Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice

Hou, Tianfei; Su, Wen; Duncan, Marilyn J.; Olga, V Akulova; Guo, Zhenheng; Gong, Ming

doi:10.1073/pnas.2015873118

Cited by 34 publications

(52 citation statements)

References 60 publications

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“…Previous studies demonstrated that SNS activity is suppressed during fasting and enhanced after feeding ( 11 – 15 ). Consistent with these studies, we recently reported that the non-dipping BP is associated with diminished rhythms of food intake and SNS activity in diabetic db/db mice ( 16 ). Importantly, we demonstrated that aligning food availability with the standard light-dark cycle by dark-phase TRF, which limits food availability only to the active dark phase, restores BP and SNS activity rhythms in db/db mice ( 16 ).…”

Section: Introductionsupporting

confidence: 77%

“…Consistent with these studies, we recently reported that the non-dipping BP is associated with diminished rhythms of food intake and SNS activity in diabetic db/db mice ( 16 ). Importantly, we demonstrated that aligning food availability with the standard light-dark cycle by dark-phase TRF, which limits food availability only to the active dark phase, restores BP and SNS activity rhythms in db/db mice ( 16 ). However, whether SNS activity rhythm serves as the mechanistic linkage between light-phase TRF and BP circadian rhythm alteration has not been investigated.…”

Section: Introductionsupporting

confidence: 77%

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Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration

Hou

Chacon

et al. 2022

Front. Nutr.

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Disruption of blood pressure (BP) circadian rhythm, independent of hypertension, is emerging as an index for future target organ damage and is associated with a higher risk of cardiovascular events. Previous studies showed that changing food availability time alters BP rhythm in several mammalian species. However, the underlying mechanisms remain largely unknown. To address this, the current study specifically investigates (1) the relationship between rhythms of food intake and BP in wild-type mice; (2) effects of light-phase time-restricted feeding (TRF, food only available during light-phase) on BP circadian rhythm in wild-type and diabetic db/db mice; (3) the roles of the autonomic system and clock gene in light-phase TRF induced changes in BP circadian rhythm. Food intake and BP of C57BL/6J and db/db mice were simultaneously and continuously recorded using BioDAQ and telemetry systems under ad libitum or light-phase TRF. Per2 protein daily oscillation was recorded in vivo by IVIS spectrum in mPer2Luc mice. Autonomic nerve activity was evaluated by heart rate variability, baroreflex, urinary norepinephrine (NE) and epinephrine (Epi) excretion, and mRNA expressions of catecholamines biosynthetic and catabolic enzymes, and alpha-adrenergic receptors in mesenteric resistance arteries. We found that in wild-type mice, the BP level was correlated with the food intake temporally across the 24 h. Reversing the feeding time by imposing light-phase TRF resulted in reverse or inverted BP dipping. Interestingly, the net changes in food intake were correlated with the net alteration in BP temporally under light-phase TRF. In db/db mice, light-phase TRF worsened the existing non-dipping BP. The food intake and BP circadian rhythm changes were associated with alterations in Per2 protein daily oscillation and the time-of-day variations in heart rate variability, baroreflex, and urinary excretion of NE and Epi, and increased mRNA expression of Slc6a2 (encoding NE transporter) and Adra1d (encoding alpha-adrenergic receptor 1d) in the mesenteric resistance arteries, indicating the sympathetic nervous system (SNS) was modulated after light-phase TRF. Collectively, our results demonstrated that light-phase TRF results in reverse dipping of BP in wild-type and diabetic db/db mice and revealed the potential role of the sympathetic pathway in light-phase TRF-induced BP circadian rhythm alteration.

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Section: Introductionsupporting

confidence: 77%

Section: Introductionsupporting

confidence: 77%

Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration

Hou

Chacon

et al. 2022

Front. Nutr.

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“…It should be noted that a recent study in mice showed that the blood pressure rhythm could be inverted by restriction of food intake to the inactive period, and this effect occurred in the absence of changes in the diurnal pattern of urinary sodium excretion ( 104 ). In a pathophysiological setting, it was recently shown that restricting food intake to the active period restored the normal blood pressure rhythm in non-dipping, diabetic mice ( 105 ). In a clinical study, 642 Chinese adults with primary hypertension underwent 24-hour ambulatory blood pressure monitoring, and 24-hour urine sodium excretion was measured along with morning urine sodium concentration ( 106 ).…”

Section: Circadian Disruption In Diseases Of the Human Kidneymentioning

confidence: 99%

Circadian rhythms and renal pathophysiology

Mohandas¹,

Douma²,

Scindia³

et al. 2022

Journal of Clinical Investigation

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The reality of life in modern times is that our internal circadian rhythms are often out of alignment with the light/dark cycle of the external environment. This is known as circadian disruption, and a wealth of epidemiological evidence shows that it is associated with an increased risk for cardiovascular disease. Cardiovascular disease remains the top cause of death in the United States, and kidney disease in particular is a tremendous public health burden that contributes to cardiovascular deaths. There is an urgent need for new treatments for kidney disease; circadian rhythm–based therapies may be of potential benefit. The goal of this Review is to summarize the existing data that demonstrate a connection between circadian rhythm disruption and renal impairment in humans. Specifically, we will focus on chronic kidney disease, lupus nephritis, hypertension, and aging. Importantly, the relationship between circadian dysfunction and pathophysiology is thought to be bidirectional. Here we discuss the gaps in our knowledge of the mechanisms underlying circadian dysfunction in diseases of the kidney. Finally, we provide a brief overview of potential circadian rhythm–based interventions that could provide benefit in renal disease.

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“…Although not directly compared, the hyperacetylation exhibited in the HF diet islet may be partially driven by disruption in the circadian feed-fast cycle which occur with HF feeding ( 159 ). The leptin receptor deficiency model of T2DM (Lepr db/db ), which also exhibits impaired circadian food intake rhythms ( 160 ), similarly exhibits increased H3K27ac and histone H3 lysine 4 monomethylation (H3K4me1; activating chromatin mark which co-occurs with H3K27ac) signal in regions associated with feeding but not in regions associated with fasting. Importantly, regions hyperacetylated are associated with LSD1 binding where it acts as a brake on transcription by demethylating H3K4, likely contributing to β-cell rest ( 161 ).…”

Section: Islet Response To Time-dependent Regulation Of Food Intakementioning

confidence: 99%

It’s What and When You Eat: An Overview of Transcriptional and Epigenetic Responses to Dietary Perturbations in Pancreatic Islets

Brown

Matveyenko

2022

Front. Endocrinol.

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Our ever-changing modern environment is a significant contributor to the increased prevalence of many chronic diseases, and particularly, type 2 diabetes mellitus (T2DM). Although the modern era has ushered in numerous changes to our daily living conditions, changes in “what” and “when” we eat appear to disproportionately fuel the rise of T2DM. The pancreatic islet is a key biological controller of an organism’s glucose homeostasis and thus plays an outsized role to coordinate the response to environmental factors to preserve euglycemia through a delicate balance of endocrine outputs. Both successful and failed adaptation to dynamic environmental stimuli has been postulated to occur due to changes in the transcriptional and epigenetic regulation of pathways associated with islet secretory function and survival. Therefore, in this review we examined and evaluated the current evidence elucidating the key epigenetic mechanisms and transcriptional programs underlying the islet’s coordinated response to the interaction between the timing and the composition of dietary nutrients common to modern lifestyles. With the explosion of next generation sequencing, along with the development of novel informatic and –omic approaches, future work will continue to unravel the environmental-epigenetic relationship in islet biology with the goal of identifying transcriptional and epigenetic targets associated with islet perturbations in T2DM.

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Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice

Cited by 34 publications

References 60 publications

Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration

Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration

Circadian rhythms and renal pathophysiology

It’s What and When You Eat: An Overview of Transcriptional and Epigenetic Responses to Dietary Perturbations in Pancreatic Islets

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