Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex

Hight, Krista; Hallett, Heather; Churchill, Lynn; De, Alok; Boucher, Andrea; Krueger, James M.

doi:10.1016/j.brainres.2010.04.012

Cited by 18 publications

(13 citation statements)

References 45 publications

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“…Hallett et al (2010) showed that individual whisker stimulation increased local expression of sleep regulating substances (nerve growth factor and interleukin-1 beta) in somatosensory cortex, providing support for the theory of local sleep. Hight et al (2010) showed circadian rhythmicity in sleep regulating substances in both somatosensory and visual cortex, providing support for the theory of local sleep. Krueger et al (2010) showed that purines and ATP affect sleep suggesting a basis for the local, homeostatic (use dependent) drive for sleep.…”

Section: Laboratory Studies In Animalssupporting

confidence: 55%

Naturalistic Field Studies of Sleep and Performance

Belenky¹

2011

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Section: Laboratory Studies In Animalssupporting

confidence: 55%

Naturalistic Field Studies of Sleep and Performance

Belenky¹

2011

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“…151,152 Recently, Hight et al found that the expression of NGF in somatosensory cortical neurons is high during the dark phase, while it is low during the light phase. 153 On the contrary, high levels of NGF are expressed in the visual cortex during the light phase, further supporting the modulation of NGF expression in brain pathways activated by light stimuli, and therefore that changes in circulating or brain NGF and BDNF levels might reflex the light/dark cycle. Remarkably, a daily fluctuation of NGF and BDNF in human serum and plasma, also related to sex, has been found in healthy subjects.…”

Section: Ngf and Bdnf As Neuromodulators Of Chronotherapeutics Of Depmentioning

confidence: 88%

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis"

Tirassa¹,

Quartini²,

Iannitelli³

2015

CPT

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The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of circadian cycles. Light-based strategies and/or drugs acting on the circadian rhythms have widely been used in psychiatric patients characterized by mood-related disorders, but the timing and dosage use of the various treatments, although based on international guidelines, are mainly dependent on the psychiatric experiences. Further, many efforts have been made to identify biomarkers able to disclose the circadian-related aspect of diseases, and therefore serve as diagnostic, prognostic, and therapeutic tools in clinic to assess the different moodrelated symptoms, including pain, fatigue, sleep disturbance, loss of interest or pleasure, appetite, psychomotor changes, and cognitive impairments. Among the endogenous factors suggested to be involved in mood regulation, the neurotrophins, nerve growth factor, and brain-derived neurotrophic factor show anatomical and functional link with the circadian system and mediate some of light-induced effects in brain. In addition, in humans, both nerve growth factor and brain-derived neurotrophic factor have showed a daily rhythm, which correlate with the morningness-eveningness dimensions, and are influenced by light, suggesting their potential role as biomarkers for chronotypes and/or chronotherapy. The evidences of the relationship between the diverse mood-related disorders, with a specific focus on depression, and neurotrophins are reviewed and discussed herein in terms of their circadian significance, and potential translation into clinical practice.

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“…The lack of response of IL-1 β to cocaine at light onset may be due to the fact that the high levels of IL-1 β mRNA at this time have reached their maximal levels. In response to activity during the night, IL-1 β -IR cells are greater in number at light onset than at dark onset [10]. At dark onset, the low dose of cocaine also significantly increased the number of IL1 β -IR astrocytes in the PFC, NAcc and somatosensory cortices, but not in the piriform cortex.…”

Section: Discussionmentioning

confidence: 99%

“…In the brain, the central beta adrenergic receptors are involved in the activation of the cytokine, interleukin-1 β (IL1 β ), in the hypothalamus by methamphetamaine [7]. In the brain, cytokines act as sleep regulatory substances (SRSs) that are produced in response to neural activity [8–10]. Whisker stimulation increases the number of cytokine-IR cells in the somatosensory cortex.…”

Section: Introductionmentioning

confidence: 99%

Acute Cocaine Increases Interleukin-1β mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens

Cearley¹,

Blindheim

Sorg

et al. 2011

Neurochem Res

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The cytokine, interleukin-1β (IL1 β) is a sleep regulatory substance whose expression is enhanced in response to neuronal stimulation. In this study, IL1β mRNA and immunoreactivity (IR) are evaluated after acute cocaine. First, IL1β mRNA levels were measured at the start or end of the light period after saline or acute exposure to a low dose of cocaine (5 mg/kg, intraperitoneal (ip)). IL1β mRNA levels after an acute exposure to cocaine (5 mg/kg, ip) at dark onset were significantly higher than those obtained from rats sacrificed after an acute exposure to saline in the piriform and somatosensory cortex, and nucleus accumbens. Acute exposure of cocaine at 5 mg/kg at dark onset also increased the number of IL1β-immunoreactive astrocytes in layer I–V of the prefrontal cortex, somatosensory cortex and nucleus accumbens. These data suggest that IL1β mRNA and protein levels in some of the dopaminergically innervated brain regions are responsive to cocaine.

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Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex

Cited by 18 publications

References 45 publications

Naturalistic Field Studies of Sleep and Performance

Naturalistic Field Studies of Sleep and Performance

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis"

Acute Cocaine Increases Interleukin-1β mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens

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Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex

Cited by 18 publications

References 45 publications

Naturalistic Field Studies of Sleep and Performance

Naturalistic Field Studies of Sleep and Performance

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the &quot;neurotrophic hypothesis&quot;

Acute Cocaine Increases Interleukin-1β mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens

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Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis"