Time-Series Analysis of Systolic Blood Pressure Variation in Thirty-Three Uygur Centenarians in China

Kawamura, Hiroshi; Ozawa, Yukio; Jumabay, Medet; Mitsubayashi, Hiromi; Izumi, Yasukatsu; Mahmut, Masum; Ming, Mu Yu; Aisa, Muhebul; Cheng, Zu Heng; Wang, Shi Zhen

doi:10.1291/hypres.26.597

Cited by 12 publications

(5 citation statements)

References 7 publications

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“…5,6 Our results do not support such a conclusion but further indicate that independence does not occur as far as ultradian and 24-hour rhythms in nondippers. Moreover, our results show that in nondipper patients, reduction of 24-hour, 12-hour, and 8-hour SBP and DBP rhythm amplitudes was accompanied by an alteration in the integrity of rhythms.…”

Section: Discussioncontrasting

confidence: 89%

“…2,3 Determination of ultradian components of BP rhythm (ie, those rhythmic components with a period Ͻ24 hours) has often been used as a tool to improve accuracy of the mathematical analysis of 24-hour rhythm parameters. 4 However, because ultradian rhythms have been shown to vary independently of 24-hour rhythms in various situations, 5,6 the possibility arises that their genesis and regulation could be somewhat independent from those regulating 24-hour rhythmicity.…”

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confidence: 99%

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Disruption of Ultradian and Circadian Rhythms of Blood Pressure in Nondipper Hypertensive Patients

et al. 2004

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Abstract-Ultradian rhythms in blood pressure (BP) are known to exist, but their modification in hypertension is largely unknown. The present study was undertaken to assess the integrity of ultradian and 24-hour BP rhythms in dipper (nϭ100) and nondipper (nϭ20) hypertensive patients compared with 44 dipper normotensive individuals. Fourier analysis was used to fit ultradian (12, 8, and 6 hour) and 24-hour rhythms in BP and heart rate (HR). Mesor, amplitude, and acrophase were calculated for individual and overall rhythm curves. All subjects showed significant ultradian or 24-hour BP and HR rhythms. Systolic and diastolic BP mesor was higher in hypertensive patients compared with normotensive patients. The percentage of variability in ambulatory BP that could be explained by fitting ultradian and 24-hour rhythms was reduced in nondippers compared with normotensives or dippers. Amplitude of ultradian and 24-hour rhythms in BP increased in dippers and decreased in nondippers. Ultradian and 24-hour rhythms in HR did not differ among the 3 groups examined. Results indicate that in nondippers, blunted ultradian and 24-hour rhythm amplitude in BP was accompanied by a loss of rhythm integrity. Key Words: blood pressure monitoring, ambulatory Ⅲ human Ⅲ hypertension, arterial Ⅲ circadian rhythm C ircadian rhythm in blood pressure (BP) has been recognized as a prognosis marker in hypertensive patients. 1 In normotensives as well as in noncomplicated hypertensive patients, a significant nocturnal decline in BP occurs, although in hypertensive patients, BP oscillates at a higher level. Nondipper hypertensive patients (ie, those in whom nighttime BP drop is Ͻ10%) have a worse prognosis as a result of increased target organ damage. 2 In this group, significantly greater left ventricular hypertrophy, microalbuminuria, and stroke frequency have been described. 2,3 Determination of ultradian components of BP rhythm (ie, those rhythmic components with a period Ͻ24 hours) has often been used as a tool to improve accuracy of the mathematical analysis of 24-hour rhythm parameters. 4 However, because ultradian rhythms have been shown to vary independently of 24-hour rhythms in various situations, 5,6 the possibility arises that their genesis and regulation could be somewhat independent from those regulating 24-hour rhythmicity.We undertook the present study to compare ultradian rhythm parameters in normotensives and dippers and nondipper hypertensive patients. Because disturbances in 24-hour rhythms were implicated in the physiopathology of hypertension, we also assessed the integrity of 24-hour and ultradian rhythms in the same patient groups. Materials and Methods PatientsAmong 265 patients who underwent ambulatory BP monitoring (ABPM), 180 were included in this study. To be included, each patient's recording should extend for Ն22.5 hours but not Ͼ25.5 hours and with Ͻ5 single measurements missing. Patients were classified as hypertensive if they were under pharmacological treatment or if they showed an average diurnal BP of Ͼ135/ 85...

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Section: Discussioncontrasting

confidence: 89%

mentioning

confidence: 99%

Disruption of Ultradian and Circadian Rhythms of Blood Pressure in Nondipper Hypertensive Patients

et al. 2004

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“…Jones et al (2006) also observed a further fall and rise in systolic blood pressure reactivity in the afternoon. This finding agrees with other observations on elderly people, including those with hypertension, of a secondary rise in blood pressure in the afternoon, especially after a nap is taken (Atkinson et al 1994;Dunbar & Farr 1996;Kawamura et al 2003;Scorzoni et al 1997). Since some cardiac events also show a secondary peak in the late afternoon or evening, these blood pressure changes have led to the hypothesis that daytime sleep or a ''siesta'' is also a significant risk factor for myocardial infarction and strokes (Bursztyn et al 1999(Bursztyn et al , 2002Campos & Siles 2000;Qureshi et al 1997).…”

Section: Quantitative Descriptions Of Heart Rate and Blood Pressure Datasupporting

confidence: 90%

Chronophysiology of the cardiovascular system

Waterhouse

Atkinson

Reilly

et al. 2007

Biological Rhythm Research

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The development of ambulatory blood pressure monitoring devices and the beat-by-beat measurement of heart rate have enabled it to be established that there are circadian rhythms in heart rate and blood pressure in subjects living normally. Investigations of these variables have led to quantification of their fall at night, and rapid rise on awakening and becoming active in the morning. These changes are of particular interest insofar as abnormalities in them are associated with cardiovascular problems and morbidity in patients and also act as risk factors in otherwise healthy individuals. It has also been shown that there are many other variables of the cardiovascular system. The causes of the circadian rhythms in heart rate and blood pressure are outlined, with particular stress upon the role of the autonomic nervous system, as assessed from low-and high-frequency components of the variation in heart rate measured beat-by-beat. Activity increases blood pressure, but there is evidence that this ''reactivity'' varies with time of day, and this also might be related to cardiovascular morbidity. Based upon data from several sources, including night work, resting subjects and bed-ridden patients, it is concluded that the contribution of the ''body clock'' to producing the circadian rhythm in heart rate and blood pressure is relatively small. A bias towards an exogenous cause applies also to most other circadian rhythms in the cardiovascular system. Knowledge of circadian rhythmicity in cardiovascular system, together with an understanding of its causes, provides a rationale for advice to reduce cardiovascular risk and to assess the efficacy of therapies.

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“…We previously observed that healthy children with ultradian rhythmicity have higher overall BP levels than individuals without (10); this effect seemed to be quantitatively similar in the CRF children studied here, although statistical significance was not reached in this smaller cohort. Increased 12-h rhythmicity is also seen together with an increase in BP in very old age (26) and has been linked to primary hypertension in adults with endothelial dysfunction as well as in spontaneously hypertensive rats (27,28). In contrast, the size of the ultradian BP amplitudes was not consistently correlated with mean BP, suggesting that ultradian amplitude changes may arise primarily as a consequence of CRF rather than of hypertension per se.…”

Section: Discussionmentioning

confidence: 99%

Ultradian but not Circadian Blood Pressure Rhythms Correlate with Renal Dysfunction in Children with Chronic Renal Failure

Wühl

Hadtstein

Mehls

et al. 2005

Journal of the American Society of Nephrology

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Whereas the diurnal fall of BP (dipping) is an important prognostic marker in patients with chronic renal failure (CRF), the integrity of physiologic ultradian (i.e., shorter than 24 h) cardiovascular rhythms in patients with CRF is unknown. Also, the relationship between conventional dipping analysis and Fourier spectral rhythm analysis has not been examined in renal hypertension. The prevalence and dimensions of the circadian and three ultradian (12, 8, and 6 h) cardiovascular rhythms were studied by ambulatory BP monitoring in 214 children (aged 3 to 18 yr) with CRF (stage 2 to 4 chronic kidney disease) and no antihypertensive treatment compared with 938 healthy control subjects, and the relationship of rhythm characteristics to conventional dipping parameters, renal function, proteinuria, and serum electrolytes was assessed. The CRF cohort exhibited significantly reduced amplitudes of the circadian and all ultradian cardiovascular rhythms studied (all P < 0.01). Moreover, all BP and most heart rate rhythms showed significantly delayed acrophases (time of peak; P < 0.01). Whereas conventional BP dipping parameters (day/night difference, day/night ratio) and the 24-h BP amplitude were independent of renal function, the 8-h BP amplitude was positively correlated with GFR (r ‫؍‬ 0.3, P ‫؍‬ 0.01) and inversely correlated with the urinary protein/creatinine ratio (r ‫؍‬ ؊0.27, P < 0.05), and the 6-h BP amplitude was inversely correlated with proteinuria (r ‫؍‬ ؊0.3, P < 0.02). Children who displayed 24-or 12-h cardiovascular rhythms had significantly lower serum calcium levels than children without these rhythms. In summary, children with CRF display not only blunted circadian but also blunted ultradian cardiovascular rhythms. Ultradian but not circadian rhythms or conventional dipping parameters are quantitatively associated with renal function and proteinuria.

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Time-Series Analysis of Systolic Blood Pressure Variation in Thirty-Three Uygur Centenarians in China

Cited by 12 publications

References 7 publications

Disruption of Ultradian and Circadian Rhythms of Blood Pressure in Nondipper Hypertensive Patients

Disruption of Ultradian and Circadian Rhythms of Blood Pressure in Nondipper Hypertensive Patients

Chronophysiology of the cardiovascular system

Ultradian but not Circadian Blood Pressure Rhythms Correlate with Renal Dysfunction in Children with Chronic Renal Failure

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