperalgesia, and remote thermal hyperalgesia in rats submitted to orofacial inflammatory pain model, by facial von Frey and hot plate tests, respectively. In addition, we evaluated levels of BDNF, NGF, IL-10 and IL-6 in the brainstem and blood serum of these animals at 24 hours and 7 days after the end of tDCS treatment. Methods:Rats were subjected to temporomandibular joint pain and treated with tDCS. The animals were divided into control, pain and pain + treatment groups.Mechanical and thermal hyperalgesia were evaluated at baseline, 7 days after administration of complete Freund's adjuvant, and immediately, 24 hours, and 7 days after the tDCS treatment. Neuroimmunomodulators levels were determined by ELISA.Statistical analyses were performed by (GEE)/Bonferroni (behavioural tests), threeway ANOVA/SNK (neurochemical tests) and Kruskal-Wallis (histological analysis).Results: Transcranial direct-current stimulation reduced mechanical and thermal hyperalgesia (P < 0.01). We observed interaction between factors (pain and treatment) increasing brainstem BDNF (P < 0.01) and NGF (P < 0.05) levels. Furthermore, we found an increase in IL-6 and IL-10 levels in the brainstem at 24 hours and 7 days after tDCS, respectively. Conclusion:We showed that tDCS reduces thermal and mechanical hyperalgesia induced by orofacial pain until 7 days after treatment. These findings demonstrate that tDCS was effective in the control of orofacial inflammatory pain. K E Y W O R D S hyperalgesia, neuromodulation, orofacial inflammatory pain, tDCS, temporomandibular joint | 41 SCARABELOT ET AL. How to cite this article: Scarabelot VL, de Oliveira C, Medeiros LF, et al. Transcranial direct-current stimulation reduces nociceptive behaviour in an orofacial pain model.

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“…TMD etiologies have multifactorial origin, including physiological, behavioral, and environmental factors (Cairns, ). TMD is involved in stress‐related disorders that are characterized by somatic and psychological alterations, such as anxiety and depression (Bush et al , ; Korszun et al , ; Nascimento and Leite‐Panissi, ). The complex characteristics of TMDs and the intense pain reported by patients have led to the emergence of many non‐surgical strategies to treat these disorders, including the use of medications such as analgesics and anti‐inflammatories, physical therapy, occlusal adjustment, acupuncture, and low‐level laser therapy (LLLT) (Petrucci et al , ).…”

Section: Introductionmentioning

confidence: 99%

Laser therapy reduces gelatinolytic activity in the rat trigeminal ganglion during temporomandibular joint inflammation

et al. 2015

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Time-dependent analysis of nociception and anxiety-like behavior in rats submitted to persistent inflammation of the temporomandibular joint

Cited by 45 publications

References 56 publications

Persistent nociception induces anxiety-like behavior in rodents: Role of endogenous neuropeptide S

Persistent nociception induces anxiety-like behavior in rodents: Role of endogenous neuropeptide S

Transcranial direct‐current stimulation reduces nociceptive behaviour in an orofacial pain model

Laser therapy reduces gelatinolytic activity in the rat trigeminal ganglion during temporomandibular joint inflammation

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