Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations

Abstract

The aim was to find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search a correlation between impact of symptoms evaluated with ICSI-ICPI and the presence of comorbid conditions associated with BPS/IC. Ninety-seven consecutive patients underwent cystoscopy under general anesthesia to classify those cases suspected of being affected from BPS/IC. Three cold bladder biopsies were taken including detrusor muscle. Statistical analysis showed significant correlation between IC/BPS duration and the presence of Hunner's lesions (P<0.023). Hunner's lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be items related to IC/BPS duration. Thus an early diagnosis allows to start an appropriate therapeutic approach and prevent a more severe evolution of this multifaceted painful syndrome. Our study shows a correlation between time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. IC/BPS duration seem to correlate with the presence of associated diseases.

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

“…So far, there is no cure for IC/BPS, 30 which means that patients have to learn to live with the symptoms throughout their life, often with a tendency to accumulate comorbidities with time. 110 It will be worth refining the preclinical models to obtain more insights into these aspects, eg, by modulating the strength and duration of a trigger to induce a potentially milder but chronic disease state. A surprisingly high proportion of publications within the instillation of irritants subcategory used the cyclophosphamide model (48% of publications).…”