Time irreversibility of heart rate oscillations in newborns – Does it reflect system nonlinearity?

Czippelová, Barbora; Chladekova, Lenka; Uhrikova, Zuzana; Javorka, K; Zibolen, Mirko; Javorka, Michal

doi:10.1016/j.bspc.2015.03.003

Cited by 13 publications

(7 citation statements)

References 23 publications

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“…Standard linear HRV analysis by spectral analysis provides a relevant information about periodic oscillations in heart rate. The analysis is most useful when analyzing periodic oscillations, but in the complex control system output analysis -as in the case of human heart rate oscillations where nonlinear components are also included (Czippelova et al 2015) -it has only a limited value. Therefore, for the HRV analysis in newborns were recently rarely applied also nonlinear dynamics based methods, including Poincaré plot, sequence plot, Approximate Entropy (ApEn), Multiscale Entropy (MSE), symbolic dynamics methods and time irreversibility analysis (Porta et al 2001, Porta et al 2007, Javorka 2006, Czippelova et al 2015.…”

Section: Data Acquisition and Analysismentioning

confidence: 99%

Heart Rate Variability in Newborns

Javorka

Lehotska²,

Kozar³

et al. 2017

Physiol Res

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Heart rate (HR) and heart rate variability (HRV) in newborns is influenced by genetic determinants, gestational and postnatal age, and other variables. Premature infants have a reduced HRV. In neonatal HRV evaluated by spectral analysis, a dominant activity can be found in low frequency (LF) band (combined parasympathetic and sympathetic component). During the first postnatal days the activity in the high frequency (HF) band (parasympathetic component) rises, together with an increase in LF band and total HRV. Hypotrophy in newborn can cause less mature autonomic cardiac control with a higher contribution of sympathetic activity to HRV as demonstrated by sequence plot analysis. During quiet sleep (QS) in newborns HF oscillations increase – a phenomenon less expressed or missing in premature infants. In active sleep (AS), HRV is enhanced in contrast to reduced activity in HF band due to the rise of spectral activity in LF band. Comparison of the HR and HRV in newborns born by physiological vaginal delivery, without (VD) and with epidural anesthesia (EDA) and via sectio cesarea (SC) showed no significant differences in HR and in HRV time domain parameters. Analysis in the frequency domain revealed, that the lowest sympathetic activity in chronotropic cardiac chronotropic regulation is in the VD group. Different neonatal pathological states can be associated with a reduction of HRV and an improvement in the health conditions is followed by changes in HRV what can be use as a possible prognostic marker. Examination of heart rate variability in neonatology can provide information on the maturity of the cardiac chronotropic regulation in early postnatal life, on postnatal adaptation and in pathological conditions about the potential dysregulation of cardiac function in newborns, especially in preterm infants.

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Section: Data Acquisition and Analysismentioning

confidence: 99%

Heart Rate Variability in Newborns

Javorka

Lehotska²,

Kozar³

et al. 2017

Physiol Res

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“…Ограничения общепринятых параметров вариабельности сердечного ритма заставляют исследователей развивать нелинейные методы изучения вегетативной регуляции сердечно-сосудистой системы у новорожденных. В частности, известен ряд работ, посвященных использованию некоторых нелинейных показателей для анализа вариабельности сердечного ритма у новорожденных [28,29]. Однако изучение только регуляции на уровне ритма сердца не позволяет оценить выраженность системных нарушений в вегетативной регуляции кровообращения, клиническое значение которых нами ранее было показано на примере взрослых пациентов с некоторыми сердечно-сосудистыми заболеваниями [17].…”

Section: Discussionunclassified

Peculiarities of Heart Rate Variability in Newborns

Панина¹,

Kiselev²,

Боровкова³

et al. 2018

Ross. vestn. perinatol. pediatr.

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Heart rate variability values are potentially important for assessing vegetative dysfunction in children.The purpose of the research: a comparative study of spectral heart rate variability parameters and synchronization of low-frequency oscillations, characterizing baroreflex in the vegetative regulation of the cardiovascular system in healthy newborns and adults.15 healthy newborns and 60 healthy individuals in the age of 18-34 years old were included in the study. We performed synchronous recording of electrocardiograms and photoplethysmograms with 10 minutes duration, at rest. Were evaluated spectral heart rate variability indices and the index of synchronization of low-frequency oscillations in heart rate variability and photoplethysmograms (S index).Results. In newborns, the peak of low-frequency oscillations was predominantly in the range 0.07–0.09 Hz, and high frequency 0.40–0.50 Hz. Newborns had lower LF% values than adults: 22.8 (14.1, 29.4) vs 32.9 (25.1, 41.9) (p=0.009). The S index in newborns was 20.1 (16.9, 26.5)%, and 33.2 (21.2, 45.4)% in healthy adults (p=0.023).Conclusion. We have first demonstrated that the interaction of baroreflex regulation of heart rhythm and peripheral blood filling in healthy newborns is characterized by lower values of S index, than in healthy adults, which can be explained by the immaturity of the vegetative regulatory elements of the cardiovascular system.

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“…There is one more aspect to HRA as an analytical method, which may be considered its weakness, namely, that in its variance-based form it is usually defined for groups of people rather than individuals. There are simulation and surrogate data-based approaches, like the ones presented by Chladekova et al (2012) and Czippelova et al (2015), which are able to test whether a single recording is asymmetric or not. For formal statistical tests, only groups of recordings can be tested for the existence of asymmetry.…”

Section: Testing Heart Rate Asymmetry In Long Nonstationary 24 Hour R...mentioning

confidence: 99%

Testing heart rate asymmetry in long, nonstationary 24 hour RR-interval time series

et al. 2019

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Objective: Heart rate asymmetry is a phenomenon in which the contribution of heart rate decelerations to short-term heart rate variability is greater than that of accelerations, and the contribution of accelerations to long-term and total variability is greater than that of decelerations. This has been established for short, stationary recordings, so our aim is to do it for long recordings. Approach: In this paper, we analyze heart rate asymmetry in 87 long, 24 h electrocardiogram Holter recordings from healthy people. We show that in the whole recording all types of asymmetry are observable, clear and highly statistically significant. To analyze the local changes of asymmetry in time, we analyzed the recordings by disjoint jumping windows of 300 beats. Main results: This analysis revealed that the local, averaged measures of all types of asymmetry also demonstrate its presence which is highly statistically significant. Additionally, we introduce in this paper a statistical test for asymmetry in a single long recording, as opposed to the current approach in which whole groups are tested. We do this by introducing the proportion of time spent in asymmetry for each recording and using it in the binomial tests. Significance: We found that for all the recordings most of the time is spent in asymmetry.

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Time irreversibility of heart rate oscillations in newborns – Does it reflect system nonlinearity?

Cited by 13 publications

References 23 publications

Heart Rate Variability in Newborns

Heart Rate Variability in Newborns

Peculiarities of Heart Rate Variability in Newborns

Testing heart rate asymmetry in long, nonstationary 24 hour RR-interval time series

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