2019
DOI: 10.1021/acs.analchem.9b02756
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Time-of-Sight Liquid Flow Measurements in the Low Nanoliters per Minute Scale

Abstract: We describe an affordable and robust measurement technique applicable to nanoscale liquid flow. The approach can provide good precision (<1% RSD) in the 1.5–15 nL/min flow range. The motion of a conductive/nonconductive immiscible segmental interface in a capillary is followed by an admittance detector. The conductive marker segment, e.g., a salt solution, is protected on both sides from the principal flow stream by immiscible guard segments, typically a fluorocarbon (FC) liquid, of significantly greater imped… Show more

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Cited by 6 publications
(1 citation statement)
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“…Among various flow sensors, the thermal flow sensor is the most common due to its simple structure and simple electric readout. The hot-wire flow sensor uses one simple temperature sensor with a heater, while the thermal flow sensor uses two temperature sensors with a heater between them, which uses the heat source, the heater structure, or the changes in the location and amount of temperature sensors via the conversion method of the calorimetric principle [14,15]. Thermal MEMS (micro-electro-mechanical systems) flow sensors are composed of a heater and temperature sensors fabricated on a thin film (membrane).…”
Section: Introductionmentioning
confidence: 99%
“…Among various flow sensors, the thermal flow sensor is the most common due to its simple structure and simple electric readout. The hot-wire flow sensor uses one simple temperature sensor with a heater, while the thermal flow sensor uses two temperature sensors with a heater between them, which uses the heat source, the heater structure, or the changes in the location and amount of temperature sensors via the conversion method of the calorimetric principle [14,15]. Thermal MEMS (micro-electro-mechanical systems) flow sensors are composed of a heater and temperature sensors fabricated on a thin film (membrane).…”
Section: Introductionmentioning
confidence: 99%