Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet

Abstract

Non-alcoholic fatty liver disease (NAFLD), a condition characterized by the accumulation of fat in the liver, is estimated to be the most common liver disease worldwide. Obesity is a major risk factor and contributor, and, accordingly, weight loss can improve NAFLD. Previous studies in preclinical models of diet-induced obesity and fatty liver disease have shown the independent benefits of resistance exercise training (RT) and time-restricted feeding (TRF) in preventing weight gain and hepatic build-up of fat. Here, we tested the combined effect of TRF and RT on obesity and NAFLD in mice fed a high-fat diet. Our results showed that both TRF - 8h food access in the active phase - and RT - consisting of three weekly sessions of ladder climbing - attenuated body weight gain, improved glycemic homeostasis, and decreased the accumulation of lipids in the liver. TRF combined with RT improved respiratory exchange rate, energy expenditure, and mitochondrial respiration in the liver. Furthermore, gene expression analysis in the liver revealed lower mRNA expression of lipogenesis and inflammation genes along with increased mRNA of fatty acid oxidation genes in the TRF+RT group. Importantly, combined TRF+RT proved more efficient in preventing obesity and metabolic disorders. In conclusion, TRF and RT exert complementary or additive actions compared to isolated interventions, with significant effects on metabolic disorders and NAFLD in mice.

Effects of Supplementation with Microalgae Extract from Phaeodactylum tricornutum (Mi136) to Support Benefits from a Weight Management Intervention in Overweight Women

“…In the present study, 12 weeks of walking, resistance training, and the maintenance of a modest decrease in energy intake promoted significant weight loss (−1.88 [−0.6, −3.2] kg, p = 0.007), fat loss (−2.4 [−1.3, −3.5] kg, p < 0.001), and a reduction in body fat percent (−2.43 [−1.3, −3.5] %, p < 0.001) while increasing FFM (0.54 [0.06, 1.01] kg, p = 0.03) in both treatment groups. These findings are consistent with our prior research [10,36,[72][73][74][75][76][77] and others [78][79][80][81][82][83] that showed that this type of exercise and dietary intervention promotes a reduction in energy intake and fat loss while maintaining or increasing muscle mass and/or REE. However, beyond a trend toward a greater reduction in energy and a significant reduction in fat intake, supplementation with fucoxanthin did not promote a significant increase in REE or greater weight and fat loss compared with those ingesting a placebo.…”

6-week time-restricted eating improves body composition, maintains exercise performance, without exacerbating eating disorder in female DanceSport dancers

“…TRE significantly reduced FM in this study, potentially because of its impact on circadian rhythms, thereby influencing energy expenditure rates [ 35 , 36 ]. When combined with exercise, TRE has the potential to enhance lipid metabolism, thereby contributing to alterations in glucose and fat consumption rates [ 37 , 38 ]. Although the main increase in lipid metabolism occurs between 18 and 24 h of acute fasting [ 39 ], significant changes can occur during long-term intervention with shorter fasting durations.…”