Time‐gated luminescence imaging of positively charged <scp>poly‐</scp><scp>l‐</scp>lysine‐coated highly microporous silicon nanoparticles in living <i>Hydra</i> polyp

Schiattarella, Chiara; Moretta, Rosalba; Defforge, Thomas; Gautier, Gaël; Ventura, Bartolomeo Della; Terracciano, Monica; Tortiglione, Claudia; Fardella, Federica; Maddalena, Pasqualino; Stefano, Luca De; Velotta, R.; Rea, Ilaria

doi:10.1002/jbio.202000272

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…The pSi film supported by polymer (E) is commonly prepared from the polymer and the pSi film, which is crushed and separated from the bulk Si using the electropolishing method [38,39]. Lastly, polymer composite pSiNPs (F) are much more challenging formulations than the encapsulated ones because each particle needs to be compressed into a polymer layer [1,2,[40][41][42][43][44].…”

Section: Hybrid System Of Psinps and Polymersmentioning

confidence: 99%

Recent advances in hybrid system of porous silicon nanoparticles and biocompatible polymers for biomedical applications

Jung

Kim

2021

Biomed. Eng. Lett.

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Hybrid systems of nanoparticles and polymers have emerged as a new material in the biomedical field. To date, various kinds of hybrid systems have been introduced and applied to drug delivery, regenerative medicine, therapeutics, disease diagnosis, and medical implantation. Among them, the hybridization of nanostructured porous silicon nanoparticles (pSiNPs) and biocompatible polymers has been highlighted due to its unique biological and physicochemical properties. This review focuses on the recent advances in the hybrid systems of pSiNPs and biocompatible polymers from an engineering aspect and its biomedical applications. Representative hybrid formulations, (i) Polymer-coated pSiNPs, (ii) pSiNPs-embedded polymeric nanofibers, are outlined along with their preparation methods, biomedical applications, and future perspectives. We believe this review provides insight into a new hybrid system of pSiNPs and biocompatible polymers as a promising nano-platform for further biomedical applications.

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Section: Hybrid System Of Psinps and Polymersmentioning

confidence: 99%

Recent advances in hybrid system of porous silicon nanoparticles and biocompatible polymers for biomedical applications

Jung

Kim

2021

Biomed. Eng. Lett.

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“…Among various probes with long-lived luminescence for time-gated (or time-resolved) biosensing/imaging [ 13 , 14 ], manganese- (Mn-) doped nanocrystals (NCs) including I(II)-III-VI NCs are attractive in biomedical research (i.e., biosensing/imaging) [ 15 , 16 ]. Mn-doped I(II)-III-VI NCs can be synthesized in a relatively low temperature and a short time (<200°C, 1–2 h, an energy-saving procedure) and have low toxicity synthesis/handling/disposal.…”

Section: Introductionmentioning

confidence: 99%

A Highly Sensitive Time-Gated Fluorescence Immunoassay Platform Using Mn-Doped AgZnInS/ZnS Nanocrystals as Signal Transducers

et al. 2021

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In this work, a time-gated immunoassay platform using low-energy excitable and fluorescence long-lived Mn:AgZnInS/ZnS nanocrystals as signal transducers was developed and applied to the detection of the capsular polysaccharide (CPS) of Burkholderia pseudomallei, a Gram-negative bacterium that is the causative agent of melioidosis. CPS is a high molecular weight antigen displayed and is shed from the outer membrane of B. pseudomallei. The immunoassay using the time-gated platform presents a limit of detection at around 23 pg/ml when CPS is spiked in human serum.

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Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics

et al. 2022

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The number of in vitro, ex vivo, and in vivo studies on porous silicon (PSi) nanoparticles for biomedical applications has increased extensively over the last decade. The focus of the reports has been on the carrier properties of PSi concerning the therapeutic aspect due to several beneficial nanovector characteristics including high payload capacity, biocompatibility, and versatile surface chemistry. Recently, increasing attention has been paid to the diagnostic aspects of PSi, which is typically attributed to the biotraceability of the nanovector. Also, PSi has been studied as a contrast agent. When both these aspects, therapy and diagnosis, are integrated into one nanovector, we can discuss a real nanotheranostics approach. Herein, we review the recent progress developing PSi for various imaging modalities, specifically focusing on optical imaging, magnetic resonance imaging, and nuclear medicine imaging. Furthermore, we summarized the knowledge gaps that must be covered before applying PSi in clinical imaging, highlighting future research trends.

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Time‐gated luminescence imaging of positively charged poly‐l‐lysine‐coated highly microporous silicon nanoparticles in living Hydra polyp

Cited by 9 publications

References 40 publications

Recent advances in hybrid system of porous silicon nanoparticles and biocompatible polymers for biomedical applications

Recent advances in hybrid system of porous silicon nanoparticles and biocompatible polymers for biomedical applications

A Highly Sensitive Time-Gated Fluorescence Immunoassay Platform Using Mn-Doped AgZnInS/ZnS Nanocrystals as Signal Transducers

Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics

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