Time-Specific Associations of Tumor Necrosis Factor-α Levels and Polymorphisms (−850 C/T or −308 G/A) With Suicidal Ideation in Acute Coronary Syndrome Patients

Abstract

Background: Considering the association of inflammation with suicide and acute coronary syndrome (ACS), we investigated the individual and interactive effects of serum tumor necrosis factor-alpha (sTNFα) levels and two polymorphisms (−850 C/T and −308 G/A) on suicidal ideation (SI) after ACS.Methods: The SI status using items on the Montgomery–Åsberg Depression Rating Scale (MADRS), related covariates including sociodemographic and clinical characteristics, sTNFα levels, and tumor necrosis factor-alpha (TNF-α) polymorphisms were evaluated in 969 patients within 2 weeks after ACS. Of the patients, 711 were evaluated 1 year later for SI. Multivariate logistic regression models were used to calculate individual and interactive associations after adjusting for the covariates.Results: Higher (vs. lower) sTNFα levels and the −850 C/T or T/T (vs. C/C) polymorphism were significantly associated with SI 2 weeks after ACS, while only higher sTNFα levels were significantly associated with SI after 1 year. Significant interactive effects were detected between sTNFα (higher) levels and the −850 C/T (C/C or C/T) polymorphism on SI 2 weeks after ACS and between the two (−850 CC or CT and −308 G/A or AA) polymorphisms on SI 1 year after ACS.Conclusions: The sTNFα level and two polymorphisms (−850C/T and −308 G/A), separately or in combination, could be time-specific biomarkers for SI in ACS. Focused interventions for ACS patients at risk of SI might reduce the suicidal burden in patients with ACS.

Inflammatory markers in patients who presented with acute coronary syndrome and history of COVID-19 infection: a cross-sectional study

“…33 So, in the case of ACS, the level of TNF-α increased within two weeks after the onset and increased the serum level expression around one year after onset. 34 This is because of the duration of a statins prescription required to decrease TNF-α is from 12 weeks up to 6 months or more, depending on the types of statins and level of lipid profile, 35,36 however, our follow up in this study was only after 1 month.…”

Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review

“…In the second study, SI was associated with the -850 (C/T + T/T) genotype of rs1799724 polymorphism only within the first 2 weeks. The authors also found a significant interaction of -308 G/A and -850 C/T polymorphisms on SI at 1 year after ACS (40). Wang et al (41) studied three polymorphisms, rs361525, rs1800629, and rs1799964, in a post-mortem sample (SCs and controls).…”

“…They reported that the G allele was more 10.3389/fpsyt.2022.1003034 frequent among SAs having made a single attempt compared to controls (38). Kang et al (39,40) conducted two studies on the same cohort to investigate the relationship of SI to TNFα polymorphisms 2 weeks and 1 year after an acute coronary syndrome (ACS). In the first study, a significant association between SI and the -308A allele was found during the acute phase (2 weeks) but it did not persist at the end of follow-up or after Bonferroni correction (39).…”