Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway

Zhai, Qiaocheng; Zeng, Yizhun; Gu, Yue; Li, Zhihao; Zhang, Tao; Yuan, Baoshi; Wang, Tao; Yan, Jie; Qin, Han; Yang, Ling; Chen, Xiaowei; Vidal-Puig, António; Xu, Ying

doi:10.1016/j.isci.2022.104267

Cited by 9 publications

(6 citation statements)

References 55 publications

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“…Besides, time-restricted feeding is also used to entrain the SCN clock. One study found that a time-restricted feeding at ZT0-4 (zeitgeber time) produced a significant long-term delay of the activity offset in mice [ 74 ] , further indicating an important role for the insulin-like growth factor 2 (IGF2)/potassium chloride cotransporter 2 (KCC2) signaling in these behavioral changes. It is also suggested that the SIRT1/PGC-1α amplifying loop is involved in the entraining effect of restricted feeding [ 56 ] , which involves the activation of PGC-1α by stimulation of free fatty acid and β-hydroxybutyrate synthesis, or SIRT1-associated modulation of the NADH/NAD + ratio [ 17 , 75 ] .…”

Section: Irisin As An Integrator Of Photic and Non-photic Entrainmentmentioning

confidence: 99%

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review

Inyushkin,

Poletaev,

Inyushkina

et al. 2024

J Biomed Res

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In mammals, the timing of physiological, biochemical and behavioral processes over a 24-h period is controlled by circadian rhythms. To entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus to a precise 24-h rhythm, environmental zeitgebers are used by the circadian system. This is done primarily by signals from the retina via the retinohypothalamic tract, but other cues like exercise, feeding, temperature, anxiety, and social events have also been shown to act as non-photic zeitgebers. The recently identified myokine irisin is proposed to serve as an entraining non-photic signal of exercise. Irisin is a product of cleavage and modification from its precursor membrane fibronectin type Ⅲ domain-containing protein 5 (FNDC5) in response to exercise. Apart from well-known peripheral effects, such as inducing the "browning" of white adipocytes, irisin can penetrate the blood-brain barrier and display the effects on the brain. Experimental data suggest that FNDC5/irisin mediates the positive effects of physical activity on brain functions. In several brain areas, irisin induces the production of brain-derived neurotrophic factor (BDNF). In the master clock, a significant role in gating photic stimuli in the retinohypothalamic synapse for BDNF is suggested. However, the brain receptor for irisin remains unknown. In the current review, the interactions of physical activity and the irisin/BDNF axis with the circadian system are reconceptualized.

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Section: Irisin As An Integrator Of Photic and Non-photic Entrainmentmentioning

confidence: 99%

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review

Inyushkin,

Poletaev,

Inyushkina

et al. 2024

J Biomed Res

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“…This protocol can be used to explore the long-term response of SCN to external environmental stimulation. For complete details on the use and execution of this protocol, please refer to Zhai et al. (2022) .…”

mentioning

confidence: 99%

“…For complete details on the use and execution of this protocol, please refer to Zhai et al. (2022) .…”

mentioning

confidence: 99%

Long-term SCN calcium signal recording in freely moving mice

Zhai

Zeng

et al. 2022

STAR Protocols

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“…The finding that daytime-restricted feeding alters circadian swimming rhythms mirrors observations in terrestrial mammals, in which time-restricted feeding can alter behavioral rhythms and clock function (Reinke & Asher, 2019;Zhai et al, 2022). Although NF corresponds to the "natural" situation, DF is commonly used for zooplankton cultures for practical reasons.…”

Section: Implications For Our Understanding Of Dvm In Natural Populat...mentioning

confidence: 76%

“…Specifically, irregular or abnormal feeding patterns disrupt metabolic homeostasis. This is because, in mammals, circadian clocks drive daily feeding rhythms, which in turn reinforce circadian rhythms in both central and peripheral clocks (Tahara & Shibata, 2013;Zhai et al, 2022). Of particular note are studies showing that rats fed during the day (their normal resting period) exhibit pronounced weight gain compared to rats fed at night, despite similar caloric intake and activity levels (Arble et al, 2009).…”

Section: Circadian Behavior In Multi-zeitgeber Systems (Aka the Real ...mentioning

confidence: 99%

Exploring circadian rhythms, food intake, and their interactions in marine invertebrates

Berger

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Circadian rhythms and energy metabolism are critical and interconnected components of animal physiology. Metabolic inputs like time of feeding modulate circadian clocks and behavioral and molecular rhythms. In turn, circadian clocks regulate metabolic processes, allowing animals to optimize energy usage on daily timescales. On longer timescales, animals require physiological responses to tolerate variation in food availability. Most of our mechanistic knowledge of these processes comes from terrestrial mammals and insects, while there are major knowledge gaps for marine invertebrates. My dissertation focuses on the interactions of circadian rhythms and metabolism in three marine invertebrate systems using a combination of behavioral, molecular, and bioinformatic approaches. In Chapter 2, to understand how sensory signals are integrated into circadian clocks, I test the effects of various light and temperature regimes on circadian rhythms in the sea anemone Nematostella vectensis. Misaligned light and temperature cycles severely disrupt behavioral rhythms and substantially alter the rhythmic transcriptome, particularly the expression of genes mediating metabolic processes. This illustrates how interactions between environmental cues shape circadian behavior and physiology. In Chapter 3, I develop a high-throughput behavioral system to study diel vertical migration (DVM) in the copepod Acartia tonsa. DVM is driven by tradeoffs related to food availability, but we do not fully understand how food availability affects this circadian process. Using high-resolution tracking software, I find that Acartia possesses group-level DVM-like circadian rhythms in the lab, and that these swimming rhythms are altered by time-restricted feeding. This illustrates that food availability can impact DVM via effects on circadian clocks. In Chapter 4, I analyze how polar copepods respond to starvation at the molecular level. I find that two species with distinct dietary strategies partially share a genetic toolkit to respond to starvation, whereas differences in their starvation responses may reflect different modes of lipid storage. I also use evolutionary analyses to show that starvation response genes are under selective constraint, underlining their importance to organismal fitness. In aggregate, this thesis provides insights into the circadian rhythms of marine organisms, explores how metabolism modulates circadian rhythms, and sheds lights on the physiological consequences of food availability in zooplankton.

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Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway

Cited by 9 publications

References 55 publications

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review

Long-term SCN calcium signal recording in freely moving mice

Exploring circadian rhythms, food intake, and their interactions in marine invertebrates

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