2019
DOI: 10.1111/jne.12798
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Time‐of‐day‐dependent sensitivity of the reproductive axis to RFamide‐related peptide‐3 inhibition in female Syrian hamsters

Abstract: In spontaneously ovulating rodent species, the timing of the luteinising hormone (LH) surge is controlled by the master circadian pacemaker in the suprachiasmatic nucleus (SCN). The SCN initiates the LH surge via the coordinated control of two opposing neuropeptidergic systems that lie upstream of the gonadotrophin‐releasing hormone (GnRH) neuronal system: the stimulatory peptide, kisspeptin, and the inhibitory peptide, RFamide‐related peptide‐3 (RFRP‐3; the mammalian orthologue of avian gonadotrophin‐inhibito… Show more

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Cited by 6 publications
(7 citation statements)
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“…In nocturnal species, such as hamsters, studies on the role of GnIH frequently resulted in conflicting results, with both stimulatory and inhibitory effects reported ( 96 , 97 ). This is possibly due to the contrasting role of melatonin in these species, with elevated levels during the dark phase contributing to heightened activity.…”
Section: Gnih and Its Receptor In The Brain Involvement In Multiple Neuroendocrine Systemsmentioning
confidence: 99%
“…In nocturnal species, such as hamsters, studies on the role of GnIH frequently resulted in conflicting results, with both stimulatory and inhibitory effects reported ( 96 , 97 ). This is possibly due to the contrasting role of melatonin in these species, with elevated levels during the dark phase contributing to heightened activity.…”
Section: Gnih and Its Receptor In The Brain Involvement In Multiple Neuroendocrine Systemsmentioning
confidence: 99%
“…Relatedly, it is also possible that TRF enhances or activates upstream inhibitors of the LH surge generator circuitry, though this remains to be tested. This possibility is supported by observations that FOS protein (a marker of heightened neuronal activation) is induced in RFRP3 neurons of the DMH in anticipation of food during TRF (Acosta-Galvan et al, 2011) and that RFRP3, a neuropeptide that inhibits GnRH secretion, released at the wrong circadian time could impede the LH surge (Gotlieb et al, 2019). Moreover, it has been documented that RFRP-3 neuronal activation, as measured by FOS induction, is normally dampened at the time of the LH surge, supporting the possibility that the surge may be modulated by inhibition/disinhibition from RFRP3 signaling (Gibson et al, 2008).…”
Section: Discussionmentioning
confidence: 83%
“…The SCN transmits a daily signal to AVPV kisspeptin neurons via AVP release (Piet et al, 2015;Jamieson et al, 2021); when E2 is high, as during proestrus, AVPV kisspeptin cells respond robustly during the early evening and activate GnRH neurons that in turn elicit the LH surge (Robertson et al, 2009;Poling et al, 2017). All of these neural populations normally exhibit a circadian rhythm in activity and/or clock gene expression (de la Iglesia et al, 2003;Resuehr et al, 2007;Robertson et al, 2009;Zhao and Kriegsfeld, 2009;Chassard et al, 2015;Gotlieb et al, 2019). Thus, conditions or treatments that cause circadian desynchrony, such as TRF, may impede normal circadian activation of the neural mechanisms generating the LH surge.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Activation of Kiss1R in GnRH neurons produces robust depolarizing currents and induces GnRH release (43)(44)(45)(46)(47). The timing of the LH surge requires the stimulatory action of kisspeptin and the removal of RFamide-related peptide 3 (RFRP-3; also known as gonadotropin-inhibitory hormone-GnIH) (48)(49)(50)(51)(52)(53). In this model, the daily afternoon increase in GnRH and LH is due to suppression of the RFRP-3 inhibitory input to the GnRH neurons by the suprachiasmatic nucleus (SCN).…”
Section: Positive Feedback the Lh Surge And Ovulationmentioning
confidence: 99%