Time‐dependent, spontaneous release of white cell‐ and platelet‐derived bioactive substances from stored human blood

Nielsen, Hans Jørgen; Reimert, Claus M.; Pedersen, Anders N.; Brünner, Nils; Edvardsen, L; Dybkjær, E.; Kehlet, Henrik; Skov, Per Stahl

doi:10.1046/j.1537-2995.1996.36111297091738.x

Cited by 152 publications

(143 citation statements)

References 39 publications

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“…Potential causes of delayed morbidity include acute lung injury, 6,7 infection, [8][9][10] and multiple organ failure 10,11 mediated by pro-inflammatory effects of leukocytes. 29 We found several other noteworthy associations. First, later year of hospital admission was associated with higher 48-hr mortality.…”

Section: Discussionmentioning

confidence: 58%

Early massive transfusion in trauma patients: Canadian single-centre retrospective cohort study

Mahambrey

Fowler

Pinto

et al. 2009

Can J Anesth/J Can Anesth

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Purpose To determine associations between red blood cell (RBC) transfusion and early and late clinical outcomes in massively transfused adult trauma patients. Methods A retrospective cohort study (1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001) including 260 patients receiving C10 RBC units B24 hr after admission to a university-affiliated trauma centre. We extracted demographic and clinical data and used multivariable regression to determine independent effects of RBC transfusion on clinical outcomes. ]).Conclusions Hospital mortality is high among massively transfused trauma patients. Among early survivors, 48-hr RBC transfusion volume is associated with increased organ dysfunction, but not hospital mortality. Also, it is not associated with 48-hr mortality. Future research should continue to explore methods to improve hemostasis and minimize the need for RBC transfusion. RésuméObjectif De´terminer les associations qui existent entre la transfusion d'e´rythrocytes et les devenirs cliniques R. A. Fowler and N. K. J. Adhikari contributed equally to this study.

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Section: Discussionmentioning

confidence: 58%

Early massive transfusion in trauma patients: Canadian single-centre retrospective cohort study

Mahambrey

Fowler

Pinto

et al. 2009

Can J Anesth/J Can Anesth

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“…These mediators are contained in intracellular WBC granules, and are released in a time-dependent manner as the WBCs deteriorate during storage [59]. It has been shown that at least some of these biologic response modifiers (histamine, eosinophil cationic protein, eosinophil protein X, TGF-β) may contribute to the development of immunosuppression and tissue damage by inhibition of neutrophils, cytotoxic T-cells and natural killer cells [60], [61], [62], [63].…”

Section: Immunosuppressionmentioning

confidence: 99%

Transfusion-transmissible infections and transfusion-related immunomodulation

Buddeberg

Schimmer

Spahn

2008

Best Practice & Research Clinical Anaesthesiology

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Transfusion-transmissible infections and transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years. However, after human immunodeficiency virus and hepatitis B and C virus transmission were successfully reduced, new pathogens are threatening the safety of the blood supply, especially in the face of rising numbers of immunocompromised transfusion recipients. Despite new standards in the manufacture and storage of blood products, bacterial contamination still remains a considerable cause of transfusion-related morbidity and mortality. Better allograft survival in kidney transplant patients and higher cancer recurrence rate in surgical oncology patients after allogeneic blood transfusions highlighted a previously underestimated side-effect: transfusion-related immunomodulation (TRIM). The precise pathomechanism still remains uncertain; however, its mostly deleterious effects--such as a higher incidence of postoperative or nosocomial infections--is increasingly accepted. Although transfusion-related immunomodulation is thought to be mediated mainly by donor white blood cells, the benefit of leukoreduction on overall mortality and on infectious complications is highly debatable. Transfusion-transmissible infections and Transfusion-related immunomodulation Transfusion-transmissible infections and Transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years.

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“…The average WBC content of transfused WBCreduced RBCs was less than 5 ϫ 10 6 per unit, and was often as low as 1 ϫ 10 6 per unit. The timing of the filtration procedure is important because biologic response modifiers released from WBC granules in a time-dependent manner during storage may mediate the adverse TRIM effects, 39,48,[56][57][58][59][60] and-if such TRIM effects really exist-only WBC-reduced RBCs filtered before storage can be expected to abrogate the adverse effects. Two RCTs administered autologous RBCs 4 or whole blood 23 to the control arm.…”

Section: Design Of Clinical Studiesmentioning

confidence: 99%

Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?

Vamvakas

Blajchman

2001

Blood

389

272

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Time‐dependent, spontaneous release of white cell‐ and platelet‐derived bioactive substances from stored human blood

Cited by 152 publications

References 39 publications

Early massive transfusion in trauma patients: Canadian single-centre retrospective cohort study

Early massive transfusion in trauma patients: Canadian single-centre retrospective cohort study

Transfusion-transmissible infections and transfusion-related immunomodulation

Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?

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