2020
DOI: 10.1038/s41598-020-61711-x
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Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches

Abstract: Despite the tremendous importance of so-called ionizing radiations (X-rays, accelerated electrons and ions) in cancer treatment, most studies on their effects have focused on the ionization process itself, and neglect the excitation events the radiations can induce. Here, we show that the excited states of DnA exposed to accelerated electrons can be studied in the picosecond time domain using a recently developed cathodoluminescence system with high temporal resolution. our study uses a table-top ultrafast, UV… Show more

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Cited by 5 publications
(5 citation statements)
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“…67 Up to this point, DNA fluorescence induced by optical (UVC, UVB, and UVA) excitation has been considered, but a very recent study showed that DNA fluorescence can also be triggered by low-energy electrons. 82 This opens up a new field for probing the very complex excited-state topology of DNA and potentially using its intrinsic fluorescence to detect harmful high-energy ionizing radiation.…”
Section: ■ Conclusion and Perspectivesmentioning
confidence: 99%
“…67 Up to this point, DNA fluorescence induced by optical (UVC, UVB, and UVA) excitation has been considered, but a very recent study showed that DNA fluorescence can also be triggered by low-energy electrons. 82 This opens up a new field for probing the very complex excited-state topology of DNA and potentially using its intrinsic fluorescence to detect harmful high-energy ionizing radiation.…”
Section: ■ Conclusion and Perspectivesmentioning
confidence: 99%
“…For instance, localized surface plasmon (LSP) and surface plasmon polariton (SPP) have been visualized [8,12,13]. The lifetime measurement using CL typically requires a large-scale measurement system that integrates a pulsed electron gun as an excitation source [14,15] and a synchronized detector, which is especially complicated for STEM with high acceleration voltages.…”
Section: Introductionmentioning
confidence: 99%
“…127,128 In recent years, time-resolved CL with pulsed electron beams in SEM has enabled the dynamic study of exciton diffusion, 21,24,129 carrier relaxation, 20,130−132 and excited states of DNA. 133 Currently, time-resolved CL studies performed in TEM have also been reported, 26,27 making progress toward elucidating structure−function relations at atomic scales. As an example of this advance, Kim et al showed that the color centers in nanodiamonds can be pumped through charge transfer among these centers under electronbeam excitation.…”
Section: Review Of CL Nanoscopymentioning
confidence: 99%
“…Using a gold photocathode driven by laser pulses and a streak camera for time-resolved detection, they revealed the correlation of local carrier dynamics in GaAs nanostructures with the surface morphology. In parallel with the developments in the laser-driven cathode, advances in ultrafast beam blankers promise a flexible and easily integrated method to generate electron pulses with a broad range of pulse widths and repetition rates, while keeping a good spatial resolution with a typical duration of tens of picoseconds. , In recent years, time-resolved CL with pulsed electron beams in SEM has enabled the dynamic study of exciton diffusion, ,, carrier relaxation, , and excited states of DNA . Currently, time-resolved CL studies performed in TEM have also been reported, , making progress toward elucidating structure–function relations at atomic scales.…”
Section: Review Of CL Nanoscopymentioning
confidence: 99%