Time dependent changes of striatal interneurons after focal cerebral ischemia in rats

Sakuma, Mio; Hyakawa, N.; Kato, Harubumi; Araki, Tsutomu

doi:10.1007/s00702-007-0860-z

Cited by 34 publications

(36 citation statements)

References 43 publications

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“…The pyramidal neurons of the hippocampus are essential for cognitive functions such as spatial learning and memory, and are selectively destroyed after cerebral ischemia (Morris et al 1982). The neuronal injury associated with ischemia is accompanied by changing the cholinergic system (Hou et al 2008;Sakuma et al 2008). One-hundred days after ischemia, depletion of CA1 pyramidal cells and marked shrinkage of the CA1 subfield were noted and high density bands of AChE activity in the stratum pyramidale of the CA1 were found to be broadened (Onodera et al 1990).…”

Section: Discussionmentioning

confidence: 97%

Correlations Between Cholinesterase Activity and Cognitive Scores in Post-Ischemic Rats and Patients with Vascular Dementia

Xiao

Guan

et al. 2011

Cell Mol Neurobiol

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The biochemical changes such as the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were investigated in rats with global cerebral ischemia and in vascular dementia (VaD) subjects in this study. The AChE activity showed a significant decrease in plasma and a significant increase in the hippocampus but not in the cerebral cortices in the post-ischemic rats as compared to the controls. The learning abilities and spatial memory were impaired in the post-ischemic rats as compared to controls. Furthermore, the AChE activity in plasma was significantly reduced in VaD subjects as compared to normal control subjects. The BuChE activity did not show any change in both post-ischemic rats and VaD patients. Interestingly, the decreased AChE activity in plasma from the post-ischemic rats and the VaD subjects showed a significant correlation with the declined learning and memory ability, and the Mini-Mental State Examination score, respectively. These data suggest that the AChE activity is involved in the cognitive recovery after ischemia, and the plasma level of AChE might be a reliable supplementary peripheral biomarker to evaluate the cognitive recovery degree of VaD patients.

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Section: Discussionmentioning

confidence: 97%

Correlations Between Cholinesterase Activity and Cognitive Scores in Post-Ischemic Rats and Patients with Vascular Dementia

Xiao

Guan

et al. 2011

Cell Mol Neurobiol

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“…We previously demonstrated that PV-positive interneurons in hippocampal CA1 sector were vulnerable to transient cerebral ischemia in gerbils compared with nNOS-positive interneurons (Himeda et al 2005). Our recent study also showed that the severe damage of PVpositive interneurons was more pronounced than that of nNOS-positive interneurons in the striatum after transient focal cerebral ischemia in rats (Sakuma et al 2008). Based on these observations, we suggest that PV-positive interneurons in the substantia nigra during postnatal development may undergo maturation in a delayed manner, when compared with nNOS-positive interneurons in this region.…”

Section: Discussionmentioning

confidence: 89%

Postnatal Development of Neurons, Interneurons and Glial Cells in the Substantia Nigra of Mice

et al. 2010

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We investigated postnatal alterations of neurons, interneurons and glial cells in the mouse substantia nigra using immunohistochemistry. Tyrosine hydroxylase (TH), neuronal nuclei (NeuN), parvalbumin (PV), neuronal nitric oxide synthase (nNOS), glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor molecule 1 (Iba 1), CNPase (2',3'-cyclic nucleotide 3'-phosphodiesterase), brain-derived neurotrophic factor (BDNF) and glial cell-line-derived neurotrophic factor (GDNF) immunoreactivity were measured in 1-, 2-, 4- and 8-week-old mice. In the present study, the maturation of NeuN-immunopositive neurons preceded the production of TH in the substantia nigra during postnatal development in mice. Furthermore, the maturation of nNOS-immunopositive interneurons preceded the maturation of PV-immunopositive interneurons in the substantia nigra during postnatal development. Among astrocytes, microglia and oligodendrocytes, in contrast, the development process of oligodendrocytes is delayed in the substantia nigra. Our double-labeled immunohistochemical study suggests that the neurotrophic factors such as BDNF and GDNF secreted by GFAP-positive astrocytes may play some role in maturation of neurons, interneurons and glial cells of the substantia nigra during postnatal development in mice. Thus, our findings provide valuable information on the development processes of the substantia nigra.

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“…There are many reports that striatal interneurons, depending on neuronal types, showed selective vulnerability after transient and focal ischemic insults (Yamada et al 1995;Larsson et al 2001;Katchanov et al 2003;Sakuma et al 2008). It has also been reported that hippocampal interneurons including PV ?…”

Section: Discussionmentioning

confidence: 96%

Calcium Binding Proteins Immunoreactivity in the Rat Basolateral Amygdala Following Myocardial Infarction

et al. 2009

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In this study, we examined changes in immunoreactivities of calcium binding proteins, such as parvalbumin (PV), calbindin (CB), and calretinin (CR), in the rat basolateral amygdala (BLA) 14 days after myocardial infarction (MI). In the MI-operated group, numbers of PV and CB immunoreactive ((+)) neurons in the BLA were significantly reduced compared to those in the sham-operated group. However, numbers of CR(+) neurons were slightly, not significantly, reduced in the MI-operated group. These results indicate that MI may decrease the immunoreactivities of PV and CB, not CR, in the rat BLA.

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Time dependent changes of striatal interneurons after focal cerebral ischemia in rats

Cited by 34 publications

References 43 publications

Correlations Between Cholinesterase Activity and Cognitive Scores in Post-Ischemic Rats and Patients with Vascular Dementia

Correlations Between Cholinesterase Activity and Cognitive Scores in Post-Ischemic Rats and Patients with Vascular Dementia

Postnatal Development of Neurons, Interneurons and Glial Cells in the Substantia Nigra of Mice

Calcium Binding Proteins Immunoreactivity in the Rat Basolateral Amygdala Following Myocardial Infarction

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