Time interval from castration in premenopausal women to development of excessive coronary atherosclerosis

Parrish, Henry M.; Carr, C A; Hall, David G.; King, Theodore M.

doi:10.1016/0002-9378(67)90314-6

Cited by 145 publications

(25 citation statements)

References 11 publications

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“…These sections were projected, and the area occupied by intima and intimal lesion was measured with a Zeiss Mop III Image Analyzer (digitizer). The extent of coronary artery atherosclerosis for each animal was expressed as the median intimal (plaque) area (in mm 2 ) of the 15 sections of coronary artery.…”

Section: Necropsy and The Measurement Of Atherosclerosismentioning

confidence: 99%

“…At the carotid bifurcation, one standard cross section was taken for microscopic evaluation; in taking this section, bifurcation pads ("intimal cushions") were avoided. Lesion area and thickness were measured (in mm 2 and mm, respectively) with the digitizer. Five serial sections were taken from each common carotid and iliaco-femoral artery and median intimal area (in mm 2 ) was determined for each by using the digitizer.…”

Section: Necropsy and The Measurement Of Atherosclerosismentioning

confidence: 99%

See 1 more Smart Citation

Ovariectomy, social status, and atherosclerosis in cynomolgus monkeys.

Adams¹,

Kaplan²,

Clarkson³

et al. 1985

Arteriosclerosis

151

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Evidence is contradictory regarding the effects of natural or surgical menopause on "female protection" against coronary artery atherosclerosis. We evaluated atherosclerosis, plasma lipids, blood pressure, and carbohydrate tolerance in 21 ovariectomized and 23 intact female cynomolgus macaques fed a moderately atherogenic diet for 30 months. We also evaluated the influence of social dominance status, with particular emphasis on a possible relationship with ovarian endocrine function. Atherosclerosis was two to 10 times as extensive in coronary, carotid, and iliacofemoral arteries of the ovariectomized females; this could be explained, in part, by 15% to 20% increases in total plasma and LDL cholesterol concentrations. Socially dominant intact females were protected against advanced atherosclerotic lesions (plaques) of the coronary arteries, while subordinate females and ovariectomized females were not. Increased susceptibility to advanced coronary artery atherosclerosis in subordinate intact females may have been related in some way to chronic ovarian dysfunction observed in seven of 12 of these individuals. As a group, subordinate intact females also had enlarged adrenal glands, suggestive of mechanisms that may influence atherogenesis independently. The results indicate that, in this species, ovariectomy and chronic ovarian dysfunction related to subordinate social status are associated with a more atherogenic plasma lipid pattern and abolish "female protection" against coronary artery atherosclerosis.

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Section: Necropsy and The Measurement Of Atherosclerosismentioning

confidence: 99%

Section: Necropsy and The Measurement Of Atherosclerosismentioning

confidence: 99%

Ovariectomy, social status, and atherosclerosis in cynomolgus monkeys.

Adams¹,

Kaplan²,

Clarkson³

et al. 1985

Arteriosclerosis

151

View full text Add to dashboard Cite

show abstract

“…In addition, it has been reported that postmenopausal and oophorectomized women are at higher risk for the development of CHD than premenopausal women of similar age [13][14][15] . It is well known that menopause and aging affect fasting lipid profiles.…”

Section: Introductionmentioning

confidence: 99%

Influence of Aging and Menopause on Postprandial Lipoprotein Responses in Healthy Adult Women

Nabeno

Fukuchi

Matsutani

et al. 2007

J Atheroscler Thromb

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“…Next, five representative plaque cross sections were taken from each of the two aortic segments; plaque thickness (in millimeters) was measured in these microscopic slides by using the digitizer. The plaque volume was computed (in millimeters 3 ) as the total surface area covered with plaque multiplied by the mean intimal thickness of the plaque sections. At the carotid bifurcation, one standard cross section was taken for microscopic evaluation; in taking this section, bifurcation pads (Intimal cushions") were avoided.…”

Section: Necropsy and Measurement Of Atherosclerosismentioning

confidence: 99%

Pregnancy-associated inhibition of coronary artery atherosclerosis in monkeys. Evidence of a relationship with endogenous estrogen.

Adams¹,

Kaplan²,

Koritnik³

et al. 1987

Arteriosclerosis

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We investigated the Influence of repeated pregnancy on diet-Induced atherosclerosis In cynomolgus monkeys and sought to determine If circulating endogenous reproductive steroid levels were associated with the extent of coronary artery atherosclerosis. At necropsy, females which were pregnant one or more times were found to have coronary artery atherosclerosis which was one-fourth as extensive as that of intact females which had not been pregnant. I t is well established that premenopausal white women are at low risk of coronary heart disease relative to white men of similar ages and, although direct evidence is lacking, it is widely believed that ovarian estrogen is responsible. However, it remains unproven whether coronary heart disease risk in women is influenced by conditions that influence endogenous estrogen levels.1 Studies of coronary heart disease risk in menopause, 1 " 15 an estrogen deficiency state, and pregnancy, 9 ' 16~21 a hyperestrogenic state, have produced contradictory results.With one exception, investigators addressing the relationship between pregnancy and atherosclerosis have examined only the association between number of pregnancies and incidence of coronary heart disease. The results are contradictory. In two studies it was found that there was an excess of pregnancies in women dying of coronary heart disease 16 or in women with clinical evidence of coronary heart disease (angina pectoris or electrocardiographic changes suggestive of coronary heart disease). 17 The results of three studies provided no evidence for an association between coronary heart disease risk and the number of pregnancies, 9 ' 1Si 1B and a fourth found no difference in

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Time interval from castration in premenopausal women to development of excessive coronary atherosclerosis

Cited by 145 publications

References 11 publications

Ovariectomy, social status, and atherosclerosis in cynomolgus monkeys.

Ovariectomy, social status, and atherosclerosis in cynomolgus monkeys.

Influence of Aging and Menopause on Postprandial Lipoprotein Responses in Healthy Adult Women

Pregnancy-associated inhibition of coronary artery atherosclerosis in monkeys. Evidence of a relationship with endogenous estrogen.

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