In this paper, we compare 4D seismic interpretations of CO 2 plume evolution with fluid-flow numerical simulation results for Cranfield, Mississippi. Historic pressure trends, oil and gas production rates, and current CO 2-EOR production data from the field were history matched, and a tuned model was used for predictive simulations. For CO 2-EOR operations, numerical simulation results of the CO 2 plume distribution and CO 2 first arrival (breakthrough) times in production wells were compared to the available field data. Three interpretations of 4D seismic data show discrepancies on the edges of the seismic survey, and along the sealing fault, where numerical simulations show high CO 2 saturations. In areas between these two limits, the match between simulation and 4D seismic interpretation improves. In addition, for most of the production wells, comparison of the breakthrough time of CO 2 showed a reasonable match. The tuned model was then used to predict reservoir response and storage capacity in different field development scenarios under CO 2 injection. We compared hypothetical scenarios where the operator transitions from CO 2-EOR to CO 2 injection without oil production (CO 2-EORT) when oil production is $ Abbreviations used in this paper: EOR (enhanced oil recovery), EORT (enhanced oil recovery transition), VRR (voidage replacement ratio), CCS (carbon dioxide capture and storage).