In this paper, an integrated workflow aimed at optimizing aquifer monitoring and management through time-lapse Electric Resistivity Tomography (TL-ERT) combined with a suite of predictive algorithms is discussed. First, the theoretical background of this approach is described. Then, the proposed approach is applied to real geoelectric datasets recorded through experiments at different spatial and temporal scales. These include a sequence of cross-hole resistivity surveys aimed at monitoring a tracer diffusion in a real aquifer as well as in a laboratory experimental set. Multiple predictive methods were applied to both datasets, including Vector Autoregressive (VAR) and Recurrent Neural Network (RNN) algorithms, over the entire sequence of ERT monitor surveys. In both field and lab experiments, the goal was to retrieve a determined number of “predicted” pseudo sections of apparent resistivity values. By inverting both real and predicted datasets, it is possible to define a dynamic model of time-space evolution of the water plume contaminated by a tracer injected into the aquifer system(s). This approach allowed for describing the complex fluid displacement over time conditioned by the hydraulic properties of the aquifer itself.