Time-dependent depressive symptoms and risk of cardiovascular and all-cause mortality among the Chinese elderly: The Beijing Longitudinal Study of Aging

Li, Haibin; Halm‐Lutterodt, Nicholas Van; Zheng, Deqiang; Liu, Yue; Guo, Jin; Feng, Wei; Li, Xia; Wang, Anxin; Liu, Xiangtong; Tao, Lixin; Hou, Chengbei; Luo, Yanxia; Zhang, Feng; Yang, Xinghua; Gao, Qi; Wang, Wei; Tang, Zhe; Guo, Xiuhua

doi:10.1016/j.jjcc.2018.02.015

Cited by 19 publications

(26 citation statements)

References 49 publications

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“…The Reasons for Geographical and Racial Differences in Stroke Study 36 also found that severe depressive symptoms were associated with an increased risk of coronary heart disease, stroke, and mortality. A recent cohort study 22 suggested that time-dependent depressive symptoms were associated with 1.4-fold risk of cardiovascular mortality. In addition, several meta-analyses and systematic reviews 12,13,21 found a positive association between severe depressive symptoms and increased risk of CVD.…”

Section: Discussionmentioning

confidence: 99%

Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Zheng

et al. 2019

JAMA Netw Open

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Key PointsQuestionAre depressive symptoms associated with incident cardiovascular disease among middle-aged and older Chinese adults?FindingsIn this cohort study of 12 417 Chinese adults, participants with depressive symptoms at baseline had higher incident rates of cardiovascular disease compared with those without such symptoms. Elevated depressive symptoms as a whole and 2 individual symptoms (restless sleep and loneliness) were significantly associated with increased risk of cardiovascular disease after adjusting for potential confounders.MeaningThis study suggests that depressive symptoms, particularly restless sleep and loneliness, may be associated with incident cardiovascular disease among middle-aged and older Chinese adults.

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Section: Discussionmentioning

confidence: 99%

Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Zheng

et al. 2019

JAMA Netw Open

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159

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“…We found 4 studies [7][8][9][10] in adults in China, including 3 studies in adults 65 years and older and 1 study in adults 55 years and older. Three studies 7,9,10 found that the association of depressive symptoms with all-cause mortality was stronger among men than women. However, studies in younger adults in China are lacking, and 1 meta-analysis 11 found that depression was also associated with excess mortality in women, although not as much as in men.…”

Section: Introductionmentioning

confidence: 99%

“…In a 2013 cohort study of 62 839 participants in Hong Kong 65 years or older, Sun et al33 reported that depressive symptoms, defined as a score of 8 or higher on the 15-item Geriatric Depression Scale, were associated with higher CHD mortality risk in men but not in women. In a cohort study among 1999 participants in Beijing, China, Li et al10…”

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confidence: 99%

Association of Depression With All-Cause and Cardiovascular Disease Mortality Among Adults in China

et al. 2020

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“…To select a representative sample whose geographic distribution, economic status, age and education were similar to those of the Beijing population older than 55 years, a three-stage stratification-random clustering sampling method was conducted during cohort establishment. A full description of the design and implementation of this cohort study has been described previously 25 26. Briefly, 3257 community residents who were from the Xuanwu District (urban), Daxing County (suburb, rural) and Huairou County (extended suburb, mountain), aged at least 55 years were invited to participate in 1992.…”

Section: Methodsmentioning

confidence: 99%

Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of type 2 diabetes mellitus among Chinese elderly: the Beijing Longitudinal Study of Aging

Zheng

et al. 2020

BMJ Open Diab Res Care

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Objective Time-dependent covariates are generally available as longitudinal data were collected periodically in the cohort study. To examine whether time-dependent triglyceride to high-density lipoprotein cholesterol (TG/ HDL-C) ratio could predict the future risk of type 2 diabetes mellitus (T2DM) and assess its potential impact on the risk of T2DM incidence.Research design and methods This study enrolled 1460 participants without T2DM aged 55 or above in 1992 in the Beijing Longitudinal Study of Aging during 25 years. The questionnaire data were collected in nine surveys from 1992 to 2017. Physical examination and blood laboratory tests including TG and HDL-C concentrations were measured in five surveys. Incident T2DM cases were confirmed via a self-reported history of T2DM or the fasting plasma glucose level.Results 119 new cases of T2DM were identified. In the Cox regression analysis with time-dependent TG/HDL-C ratios and covariates, the adjusted hazard ratios (95% confidence interval) of T2DM incidence were 1.90 (1.12 to 3.23), 2.75 (1.58 to 4.80) and 2.84 (1.69 to 4.77), respectively, for those with TG/HDL-C ratios (both TG and HDL-C were expressed in millimole per liter) in the ranges of 0.87-1.30, 1.31-1.74 and ≥1.75, compared with individuals with TG/HDL-C ratios <0.87. The similar results of subdistribution hazard ratios were obtained by performing the Fine-Gray model with time-dependent TG/ HDL-C ratios. This positive association and the statistically significant trend with increased risk of T2DM incidence in the three categories of elevated TG/HDL-C ratio was confirmed by multiple sensitivity analyses. Furthermore, the T2DM discriminatory power of TG/HDL-C ratio combining with other risk factors was moderately high. Conclusions We found that time-dependent TG/HDL-C ratios were positively associated with the risk of T2DM risk. The elevated TG/HDL-C ratios increased the future risk of T2DM incidence. Lowering the TG/HDL-C ratio could assist in the prevention of diabetes for older adults. ► Lowering TG/HDL-C ratio could assist to prevent T2DM in the general population, and monitoring lipid profile deserves more attention in clinical practice. on July 5, 2020 by guest. Protected by copyright.

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Time-dependent depressive symptoms and risk of cardiovascular and all-cause mortality among the Chinese elderly: The Beijing Longitudinal Study of Aging

Abstract: Time-dependent depressive symptoms increased the risk of all-cause and cardiovascular mortality among the elderly in China.

Cited by 19 publications

References 49 publications

Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Association of Depression With All-Cause and Cardiovascular Disease Mortality Among Adults in China

Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of type 2 diabetes mellitus among Chinese elderly: the Beijing Longitudinal Study of Aging

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