This article deals with fractional systems that represent better physical process and guarantee a very small number of parameters that can reduces the computation time. It focuses in particular on the state-space representation which highlights the state variables and allows to study the internal behavior of the system taking into account the initial state. Moreover, this representation adapts better to the multiple input multiple-output case. It also discusses the discretization of fractional system to finally adapt the Model Predictive Control to apply it and shows its efficiency and performance in these systems. The main objective of this article is to compare the commensurate and noncommensurate fractional models performance, calculation time and ease of use.