Time dependent cisplatin dosing differences on hypoalgesia focusing on oxidative stress

Update on chronotherapy: it's about time

“…Malignant cells can show abnormal circadian rhythms that may contribute to cancer development 6 . Dr Dallmann adds that the toxicity of various cancer chemotherapeutics varies during the day depending on enzyme activity ( eg capecitabine) or kidney perfusion ( eg cisplatin) 2,3 . Oxaliplatin, for example, is best tolerated when delivery peaks at 16:00 hours 4 .…”

“…6 Dr Dallmann adds that the toxicity of various cancer chemotherapeutics varies during the day depending on enzyme activity (eg capecitabine) or kidney perfusion (eg cisplatin). 2,3 Oxaliplatin, for example, is best tolerated when delivery peaks at 16:00 hours. 4 When used in ovarian cancer, administering doxorubicin at 06:00 and cisplatin between 16:00-20:00 reduced complications and toxicity with both drugs and increased tumour response and five-year survival.…”

“…Insulin glargine is more effective when given in the morning 1 . In cancer patients, chronotherapy improves the efficacy and reduces the toxicity of capecitabine (a prodrug of 5‐fluorouracil), oxaliplatin, doxorubicin plus cisplatin, and, probably, immune checkpoint inhibitors and cancer vaccines 2‐6 . The protective immune response against certain pathogens, such as hepatitis A virus and SARS‐CoV‐2, may depend on the time of day when the vaccine is administered 7 …”

“…1 In cancer patients, chronotherapy improves the efficacy and reduces the toxicity of capecitabine (a prodrug of 5-fluorouracil), oxaliplatin, doxorubicin plus cisplatin, and, probably, immune checkpoint inhibitors and cancer vaccines. [2][3][4][5][6] The protective immune response against certain pathogens, such as hepatitis A virus and SARS-CoV-2, may depend on the time of day when the vaccine is administered. 7 "Using retard formulations [which have a constant release rate] for cardiovascular disease is 'chronotherapy' in disguise," says Dr Robert Dallmann, A s s o c i a t e P r o f e s s o r o f C a n c e r Biomedicine and Chronotherapy, Warwick Medical School.…”