Very popular research in the field of Modern control Engineering is design of controllers for nonlinear systems. It is obvious that all the real-world systems are multivariable and nonlinear in nature which is highly challenging to control these nonlinear systems as it exhibits complexity. In addition to these, all the real systems exhibit uncertainty due to slow or sudden changes in process parameters. Hence, the design of robust nonlinear controller should have an ability to handle these uncertainties. The design of controllers for nonlinear system needs proper selection of appropriate input–output pairing. This book chapter focus on the conventional and proposed method of control configuration selection for nonlinear systems.