Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

Mathisen, Gro H.; Bearth, Angela; Jones, Lowenna B.; Hoffmann, Sebastian; Vist, Gunn E.; Ames, Heather M.; Husøy, Trine; Svendsen, Camilla; Tsaioun, Katya; Ashikaga, Takao; Bloch, Denise; Cavoski, Aleksandra; Chiu, Weihsueh A.; Davies, Holly G.; Giusti, Arianna; Hartung, Thomas; Hirabayashi, Yoko; Hogberg, Helena T.; Joglekar, Rashmi; Kojima, Hajime; Krishnan, Kannan; Kwon, Seok; Osborne, Olivia J.; Roggen, Erwin; Rooney, Andrew A.; Rousselle, Christophe; Sass, Jennifer B.; Sepai, Ovnair; Simanainen, Ulla; Thayer, Kristina A.; Tong, Weida; Wikoff, Daniele; Wright, Fred; Whaley, Paul

doi:10.1007/s00204-024-03802-6

Arch Toxicol

2024

DOI: 10.1007/s00204-024-03802-6

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Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

Gro H. Mathisen,

Angela Bearth,

Lowenna B. Jones

et al.

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Cited by 2 publications

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Animal-free safety assessment of chemicals: an innovation system perspective

Hoogstraaten,

Vriend,

de Leeuw

et al. 2024

Arch Toxicol

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This perspective paper, which is the result of a collaborative effort between toxicologists and scholars in innovation and transition studies, presents a heuristic framework based on innovation system literature for understanding and appraising mission achievement to animal-free chemical safety assessment using New Approach Methodologies (NAMs). While scientific and technical challenges in this area are relatively well known, the recent establishment of missions and roadmaps to accelerate the acceptance and effective use of NAMs for chemical safety assessment raises new questions about how we can grasp the systemic nature of all changes needed in this transition. This includes recognising broader societal, institutional, and regulatory shifts necessary for NAM acceptance and uptake. Our paper discusses how the innovation system approach offers insights into key processes and associated activities that include as well as transcend the technical and scientific realm, and can help to accelerate acceptance and uptake of NAMs. Based on these insights, we present a comprehensive framework that, next to scientific and technological developments, recognises the need for coordinated efforts in areas like education, training, funding, policy-making, and public engagement to promote the acceptance and uptake of NAMs. Our framework can be used to perform structural and functional analyses of the innovation system of NAMs and animal-free safety assessment and as such provides handholds to track progress and organise collective efforts of actors to make sure we are moving in the right direction.

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Animal-free safety assessment of chemicals: an innovation system perspective

Hoogstraaten,

Vriend,

de Leeuw

et al. 2024

Arch Toxicol

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CompSafeNano Project: NanoInformatics Approaches for Safe-by-Design Nanomaterials

Zouraris,

Mavrogiorgis,

Tsoumanis

et al. 2024

Computational and Structural Biotechnology Journal

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Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

Cited by 2 publications

References 21 publications

Animal-free safety assessment of chemicals: an innovation system perspective

Animal-free safety assessment of chemicals: an innovation system perspective

CompSafeNano Project: NanoInformatics Approaches for Safe-by-Design Nanomaterials

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