Time perception impairment following thalamic stroke: A case study

Mole, J; Winegardner, Jill; Malley, Donna; Fish, Jessica

doi:10.1080/09602011.2017.1383273

Cited by 5 publications

(7 citation statements)

References 33 publications

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“…This was likely due to the activation of the primary motor cortex for those “Response” trials while not for the “No-response” trials, and the sequential structure of the NR, which indicates that the upcoming trial is “Response” before the cue appears. The thalamus plays a key role in the cortico-thalamic-basal ganglia timing circuits (Mole et al 2018; Yin et al 2022).…”

Section: Resultsmentioning

confidence: 99%

“…This was observed within a network associated with cognitive control and response preparation (Ridderinkhof et al 2004; Dijkerman and de Haan 2007; Fitzgerald et al 2010), which includes regions like the right posterior-medial frontal, the left postcentral gyrus, and the left precuneus. Additionally, the right thalamus, a critical component of cortico-thalamic-basal ganglia timing circuits (Mole et al 2018; Yin et al 2022), also showed activation. After a passive-viewing trial with no response demands, the response preparation network and cortico-thalamic-basal ganglia timing circuits were better primed for the upcoming trial.…”

Section: Discussionmentioning

confidence: 99%

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Neural mechanisms of sequential dependence in time perception: The impact of prior task and memory processing

Cheng

Glasauer

et al. 2023

Preprint

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Our perception and decision-making are susceptible to prior context, as seen in sequential dependence where our judgment of stimulus magnitude is biased toward what we experienced in previous trials. While sequential bias in the spatial domain has been extensively studied, less is known about it for time perception. Furthermore, it is still debatable whether sequential bias arises during perceptual or post-perceptual stages. To investigate this, we conducted functional magnetic resonance imaging (fMRI) on twenty-one participants performing a timing task, which involved two phases - duration encoding and duration reproduction. Participants had to remember the duration of the green coherent motion and wait for a cue to reproduce the perceived duration. The cue could be either Go or No-go. For the No-go cue, participants should only passively view the display. We observed that the reproduction error was positively correlated with the prior duration only when the preceding task was also active reproduction. In contrast, encoding the prior duration without reproduction was insufficient to induce sequential bias. Neurally, we observed activated timing-related networks, such as striato-thalamo-cortical circuits, and performance monitoring networks when the trial sequence implicitly predicted a Go trial. When action required a post cue, the right frontal gyrus, associated with response inhibition, became activated. Importantly, the hippocampus showed sensitivity to sequential bias and its activation was negatively correlated with the individuals sequential bias following active reproduction trials. These findings highlight the crucial role of striato-thalamo-cortical networks in time perception, as well as memory networks in sequential biases at the post-perceptual stage.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neural mechanisms of sequential dependence in time perception: The impact of prior task and memory processing

Cheng

Glasauer

et al. 2023

Preprint

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“…It focused on a very specific type of stroke, that is, thalamic stroke. In the study, Mole et al (2017) used a case study approach to explore time perception impairment following a thalamic stroke. The case study participant was tested with the results compared to two control groups.…”

Section: Discussionmentioning

confidence: 99%

The Lived Experience of Serious Stroke Survival: A Hermeneutic Phenomenological Case Study

Champlin

Hunt

2023

Rehabilitation Nursing

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Purpose: The aim of this study was to describe the lived experiences of a serious stroke survivor. Design: This is a hermeneutic phenomenological case study. Methods: Data were collected via observations and conversations during 75 visits, 14 brief audiotaped interviews, field notes, and conversations with family members, close friends, and care providers. Findings: Seven themes emerged that form the general structure of the lived experience of surviving a serious stroke. These themes were organized around four fundamental existential themes including space, time, body, and relationships. Clinical Relevance to the Practice of Rehabilitation Nursing: Spend intentional time with patients beyond the initial stroke rehabilitation period to better understand the experience, individualize care, identify meaningful activities previously engaged in, and identify people who may be willing to partner with them to continue participation in the meaningful activities. Conclusion: Hermeneutic phenomenology allows the essence of the stroke survival experience to be revealed and contributes to better understanding of the phenomenon.

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“…We found time perception deficits to be slightly more common in strokes affecting the right hemisphere (219 vs. 199 in the left hemisphere). Numerous locations were associated with time perception deficits, namely the thalamus ( 38 – 41 ), insula ( 43 ), basal ganglia ( 42 ), cerebellum ( 21 – 25 ) and cortical structures (dorsolateral prefrontal cortex ( 24 , 25 , 27 , 28 , 32 , 36 , 44 , 47 ), parietal cortex ( 32 , 36 , 44 – 47 ), including supramarginal ( 26 , 28 , 33 ) and angular gyri ( 28 ), temporal cortex ( 26 , 32 , 36 , 46 , 47 ). These locations correspond to those commonly reported in time perception studies with functional brain MRI in healthy participants ( 5 , 49 ).…”

Section: Discussionmentioning

confidence: 99%

“…The impact of stroke lesions in the thalamus support the role that this structure has on time perception mechanisms by being a part of the circuitry involving the cerebellum, basal ganglia and cerebral cortex ( 10 ), namely the mediodorsal and anteromedial nuclei, that constitute the “limbic thalamic nuclei” ( 53 ). These structures are probably essential for memory formation that translates into the notion of time intervals ( 41 ). Previous studies suggest that these nuclei have important projections, namely dorsolateral prefrontal cortex and receive basal ganglia projections ( 54 ).…”

Section: Discussionmentioning

confidence: 99%

Time perception changes in stroke patients: A systematic literature review

et al. 2022

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IntroductionTime perception comprises the subjective experience of passing of time and of the duration of an event. Although already described in some neurological and psychiatric conditions, there is a paucity of details regarding this neurocognitive change in stroke patients. We aimed to describe time perception dysfunction in stroke patient.MethodsWe performed a systematic review of the literature in Pubmed, PsycInfo and EMBASE including manuscripts from their inception until December 2020. We collected data regarding the type of time perception that was detected, type of stroke, most common location of lesions, evaluation tests that were used and time of evaluation after stroke onset.ResultsA total of 27 manuscripts were selected, concerning a total of 418 patients (n = 253 male; 60.5%). Most manuscripts (n = 21) evaluated patients with ischaemic lesions (n = 407; 97.4%). The majority referred to evaluations between 2 months and seven years after stroke. Underestimation in temporal evaluation in sub- and supra-second was the most common dysfunction (n = 165; 41.7%). Overestimation of time (n = 116; 27.8%) and impaired time interval comparison (n = 88; 22.2%) were also found. Most patients had right hemisphere lesions (n = 219 patients; 52.4%). Common reported lesion locations included the thalamus, insula, basal ganglia, dorsolateral prefrontal cortex, parietal cortex including supramarginal, angular gyrus and right inferior parietal cortex and cerebellum.ConclusionThere are multiple stroke locations associated with time perception dysfunction, which highlights the complex system involved in time perception. There is still scarce knowledge about specific time perception deficits after stroke. Most studies rely in psychometric analysis without clear clinical and functional translation, namely regarding impact on daily activities.

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Time perception impairment following thalamic stroke: A case study

Cited by 5 publications

References 33 publications

Neural mechanisms of sequential dependence in time perception: The impact of prior task and memory processing

Neural mechanisms of sequential dependence in time perception: The impact of prior task and memory processing

The Lived Experience of Serious Stroke Survival: A Hermeneutic Phenomenological Case Study

Time perception changes in stroke patients: A systematic literature review

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