Time-dose factors in radiotherapy: a review of the human data

Thames, Howard D.; Bentzen, Søren M.; Turesson, Ingela; Overgaard, Marie; Bogaert, Walter Van den

doi:10.1016/0167-8140(90)90149-q

Cited by 386 publications

(150 citation statements)

References 63 publications

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“…The values of ␣/␤ for early and late reactions in human normal tissues are consistent with those obtained from animal experiments (26). For human tumors however, ␣/␤ ratios are more variable than in animals.…”

Section: Tissue-repair Capacitysupporting

confidence: 84%

Pulse Frequency in Pulsed Brachytherapy Based on Tissue Repair Kinetics

Sminia

Schneider

Koedooder

et al. 1998

International Journal of Radiation OncologyBiologyPhysics

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Section: Tissue-repair Capacitysupporting

confidence: 84%

Pulse Frequency in Pulsed Brachytherapy Based on Tissue Repair Kinetics

Sminia

Schneider

Koedooder

et al. 1998

International Journal of Radiation OncologyBiologyPhysics

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“…Other reports were consistent with this finding, but an overview failed to detect a significant effect (36)(37)(38). Treatment time has no impact on the risk of late adverse effects, assuming a 24-hour interfraction interval and complete repair (39,40). Current protocols for accelerated hypofractionation to partial breast, using threedimensional (3D) conformal radiotherapy, include twicedaily fractions separated by 6 hours (41).…”

Section: Accelerated Fractionation Might Improve Tumor Control But Rmentioning

confidence: 63%

Hypofractionated Whole-Breast Radiotherapy for Women With Early Breast Cancer: Myths and Realities

Yarnold

Bentzen

Coles

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

148

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“…The value of 0.4 has been determined based on the clinical study by Bjork‐Eriksson et al (16) In addition, it was assumed that the SF2 value for normal tissue is constant

false(SF 2 = 0.4 false)

. The values of α/β ratios for tumor cells and normal cells were considered to be 10 Gy and 2.5 Gy, respectively (17) . The values of the SF2 and α/β ratios for both normal tissue and tumor were used in the linear quadratic model to extract the α and β values (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Is grid therapy useful for all tumors and every grid block design?

Gholami

Nedaie

Longo

et al. 2016

J Applied Clin Med Phys

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Grid therapy is a treatment technique that has been introduced for patients with advanced bulky tumors. The purpose of this study is to investigate the effect of the radiation sensitivity of the tumors and the design of the grid blocks on the clinical response of grid therapy. The Monte Carlo simulation technique is used to determine the dose distribution through a grid block that was used for a Varian 2100C linear accelerator. From the simulated dose profiles, the therapeutic ratio (TR) and the equivalent uniform dose (EUD) for different types of tumors with respect to their radiation sensitivities were calculated. These calculations were performed using the linear quadratic (LQ) and the Hug‐Kellerer (H‐K) models. The results of these calculations have been validated by comparison with the clinical responses of 232 patients from different publications, who were treated with grid therapy. These published results for different tumor types were used to examine the correlation between tumor radiosensitivity and the clinical response of grid therapy. Moreover, the influence of grid design on their clinical responses was investigated by using Monte Carlo simulations of grid blocks with different hole diameters and different center‐to‐center spacing. The results of the theoretical models and clinical data indicated higher clinical responses for the grid therapy on the patients with more radioresistant tumors. The differences between TR values for radioresistant cells and radiosensitive cells at 20 Gy and 10 Gy doses were up to 50% and 30%, respectively. Interestingly, the differences between the TR values with LQ model and H‐K model were less than 4%. Moreover, the results from the Monte Carlo studies showed that grid blocks with a hole diameters of 1.0 cm and 1.25 cm may lead to about 19% higher TR relative to the grids with hole diameters smaller than 1.0 cm or larger than 1.25 cm (with 95% confidence interval). In summary, the results of this study indicate that grid therapy is more effective for tumors with radioresistant characteristics than radiosensitive tumors.PACS number(s): 87.55.‐x

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Time-dose factors in radiotherapy: a review of the human data

Cited by 386 publications

References 63 publications

Pulse Frequency in Pulsed Brachytherapy Based on Tissue Repair Kinetics

Pulse Frequency in Pulsed Brachytherapy Based on Tissue Repair Kinetics

Hypofractionated Whole-Breast Radiotherapy for Women With Early Breast Cancer: Myths and Realities

Is grid therapy useful for all tumors and every grid block design?

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