Time-gated fluorescence imaging: Advances in technology and biological applications

Yang, Wenzhao; Chen, Sung‐Liang

doi:10.1142/s1793545820300062

Cited by 25 publications

(14 citation statements)

References 86 publications

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“…Their emission properties, easily tunable by simple functionalization of the coordinated ligands, afford a wide range of possibilities ranging from blue to red emitters [12] . Moreover, their excited state lifetimes, much longer to those of endogenous fluorophores (0.1–7 ns) [13] facilitate the use of time‐gated techniques that eliminate autofluorescence of the sample and renders images with greater signal‐to‐noise ratio [14] …”

Section: Introductionmentioning

confidence: 99%

“…[12] Moreover, their excited state lifetimes, much longer to those of endogenous fluorophores (0.1-7 ns) [13] facilitate the use of time-gated techniques that eliminate autofluorescence of the sample and renders images with greater signal-to-noise ratio. [14] Taking into account the advantages displayed by metallic complexes in cellular imaging, and the importance of cellular tracking for the development of novel and more effective metallodrugs, the idea of combining a metallic bioprobe with a luminescent complex to function as tracking tag is very appealing. By this means, the concept of heterometallic theranostic agents arises, and every day is gathering more supporters among the research community.…”

Section: Introductionmentioning

confidence: 99%

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Theranostics Through the Synergistic Cooperation of Heterometallic Complexes

2021

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Heterometallic drugs are emerging as a great alternative to conventional metallodrugs. Careful selection of different metallic fragments makes possible to enhance not only the therapeutic potential by a synergistic effect, but also to incorpore key features like traceability. Drugs that integrate traceability and therapy in one system are known as theranostic agents. In cancer research, theranostic agents are becoming increasingly important. They deliver crucial information regarding their biological interplay that can ultimately be used for optimization. The well‐established therapeutic potential of PtII‐, RuII‐ and AuI‐based drugs combined with the outstanding optical properties of d6 transition metal complexes grant the delivery of traceable metallodrugs. These species can be easily fine‐tuned through modification of their respective ligands to provide a new generation of drugs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Theranostics Through the Synergistic Cooperation of Heterometallic Complexes

2021

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“…This concept can be applied to IR, RAMAN as well as UV-Vis radiation with the requirement that a fluorescent tracer or target material has a long fluorescent lifetime and hence a long decay time [ 64 , 66 , 68 ]. The development of TGFS has been pushed by the technological advancements of light sources, imaging and sensor hardware, and prototypes have demonstrated a relative high sorting quota of differently colored and marked POM but the technique is not yet ready for industrial usage since parameters like line speed, which correlates with the detection time, need to be improved [ 66 , 69 ].…”

Section: Detection Techniques For Sensor-based Sortingmentioning

confidence: 99%

Evaluation of Marker Materials and Spectroscopic Methods for Tracer-Based Sorting of Plastic Wastes

et al. 2022

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Plastics are a ubiquitous material with good mechanical, chemical and thermal properties, and are used in all industrial sectors. Large quantities, widespread use, and insufficient management of plastic wastes lead to low recycling rates. The key challenge in recycling plastic waste is achieving a higher degree of homogeneity between the different polymer material streams. Modern waste sorting plants use automated sensor-based sorting systems capable to sort out commodity plastics, while many engineering plastics, such as polyoxymethylene (POM), will end up in mixed waste streams and are therefore not recycled. A novel approach to increasing recycling rates is tracer-based sorting (TBS), which uses a traceable plastic additive or marker that enables or enhances polymer type identification based on the tracer’s unique fingerprint (e.g., fluorescence). With future TBS applications in mind, we have summarized the literature and assessed TBS techniques and spectroscopic detection methods. Furthermore, a comprehensive list of potential tracer substances suitable for thermoplastics was derived from the literature. We also derived a set of criteria to select the most promising tracer candidates (3 out of 80) based on their material properties, toxicity profiles, and detectability that could be applied to enable the circularity of, for example, POM or other thermoplastics.

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“…Optical molecular imaging technology is an extraordinary tool that can provide noninvasive, high-accuracy and high-resolution optical information in biomedical areas [1][2][3][4]. In order to stimulate the progress of this technology, the most important point is to promote innovations of higher-performance molecular probes [5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Deep NIR-I Emissive Iridium(III) Complex Bearing D-A Ligand: Synthesis, Photophysical Properties and DFT/TDDFT Calculation

Jiang

et al. 2021

Crystals

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Near-infrared (NIR) phosphorescent iridium(III) complexes have been demonstrated to possess photophysical properties superior to those of traditional NIR dyes. However, the NIR emission wavelength is restricted in the range of 700–800 nm. For realizing deeper NIR emission, a novel type of iridium(III) complex was designed and synthesized in this work. The main ligand of the iridium(III) complex was constructed using a donor-acceptor structure containing benzothiophene as the donor and quinoxaline as the acceptor. The β-diketone derivative was chosen as the auxiliary ligand owing to its symmetrical structure and p-donating character. The complex exhibits deep NIR-I phosphorescence (764 nm in CH2Cl2, 811 nm in aqueous solution) and broad full width at half maximum (108 nm in CH2Cl2, 154 nm in aqueous solution). Theoretical calculations based on the density function and time-dependent density function were carried out to support the experimental data. Moreover, in vitro biological performance of the complex was determined as well. This work supports the possibility that via a systematic transformation between the D and A units, the photophysical performance of NIR emissive iridium(III) complexes can be greatly improved.

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Time-gated fluorescence imaging: Advances in technology and biological applications

Cited by 25 publications

References 86 publications

Theranostics Through the Synergistic Cooperation of Heterometallic Complexes

Theranostics Through the Synergistic Cooperation of Heterometallic Complexes

Evaluation of Marker Materials and Spectroscopic Methods for Tracer-Based Sorting of Plastic Wastes

Deep NIR-I Emissive Iridium(III) Complex Bearing D-A Ligand: Synthesis, Photophysical Properties and DFT/TDDFT Calculation

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