Time-dependent retention deficits induced by post-training injections of atropine into the caudate nucleus

Prado-Alcalá, Roberto A.; Signoret, L.; Figueroa, M.

doi:10.1016/0091-3057(81)90221-5

Cited by 29 publications

(3 citation statements)

References 15 publications

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“…Of these neuronal elements, indirect evidence suggests that the memory improvement produced by the D2 agonist LY 171555 may result from an interaction with the cholinergic system. The DA receptor regulating the dopaminergic effect on acetylcholine (ACh) activity is of the D2 subtype (Euvard, Permont, Oberlander, Bossier, & Bockaert, 1979; Hertting, Zumstein, Jackish, Hoffmann, & Starke, 1980; Sethy, 1979; Stoof & Kebabian, 1982), and several studies have shown that posttraining manipulation of cholinergic function by nonselective ACh agonists and antagonists in the caudate nucleus can effect memory (Neill & Grossman, 1970; Prado-Alcala & Cobos-Zapian, 1977, 1979; Prado-Alcala, Signoret, & Figueroa, 1981).…”

Section: Discussionmentioning

confidence: 99%

Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists.

Packard¹,

White²

1991

Behavioral Neuroscience

356

192

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The effect of posttraining intracerebral injections of the indirect dopamine (DA) agonist d-amphetamine, the direct D2 agonist LY 171555, and the direct D1 agonist SKF-38393 on the acquisition of two 8-arm radial maze tasks were examined. On a win-stay task, a light cue signaled the location of food in 4 randomly selected maze arms on each trial, and animals were required to visit each of the lit arms twice within a trial. Posttraining intracaudate injection of d-amphetamine (10.0 and 15.0 micrograms), LY 171555 (2.0 micrograms), and SKF-38393 (5.0 micrograms) all improved win-stay acquisition in relation to saline-injected controls. In contrast, posttraining intrahippocampal injection of DA agonists had no effect on win-stay acquisition. On a win-shift task, rats were allowed to obtain food from 4 randomly selected maze arms, followed by a delay period in which they were removed from the maze. They were returned to the maze for a retention test in which only those arms that had not been visited before the delay contained food. Posttraining intrahippocampal (but not intracaudate) injection of d-amphetamine (5.0 micrograms), LY 171555 (2.0 micrograms), and SKF-38393 (5.0 micrograms) all improved win-shift retention in relation to saline-injected controls. The results demonstrate a double dissociation of hippocampus and caudate nucleus memory functions and show that posttraining injection of both D1 and D2 agonists modulate the memory processes subserved by both hippocampus and caudate nucleus.

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Section: Discussionmentioning

confidence: 99%

Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists.

Packard¹,

White²

1991

Behavioral Neuroscience

356

192

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“…Early studies from the mid-sixties to the late seventies used pretraining, irreversible lesion procedures to selectively destroy striatal nuclei and reveal their importance in avoidance learning, see for instance [161] and [180]. In the following years, Prado-Alcala and colleagues addressed the role of the striatal cholinergic system in the learning tasks [72,160,162,163,192]. Interestingly, blockade of muscarinic receptors with either scopolamine or atropine produced amnesia at 24 hours in passive avoidance, but not at 30 min, and only when administered within minutes after training, suggesting that cholinergic interneurons in the dorsal striatum may be necessary to stabilize the initial trace before consolidation.…”

Section: Rodent Models For Learning and Memorymentioning

confidence: 98%

Cellular Mechanisms of Striatum-Dependent Behavioral Plasticity and Drug Addiction

Fasano

Brambilla

2002

CMM

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The striatum has long been known to be involved in the control of motor behavior, since disruption of dopamine-mediated function in this brain structure is directly linked to Parkinson's disease and other disorders of movement. However, it is now accepted that both dorsal and ventral striatal nuclei are also essential for a variety of cognitive processes, which depend on reward-based stimulus-response learning. Since the neuroanatomical and neurochemical organization of dorsal and ventral striatum is only partially overlapping, it is likely that both common and nucleus-specific cellular and molecular events contribute to synaptic plasticity, learning and memory processes mediated by these cerebral structures. Alterations in cell signaling in the striatum may be particularly important in the response to both acute and chronic administration of drugs of abuse, resulting in maladaptive changes in the reward-based associative learning involved in addiction, withdrawal and relapse.

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“…To be effective, the posttraining injection has to be conducted very quickly after training. Injections 2 or 3.75 min after training are effective, but a delay of 7.5 min renders the atropine ineffective (Prado-Alcala et al, 1981). Interestingly, the avoidance deficit is seen only if the retention test is delayed for 24 hr.…”

Section: Caudate Nucleus and Amygdala Injectionsmentioning

confidence: 98%

Handbook of Psychopharmacology

Iversen¹,

Iversen²,

Snyder³

1988

608

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Time-dependent retention deficits induced by post-training injections of atropine into the caudate nucleus

Cited by 29 publications

References 15 publications

Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists.

Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists.

Cellular Mechanisms of Striatum-Dependent Behavioral Plasticity and Drug Addiction

Handbook of Psychopharmacology

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