Time-domain image processing using dynamic holography

Ding, Y.; Nolte, David D.; Melloch, M. R.; Weiner, Andrew M.

doi:10.1109/2944.686739

Cited by 39 publications

(21 citation statements)

References 42 publications

(69 reference statements)

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“…They have applications in laser-based ultrasound detection, 157,160 optical coherence imaging, [161][162][163][164] and femtosecond pulse manipulation. [165][166][167] A spinning disk carrying patterned protein films through a focused laser beam represents a highfrequency phase modulation that can be captured under phase-locked conditions using adaptive interferometry. 57 As an example of an assay on the adaptive optical BioCD, a two-analyte assay was performed that had two targets, mouse IgG capturing antimouse IgG, and rabbit IgG capturing antirabbit IgG.…”

Section: Adaptive Optical Biocdmentioning

confidence: 99%

Invited Review Article: Review of centrifugal microfluidic and bio-optical disks

Nolte

2009

Review of Scientific Instruments

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Spinning biodisks have advantages that make them attractive for specialized biochip applications. The two main classes of spinning biodisks are microfluidic disks and bio-optical compact disks ͑BioCD͒. Microfluidic biodisks take advantage of noninertial pumping for lab-on-a-chip devices using noninertial valves and switches under centrifugal and Coriolis forces to distribute fluids about the disks. BioCDs use spinning-disk interferometry, under the condition of common-path phase quadrature, to perform interferometric label-free detection of molecular recognition and binding. The optical detection of bound molecules on a disk is facilitated by rapid spinning that enables high-speed repetitive sampling to eliminate 1 / f noise through common-mode rejection of intensity fluctuations and extensive signal averaging. Multiple quadrature classes have been developed, such as microdiffraction, in-line, phase contrast, and holographic adaptive optics. Thin molecular films are detected through the surface dipole density with a surface height sensitivity for the detection of protein spots that is approximately 1 pm. This sensitivity easily resolves a submonolayer of solid-support immobilized antibodies and their antigen targets. Fluorescence and light scattering provide additional optical detection techniques on spinning disks. Immunoassays have been applied to haptoglobin using protein A/G immobilization of antibodies and to prostate specific antigen. Small protein spots enable scalability to many spots per disk for high-throughput and highly multiplexed immonoassays.

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Section: Adaptive Optical Biocdmentioning

confidence: 99%

Invited Review Article: Review of centrifugal microfluidic and bio-optical disks

Nolte

2009

Review of Scientific Instruments

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“…1,2 However, because of the low refractive-index modulations or the small thicknesses of the nonlinear material used for recording these gratings, the Bragg diffraction properties of thick gratings may be insufficient for practical applications. In such a case, as shown theoretically, 3 this inconvenience can be overcome by placing the sinusoidal grating in a FabryPerot cavity.…”

Section: Introductionmentioning

confidence: 99%

Diffraction of Gaussian beams on intracavity Bragg gratings

et al. 2005

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The diffraction of Gaussian beams on intracavity Bragg gratings is analyzed theoretically. For reasonable waists the associated beam divergence does not significantly influence the diffraction efficiency of such devices. Nevertheless, the tilt angle of the incident beam, imposed by the Bragg resonance condition, strongly reduces the diffraction efficiency at short grating periods. However, the angular selectivity can be maintained if the Fabry-Perot cavity is tuned to the incident beam direction, which allows the use of small-volume holograms together with a dense angular multiplex. This theoretical analysis can be applied to the optimization of the diffraction properties of Gaussian beams on any intracavity Bragg grating, which could then be used for freespace parallel signal processing.

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“…Researchers have also employed the concepts of spatial holography to process time-domain information, e.g. for temporal-domain imaging processing [4] or photochemical hole burning [5]. We refer here to 'temporal holography' as the time-domain counterpart of spatial holography.…”

mentioning

confidence: 99%