Time-dependent effects of isolation on lymphocyte and adrenocortical activity

Jessop, John J.; Bayer, Barbara

doi:10.1016/0165-5728(89)90033-7

Cited by 32 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Decades ago, individual housing was shown to impact the health and behaviors of laboratory rats (Wiberg and Grice, 1963;Korn and Moyer, 1968). Since then, it has been shown to affect a wide range of physiological variables such as blood pressure and heart rate (Woodworth and Johnson, 1988), circadian rhythms (Greco et al, 1989), sexual maturation (Swanson and van de Poll, 1983), body weight and life span (Menich and Baron, 1984;Moon et al, 2006), drug responsiveness (Juraska et al, 1983), and immune system activity (Jessop and Bayer, 1989). It also affects behavioral measures such as spontaneous pup retrieval (Herrenkohl and Lisk, 1973), sexual activity (Spevak et al, 1973;Swanson and van de Poll, 1983), morphine self-administration (Alexander et al, 1978), and open-field activity (Dalrymple-Alford and Benton, 1981;Menich and Baron, 1984;Thorsell et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Social isolation prevents exercise‐induced proliferation of hippocampal progenitor cells in female rats

2009

View full text Add to dashboard Cite

Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social isolation retards exercise-induced neurogenesis in the hippocampal dentate gyrus (DG) of male rats (Stranahan et al. (2006) Nat Neurosci 9:526-533). Since male and female rats react differently to housing changes and exercise opportunities, we investigated whether social isolation would also suppress the exercise-dependent increase in proliferation of dentate gyrus progenitor cells in females. Accordingly, female rats were housed either alone (isolated) or in groups (social) with (exercise) or without (sedentary) the opportunity to run in an exercise wheel. Proliferating progenitor cells were labeled with bromodeoxyuridine (BrdU). As expected, exercise increased the number of BrdU+ cells in socially housed animals. However, isolation prevented this running-induced increase. Our results expand upon previous findings by showing that the female brain is also susceptible to the suppressive effect of social isolation on exercise-induced neurogenesis.

show abstract

Section: Introductionmentioning

confidence: 99%

Social isolation prevents exercise‐induced proliferation of hippocampal progenitor cells in female rats

2009

View full text Add to dashboard Cite

show abstract

“…In addition to studies reporting stress-induced reductions on immunity [5][6][7], recent lines of evidence indicate that, under several cir cumstances, stress can lead to an enhancement of certain immune responses [8][9][10] and also that acute stres-induced immunosuppression may return to normal values [11][12][13] or even result in immunoenhancement [2,14,15] with repeated exposure to stress. Additionally, evidence also exists of stressful situations involving activation of neuroendocrine activity which is not accompanied by alterations in the immune response [16].…”

mentioning

confidence: 99%

Mutually Antagonistic Effects of Corticosterone and Prolactin on Rat Lymphocyte Proliferation

Sandi

Cambronero²,

Borrell³

et al. 1992

Neuroendocrinology

View full text Add to dashboard Cite

The present study was designed to evaluate the immunological outcome resulting from experimental conditions involving different corticosterone and prolactin ratios in rats. One set of experiments was conducted to assess the effects of prolactin and corticosterone on the in vitro mitogen-induced proliferation of spleen lymphocytes from animals previously submitted to the manipulation of their glucocorticoid status throughout adrenalectomy (ADX) and/or exposure to acute stress. The results indicated that prolactin (5 × 10^–9 M) induced a significant increase in concanavalin A- (ConA) induced proliferation of splenocytes only from ADX-control, unstressed, rats. However, a lower dose of prolactin (10^–9M) failed to influence lymphoproliferation. Corticosterone (2 × 10^–8 and 10^–7M) induced a dose-dependent reduction in lymphocyte proliferation in all experimental groups. Further experiments were conducted to study the relative potency of prolactin to antagonize the in vitro corticosterone-induced suppression of ConA-stimulated lymphocytes. The results showed, on the one hand, that higher doses of prolactin (10^–8 and 5 × 10^–8M) were effective in stimulating ConA-induced lymphocyte proliferation in control, undisturbed, rats. They also showed that when prolactin and corticosterone are simultaneously added to the cultures, the immunostimulatory effect induced by a dose of 10^–8M of prolactin can either predominate over a weak suppressive action of corticosterone (2 × 10^–8M) or totally antagonize to normal values a marked immunosuppression induced by a higher dose of corticosterone (10^–7M). These data support the view that different ratios between prolactin and corticosterone concentrations can result in differential immunological outcome. They also suggest that under conditions involving high levels of prolactin, the immunostimulatory properties of prolactin on T cell function may predominate over the immunosuppressive effects of corticosterone.

show abstract

“…Activation of the hypothalamic-pituitary-adrenal (HPA) axis is directly and indirectly interacting with the intake of alcohol and other psychotropic agents [26,27]. Social isolation activates the HPA axis only for a short time (some days), but in the long run rather leads to a reduced level of corticosterone [28]. In contrast, changing cage mates lead to sustained activation of HPA axis (fi ghts and threatening among the cage mates, loss of body weight) [29] .…”

mentioning

confidence: 99%

Loss of Flexibility in Alcohol-Taking Rats: Promoting Factors

Turyabahika-Thyen¹,

Wolffgramm²

2006

Eur Addict Res

View full text Add to dashboard Cite

Alcohol consumption in humans can move from a flexible pattern of intake to an inflexible (addictive) one. Several endogenous and exogenous factors are discussed to be involved in this transition. The purpose of this study was to examine factors that might promote the development of inflexibility. Over a period of 52 weeks (long-term) rats had continuously free choice between differently concentrated alcohol solutions and tap water (four-bottle paradigm). After 4 months of alcohol deprivation, a retest with free choice of alcohol was performed. Bitter-taste conditions were used to test the flexibility of alcohol taking. In the retest alcohol-experienced rats revealed a much higher alcohol intake than previously alcohol-naive ones. Part of the alcohol-experienced animals showed impairment of flexibility in alcohol taking. During long-term choice, some groups were submitted to experimental interventions that might affect addiction development (stress, withdrawal, limited access, adverse consequences). Rats with limited access to alcohol at the end of the long-term choice period took more alcohol and were less flexible in the retest than any other group. It is suggested that an unsatisfied urge for alcohol leads to impairment of control over alcohol drinking.

show abstract

Time-dependent effects of isolation on lymphocyte and adrenocortical activity

Cited by 32 publications

References 10 publications

Social isolation prevents exercise‐induced proliferation of hippocampal progenitor cells in female rats

Social isolation prevents exercise‐induced proliferation of hippocampal progenitor cells in female rats

Mutually Antagonistic Effects of Corticosterone and Prolactin on Rat Lymphocyte Proliferation

Loss of Flexibility in Alcohol-Taking Rats: Promoting Factors

Contact Info

Product

Resources

About