Time of development of tuberculosis in contacts

Teale, C.; Cundall, David; Pearson, S. Vere

doi:10.1016/s0954-6111(06)80264-7

Cited by 32 publications

(14 citation statements)

References 5 publications

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“…(4) Various studies have shown the importance of a one-or two-year clinical and radiological followup evaluation of the contacts of patients with active tuberculosis, principally those living under unfavorable socioeconomic conditions. (1,(19)(20) Nevertheless, there are other more complex methods for the diagnosis of tuberculosis, such as molecular biology analysis. However, the routine use of molecular biology techniques in the investigation of such contacts is not a feasible strategy in most developing countries in which there are a great number of cases.…”

Section: Discussionmentioning

confidence: 99%

O controle de comunicantes de tuberculose no programa de controle da tuberculose em um município de médio porte da Região Sudeste do Brasil, em 2002

Gazetta

Ruffino-Netto

Neto³

et al. 2006

J. bras. pneumol.

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OBJETIVO: Este estudo tem o objetivo de descrever as ações de controle dos comunicantes de tuberculose no Programa de Controle da Tuberculose do Município de São José do Rio Preto (SP), em 2002. MÉTODOS: Estudo descritivo, utilizando dados secundários do Sistema de Informação de Notificação de Tuberculose, prontuários e planilhas de registros do programa de controle da tuberculose. RESULTADOS: Estavam inscritos no programa 166 comunicantes intradomiciliares de tuberculose em 2002, sendo 82 do sexo masculino e 84 do feminino, com maior incidência de casos na faixa etária de 15 e 59 anos (70%); 42 tinham entre 0 e 19 anos (25,3%), 73 entre 20 e 49 anos (44%), e 44 tinham 50 anos ou mais (25,5%). Quanto ao grau de parentesco, 41 eram filhos, 29 companheiros, 22 irmãos e 15 mães do paciente índice. Com relação aos exames solicitados, observou-se que: 12% realizaram baciloscopia e/ou cultura; 100% realizaram radiografia de tórax, e destes, 2 apresentaram suspeita de tuberculose pulmonar e 5 outras afecções; 7,2% realizaram prova tuberculínica, com 4,2% de não reatores e 1,2% com enduração igual a 8 mm. Dos comunicantes examinados, 3 tiveram a doença detectada (1,8%). CONCLUSÃO: O serviço mostrou que não há uma sistematização em relação ao monitoramento do controle dos comunicantes de pacientes com tuberculose.

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Section: Discussionmentioning

confidence: 99%

O controle de comunicantes de tuberculose no programa de controle da tuberculose em um município de médio porte da Região Sudeste do Brasil, em 2002

Gazetta

Ruffino-Netto

Neto³

et al. 2006

J. bras. pneumol.

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“…This is not a very high rate when compared to a study conducted in a junior school in south-eastern England, where TB was diagnosed in 9% of contacts [2]. In several retrospective contact tracing studies, 90% or more of TB cases were identified within the first 12 months after identification of the index case [17,18]. We were not able to follow up the patients for this length of time because of lack of cooperation of the TB cases and lack of a screening programme in our country, which may explain why our result is lower than the other studies.…”

Section: Discussionmentioning

confidence: 67%

Contact tracing of a 15-year-old girl with smearnegative pulmonary tuberculosis in Tehran

Baghaie¹,

Khalilzadeh²,

Mr³

et al. 2012

East Mediterr Health J

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Early detection of tuberculosis (TB) cases and supervised treatment are vital for control of the disease. To assess TB transmission from a sputum smear-negative pulmonary TB case, the contacts of a 15-year-old Iranian girl diagnosed with smear-negative TB in 2010 were traced. In all, 52 classmates and close friends and 15 school staff were screened by tuberculin skin test and chest X-ray. Those with a positive skin test or abnormal chest X-ray were further evaluated by chest spiral computed tomography (CT) scan and triple gastric washing. All classmates and close friends were Iranian and female. Of the 52 girls, 17 (32%) had latent infection (either positive skin test or abnormal chest X-ray) and 3 (5.7%) had active TB (abnormal CT or positive culture additional to positive skin test or abnormal X-ray). None of the staff had abnormal findings. Contact tracing should be considered for contacts of all children with symptomatic pulmonary TB, even those who are smear-negative.

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“…This disparity in the disease progression rate may result from the different lengths of follow-up performed in these studies. In our study, the mean duration of follow up was 15.1±35.9 months, whereas other studies used a duration of 24–60 months [30], [33], [35], [36], [37].…”

Section: Discussionmentioning

confidence: 86%

“…In two other studies conducted in Brazil, the rate of progression ranged from 2.3% to 3.2% [30], [31]. In countries with a low disease load, the rate of progression ranges from 0.51% to 7.6% [32], [33], [34], [35], [36]. This disparity in the disease progression rate may result from the different lengths of follow-up performed in these studies.…”

Section: Discussionmentioning

confidence: 99%

Impact of Latent Infection Treatment in Indigenous Populations

2013

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The aims of the present study were to identify risk factors associated with latent tuberculosis (TB), examine the development of active disease among contacts, and assess the effectiveness of treating latent infection in indigenous Brazilians from January 2006 to December 2011. This was a retrospective study consisting of 1,371 tuberculosis contacts, 392 of whom underwent treatment for latent infection. Morbidity-from-TB data were obtained from the Information System for Disease Notification (SINAN) database, and the contacts’ data were collected from the clinical records using forms employed by Special Department of Indigenous Health (SESAI) multidisciplinary teams, according to SESAI’s instructions. The variables that were associated with latent infection among the contacts were age (odds ratio [OR]: 1.03; 95% confidence interval [CI]: 1.02–1.04) and close contact with a smear-positive index case (OR: 2.26, 95% CI: 1.59–3.22). The variables associated with the development of active TB among the contacts were a tuberculin skin test (TST) ≥10 mm (relative risk [RR]: 1.12, 95% CI: 1.07–1.17), age (RR: 1.01, 95% CI: 1.00–1.03), and treatment of latent infection (RR: 0.03, 95% CI: 0.01–0.27). The estimated number of latent infection treatments needed to prevent one case of active TB among the contacts was 51 treatments (95% CI: 33–182). In contacts with TST ≥10 mm, 10 (95% CI: 6–19) latent infection treatments were necessary to prevent one case of active TB. Age and close contact with a smear-positive index case were associated with latent TB. Screening with TST is a high priority among individuals contacting smear-positive index cases. Age and TST are associated with the development of active TB among contacts, and treatment of latent infection is an effective measure to control TB in indigenous communities.

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Time of development of tuberculosis in contacts

Cited by 32 publications

References 5 publications

O controle de comunicantes de tuberculose no programa de controle da tuberculose em um município de médio porte da Região Sudeste do Brasil, em 2002

O controle de comunicantes de tuberculose no programa de controle da tuberculose em um município de médio porte da Região Sudeste do Brasil, em 2002

Contact tracing of a 15-year-old girl with smearnegative pulmonary tuberculosis in Tehran

Impact of Latent Infection Treatment in Indigenous Populations

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