“Time Is out of Joint” in Pluripotent Stem Cells: How and Why
Francesca Agriesti,
Olga Cela,
Nazzareno Capitanio
Abstract:The circadian rhythm is necessary for the homeostasis and health of living organisms. Molecular clocks interconnected by transcription/translation feedback loops exist in most cells of the body. A puzzling exemption to this, otherwise, general biological hallmark is given by the cell physiology of pluripotent stem cells (PSCs) that lack circadian oscillations gradually acquired following their in vivo programmed differentiation. This process can be nicely phenocopied following in vitro commitment and reversed … Show more
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