Time Difference of Arrival on Contrast-Enhanced Ultrasound in Distinguishing Benign Inflammation From Malignant Peripheral Pulmonary Lesions

Tang, Min; Xie, Qianrong; Wang, Jiasi; Zhai, Xiaoyu; Hong, Lin; Zheng, Xiaoxue; Wei, Guoli; Tang, Yuchen; Zeng, Fanwei; Chu, Yanpeng; Song, Jianqiong; Cai, Jianqiang; Zeng, Fanxin

doi:10.3389/fonc.2020.578884

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…This significant difference between the two groups was consistent with the findings reported by Zhang et al, [ 29 ] Zhang, [ 10 ] and Tang. [ 30 ] The time required for the contrast agent to reach the lung lesion and adjacent lung tissue is affected by many factors, including heart function, lung disease, contrast agent injection speed, and other individual differences. The use of ∆AT as an observation index for the differential diagnosis of benign and malignant lung lesions can eliminate the influence of these factors and reduce the minor individual differences.…”

Section: Discussionmentioning

confidence: 99%

“…The use of ∆AT as an observation index for the differential diagnosis of benign and malignant lung lesions can eliminate the influence of these factors and reduce the minor individual differences. Some studies [30][31][32] found that real-time comparative observations can be used to reduce the influence of individual differences, and the time difference between lesion and lung tissue enhancement (∆AT) can be used as an observation index for the differential diagnosis of benign and malignant lung lesions. ∆AT<2.5 seconds indicates benign lesions with early enhancement, while ∆AT>2.5 seconds indicates malignant lesions with late enhancement.…”

Section: Discussionmentioning

confidence: 99%

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Application value of contrast-enhanced ultrasound in the diagnosis of peripheral pulmonary focal lesions

Bai¹,

Liu²,

Liu³

et al. 2022

Medicine

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Introduction: Peripheral pulmonary lesions are encountered frequently in clinical practice. Accurate diagnosis of these lesions is of great importance for clinicians. Ultrasound-guided lung tissue puncture is a reliable method for diagnosing these lesions. Objectives: To investigate the application value of contrast-enhanced ultrasound (CEUS) combined with rapid on-site evaluation (ROSE) in the diagnosis of peripheral pulmonary focal lesions. Methods: Eighty patients enrolled from July 2020 to June 2021 were divided into two groups: a conventional ultrasound group and a CEUS group. Both groups underwent diagnostic procedures guided by ROSE to improve the success rate of puncture sampling. The success rates and complications in both groups were compared. The results for lesion enhancement, time taken for the contrast agent to reach the lesions (AT) and lung tissues (L-AT), and the difference between these times (∆AT) were compared in the CEUS group. Results: The success rate of biopsy in the CEUS group was 97.62%, which was significantly higher than that in the conventional ultrasound group (84%; P < .05). Puncture complications did not occur in the CEUS group and occurred in 5.26% of the cases in the conventional ultrasound group, but the difference was not statistically significant (P > .05). A comparison of enhancement of benign lesions and malignant lesions in the CEUS group showed a statistically significant difference (P < .05). The difference between the AT and ∆AT of benign and malignant lesions was statistically significant (P <.05). The optimal threshold of ∆AT was 2.05 s. Conclusion: CEUS combined with ROSE is a very important approach for biopsy in the diagnosis of peripheral pulmonary focal lesions. CEUS has definite clinical value in the diagnosis of benign and malignant lung lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Application value of contrast-enhanced ultrasound in the diagnosis of peripheral pulmonary focal lesions

Bai¹,

Liu²,

Liu³

et al. 2022

Medicine

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“…Contrast-enhanced ultrasound (CEUS) adopts a blood pool contrast agent, which can be detected in microvessels with low flow, thus reducing Doppler artifacts to reflect the blood flow distribution more accurately ( 19 , 20 ). Like the liver, the lung also has a dual arterial blood supply, which may be helpful in the evaluation of peripheral pulmonary lesions ( 21 ). To date, CEUS has been widely used in the biopsy of various organs, including the lung, pancreas, and liver.…”

Section: Introductionmentioning

confidence: 99%

Enhanced ultrasound-guided versus non-enhanced ultrasound-guided percutaneous needle biopsy in tissue cellularity of lung malignancies: a propensity score matched study

Zhou¹,

Zhang²,

Chen³

et al. 2022

Quant Imaging Med Surg

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Background: Though ultrasound-guided percutaneous lung needle biopsy (US-PLNB) is a first-line small biopsy method for peripheral lung lesions, quality of cellularity in specimens obtained via US-PLNB is uncertain. This study investigated the accuracy, sensitivity, and cellularity of US-PLNB. It examined the ability of contrast-enhanced ultrasound (CEUS) to improve the effectiveness of US-PLNB. Methods:We retrospectively analyzed all data of patients with subpleural lung lesions who underwent US-PLNB. The cellularity of US-PLNB from malignant lesions included the tumor cell number and proportion.The definition of high-quality cellularity (HQC) was concurrently achieving a tumor cell number ≥400 and a proportion ≥20%. The sensitivity, the actual numbers of tumor cell number/proportion, and the rate of HQC were calculated and compared between the CEUS and non-enhanced US groups after propensity score matching (PSM) with subgroup analyses by lesion size (small lesion ≤30 mm and large lesion >30 mm).Results: A total of 345 patients undergoing 345 US-PLNBs were evaluated, with 3.7±1.1 of punctures on average. There were 201 malignant and 144 benign lesions with a mean size of 43.8±24.1 mm. Among the 201 malignant lesions, 124 cases underwent CEUS and 77 underwent non-enhanced US. The quantity of tumor cells, the proportion of tumor cells, and the rate of HQC in 201 cases of US-PLNB from malignant lesions were 2,862.1±2,288.0, 44.6%±24.5%, and 82.1% [95% confidence interval (CI): 76.6% to 87.1%],respectively. The quantity of tumor cells, the proportion of tumor cells, and rate of HQC were significantly higher in the CEUS group than that in the non-enhanced US group, both in the analysis of overall malignant lesions and in large malignant lesions (all P<0.05). Conclusions:The US-PLNB has high sensitivity and thereby obtains HQC samples for subpleural lung malignant lesions. The CEUS helps improve the rate of HQC and tissue cellularity of lung malignancies.

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“…The use of contrast-enhanced ultrasound in conjunction with blood cell analysis improved the diagnostic accuracy of plasma cell mastitis (24). Min Tang demonstrated that CEUS has high diagnostic accuracy in distinguishing benign inflammation from the malignant peripheral pulmonary disease (25).…”

Section: Discussionmentioning

confidence: 99%

Differentiation Between Granulomatous Lobular Mastitis and Breast Cancer Using Quantitative Parameters on Contrast-Enhanced Ultrasound

et al. 2022

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ObjectiveTo investigate the Contrast-enhanced ultrasound (CEUS) imaging characteristics of granulomatous lobular mastitis (GLM) and the value of differentiating GLM from breast cancer.Materials and methodsThe study included 30 women with GLM (mean age 36.7 ± 5 years [SD]) and 58 women with breast cancer (mean age 48. ± 8 years [SD]) who were scheduled for ultrasound-guided tissue biopsy. All patients were evaluated with conventional US and CEUS prior to the biopsy. In both groups, the parameters of the quantitative and qualitative analysis of the CEUS were recorded and compared. The receiver-operating-characteristics curves (ROC) were created. Sensitivity, specificity, cut-off, and area under the curve (AUC) values were calculated.ResultsTTP values in GLM were statistically higher than in breast cancer (mean, 27.63 ± 7.29 vs. 20.10 ± 6.11), but WIS values were lower (mean, 0.16 ± 0.05 vs. 0.28 ± 0.17). Rich vascularity was discovered in 54.45% of breast cancer patients, but only 30.00% of GLM patients had rich vascularity. The AUC for the ROC test was 0.791 and 0.807, respectively. The optimal cut-off value for TTP was 24.5s, and the WIS cut-off value was 0.185dB/s, yielding 73.33% sensitivity, 84.48% specificity, and 86.21% sensitivity, 70% specificity respectively in the diagnosis of GLM. The lesion scores reduced from 4 to 3 with the addition of CEUS for the patients with GLM. However, the scores did not change for the patients with breast cancer.ConclusionCEUS could help distinguish GLM from breast cancer by detecting higher TTP and WIS values, potentially influencing clinical decision-making for additional biopsies.

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Time Difference of Arrival on Contrast-Enhanced Ultrasound in Distinguishing Benign Inflammation From Malignant Peripheral Pulmonary Lesions

Cited by 8 publications

References 33 publications

Application value of contrast-enhanced ultrasound in the diagnosis of peripheral pulmonary focal lesions

Application value of contrast-enhanced ultrasound in the diagnosis of peripheral pulmonary focal lesions

Enhanced ultrasound-guided versus non-enhanced ultrasound-guided percutaneous needle biopsy in tissue cellularity of lung malignancies: a propensity score matched study

Differentiation Between Granulomatous Lobular Mastitis and Breast Cancer Using Quantitative Parameters on Contrast-Enhanced Ultrasound

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