Time-saving synthetic magnetic resonance imaging protocols for pediatric neuroimaging: impact of echo train length and bandwidth on image quality

Lee, So Mi; Cho, Hyun Hae; You, Sun Kyoung; Kim, E; Kim, Seungho; Hwang, Mun Kyung; Cho, Seung Hyun; Park, Byung-Geon; Hong, Joo-Heon; Youn, Sung Won; Chang, Yongmin

doi:10.1007/s00247-022-05389-5

Cited by 1 publication

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lee et al studied SyMRI imaging of healthy neonatal to adolescent brains and found that, except for cortical PD values, T1, T2, and PD values decreased with age. They also provided age-specific reference values as an objective basis for assessing normal/abnormal brain development [ 13 , 19 ]. Vanderhasselt et al reported that neonates with severe postnatal disorders had prolonged local tissue relaxation times, particularly in the PLIC and the central portion of the CS, which had the highest accuracy in predicting at-risk status [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of preoperative brain development in pediatric congenital heart disease patients by synthetic MRI

Xu,

Ma,

Zhang

et al. 2024

Insights Imaging

View full text Add to dashboard Cite

Objectives This study investigated the quantitative assessment and application of Synthetic MRI (SyMRI) for preoperative brain development in children with congenital heart disease (CHD). Methods Forty-three CHD patients aged 2–24 months were prospectively included in the observation group, and 43 healthy infants were included in the control group. The SyMRI scans were processed by postprocessing software to obtain T1, T2, and PD maps. The values of T1, T2, and PD in different brain regions were compared with the scores of the five ability areas of the Gesell Development Scale by Pearson correlation analysis. Results In the observation group, the T1 values of the posterior limb of the internal capsule (PLIC), Optic radiation (PTR), cerebral peduncle, centrum semiovale, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. In the observation group, the T2 values of the PLIC, PTR, frontal white matter, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. Pearson correlation analysis revealed that the observation group had significantly lower Development Scale scores. In the observation group, the T2 value of the splenium of the corpus callosum was significantly positively correlated with the personal social behavior score. The AUCs for diagnosing preoperative brain developmental abnormalities in children with CHD using T1 values of the temporal white matter and dentate nucleus were both greater than 0.60. Conclusions Quantitative assessment using SyMRI can aid in the early detection of preoperative brain development abnormalities in children with CHD. Critical relevance statement T1 and T2 relaxation values from SyMRI can be considered as a quantitative imaging marker to detect abnormalities, allowing for early clinical evaluation and timely intervention, thereby reducing neurodevelopmental disorders in these children. Key Points T1 and T2 relaxation values by SyMRI are related to myelin development. Evaluated development quotient markers were lower in the observation compared to the control group. SyMRI can act as a reference indicator for brain development in CHD children. Graphical Abstract

show abstract

Section: Discussionmentioning

confidence: 99%