Time‐dependent variation of HLA‐antigen‐frequencies in fflV‐1‐infection (1983–1988)

Kuntz, B. M. E.; Brüster, H

doi:10.1111/j.1399-0039.1989.tb01732.x

Cited by 7 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epidemiological studies seem to support this assumption, because some reports have provided evidence for an association between MHC alleles or haplotypes and disease progression (35,66). More precisely, the haplotype A1-B8-DR3 and the alleles HLA-DR2 and HLA-DR5 have been associated with an accelerated progression to AIDS (19,33,34,40). Another example is the relation between the HLA-DR1 allele and Kaposi's sarcoma or the correlation between HLA-DR3 and the apparition of opportunistic infections (39).…”

Section: Fig 5 Kinetics Of Virus Infection When Virions Bearing or mentioning

confidence: 99%

The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity

Cantin

Fortin

Lamontagne

et al. 1997

J Virol

128

View full text Add to dashboard Cite

Human immunodeficiency virus type 1 (HIV-1) incorporates several host cell components when budding out of the infected cell. One of the most abundant host-derived molecules acquired by HIV-1 is the HLA-DR determinant of the major histocompatibility complex class II (MHC-II) molecules. The fact that CD4 is the natural ligand of MHC-II prompted us to determine if such virally embedded cellular components can affect the biology of the virus. Herein, we report for the first time that the incorporation of cellular HLA-DR1 within HIV-1 enhances its infectivity. This observation was made possible with virions bearing or not bearing on their surfaces host-derived HLA-DR1 glycoproteins. Such virus stocks were prepared by a transient-expression system based on transfection of 293T cells with a recombinant luciferase-encoding HIV-1 molecular clone along with plasmids encoding the ␣ and ␤ chains of HLA-DR1. Cell-free virions recovered from transfected cells were shown to have efficiently incorporated host-derived HLA-DR1 glycoproteins. Infectivity was increased by a factor of 1.6 to 2.3 for virions bearing on their surfaces host-derived HLA-DR1. The observed enhancement of HIV-1 infectivity was independent of the virus stocks used and was seen in several T-lymphoid cell lines, in a premonocytoid cell line, and in primary peripheral blood mononuclear cells. Finally, we determined that the presence of virion-bound cellular HLA-DR1 is associated with faster kinetics of virus infection. Taken together, these results suggest that HLA-DR-1-bearing HIV-1 particles had a greater infectivity per picogram of viral p24 protein than HLA-DR1-free virions.

show abstract

Section: Fig 5 Kinetics Of Virus Infection When Virions Bearing or mentioning

confidence: 99%

The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity

Cantin

Fortin

Lamontagne

et al. 1997

J Virol

128

View full text Add to dashboard Cite

show abstract

“…Ofinterest is that when the A l , B8 alleles are split from DR3 (not a common occurrence) the susceptibility to increased rate of progression goes with A l , B8 and not DR3 (Mann et d, 1994). Other Class I alleles associated with rapid disease progression include HLA B35 and A24 (Cameron et al, 1990 (Jeannet et al 1989: Enlow et aI, 1983Depaoli et al 1986: Kuntz & Bruster, 1989. Mann et a1 (1994) have noted a marked influence of DR1 on the rate of progression to disease that exerts its effects early after seroconversion.…”

Section: Lminunological Features Of Hlv Infectionmentioning

confidence: 99%

Autoimmune Mechanisms of Depletion of Cd4 Cells in Hiv Infection

1995

Br J Haematol

View full text Add to dashboard Cite

“…Resistance to infection in a cohort of repeatedly exposed female sex workers recently was reported to be associated with HLA-DRB1*01 [1]. Other HLA class II alleles have been associated with rapid HIV disease progression [2][3][4][5]. HLA class I genes also have been reported to exert a protective effect (reviewed in Westby et al [6]).…”

mentioning

confidence: 95%

Generation of Alloantigen‐Stimulated Anti–Human Immunodeficiency Virus Activity Is Associated withHLA‐A*02Expression

Grene¹,

Pinto²,

Cohen

et al. 2001

J INFECT DIS

View full text Add to dashboard Cite

Stimulation of peripheral blood mononuclear cells (PBMC) with allogeneic PBMC (ALLO) can result in activity that inhibits the replication of human immunodeficiency virus (HIV). The present study demonstrates that strong anti-HIV activity is dependent on expression of HLA-A*02 by the responding PBMC. Anti-HIV activity was equally effective against 2 primary isolates that use different coreceptors. Neither ALLO-stimulated cell proliferation nor cytokine and beta-chemokine production was associated with the expression of HLA-A*02. ALLO-stimulated production of strong anti-HIV activity required intact PBMC and was not inhibited by monoclonal antibodies directed against nonpolymorphic regions of human leukocyte antigens (HLAs). Anti-HIV activity was generated by ALLO-stimulated CD4(+) cells, CD8(+) T lymphocytes, and monocytes from HLA-A*02-positive patients. These findings provide the first evidence that the production of an HIV inhibitory factor or factors is associated with certain HLA genes and raise new possibilities concerning the role of the major histocompatibility complex in controlling viral infections via alloantigen stimulation.

show abstract

Time‐dependent variation of HLA‐antigen‐frequencies in fflV‐1‐infection (1983–1988)

Cited by 7 publications

References 24 publications

The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity

The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity

Autoimmune Mechanisms of Depletion of Cd4 Cells in Hiv Infection

Generation of Alloantigen‐Stimulated Anti–Human Immunodeficiency Virus Activity Is Associated withHLA‐A*02Expression

Contact Info

Product

Resources

About