Time Spent with Saturation below 80% versus 90% in Patients with Obstructive Sleep Apnoea

Bikov, András; Frent, Stefan; Deleanu, Oana; Mészáros, Martina; Birza, Mariela Romina; Popa, Alina Mirela; Manzur, Andrei Raul; Gligor, Loredana; Mihăicuţă, Ştefan

doi:10.3390/jcm12134205

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…These results suggest that the adverse cardiovascular effects of OSA are primarily dependent on the severity of intermittent hypoxia. Deeper hypoxaemia may potentially induce more severe pathophysiological consequences [32]. According to our research data, although PFO failed to affect patients' ODI and minimum oxygen saturation .In the Moderate to Severe group, there were differences in TST90% and T90 between patients with PFO and OSA double-positive and OSA single positive patients.…”

Section: Discussionmentioning

confidence: 44%

Blood oxygen implications of obstructive sleep apnea (OSA) combined with patent foramen ovale (PFO) in Northwest, China

Lv,

Guo,

et al. 2024

Preprint

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Purpose: OSA and PFO both can lead to changes in blood oxygen. In this study, we sought to determine whether blood oxygen changes were further exacerbated with OSA combined with PFO. Methods: Based on c-TCD and PSG results, 623 patients were retrospectively included. According to the results, the patients were divided into 4 groups: OSA and PFO double-positive group, PFO single-positive group, OSA single-positive group, and OSA and PFO double-negative group. In addition, based on the AHI results, we extracted all the severe and moderate patients, and then used the PFO results to group them into the OSA single-positive Moderate-Severe group and the OSA and PFO double-positive Moderate-Severe group. The minimum oxygen saturation, ODI, sleep time with oxygen saturation <90% (TST90) and the percentage of cumulative time with oxygen saturation below 90% in total sleep time(T90) were analysis. Results: The minimum oxygen saturation, ODI: There were statistical differences the four groups (P < 0.000). However, there was no statistical difference between the double-positive group and the OSA single-positive group. At the same time, there was no statistical difference between the PFO single-positive group and the all-negative group either. In addition, there was no statistical difference between the all-positive group and the OSA single-positive group in the Moderate-Severe group. TST90 and T90: There were statistical differences between the OSA single-positive Moderate-Severe group and the OSA and PFO double-positive Moderate-Severe group. Conclusions: Patients with OSA-PFO overlap had more severe intermittent hypoxia during sleep than patients with OSA alone.

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Section: Discussionmentioning

confidence: 44%

Blood oxygen implications of obstructive sleep apnea (OSA) combined with patent foramen ovale (PFO) in Northwest, China

Lv,

Guo,

et al. 2024

Preprint

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“…However, the evaluation of each patient’s unique clinical scenario is imperative. The use of Bi-level PAP should be considered when a patient is unable to tolerate high pressures, when hypoxemia and/or hypoventilation persist despite eliminating obstructive events, and when the patient continues with hypercapnia following three months of CPAP treatment [ 56 , 57 ].…”

Section: Treatmentmentioning

confidence: 99%

“…This classification helped stratify the risk of hypertension in OSA patients. In the case of Mexico City, located at an altitude of 2400 meters above sea level, the threshold for oxygen supplementation is set at a maximum T90 of 30% [ 57 ].…”

Section: Treatmentmentioning

confidence: 99%

Obesity hypoventilation syndrome, literature review

Orozco González,

Rodriguez Plascencia,

Palma Zapata

et al. 2024

Sleep Advances

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Obesity is a global health concern that has been increasing over the years, and it is associated with several pathophysiological changes affecting the respiratory system, including alveolar hypoventilation. Obesity hypoventilation syndrome (OHS) is one of the six subtypes of sleep-hypoventilation disorders. It is defined as the presence of obesity, chronic alveolar hypoventilation leading to daytime hypercapnia and hypoxia, and sleep-disordered breathing. The existence of a sleep disorder is one of the characteristics that patients with OHS present. Among them, 90% of patients have obstructive sleep apnea (OSA), and the remaining 10% of patients with OHS have non-obstructive sleep hypoventilation without OSA or with mild OSA. This review aims to provide a comprehensive understanding of the epidemiological and pathophysiological impact of OHS and to highlight its clinical features, prognosis, and severity, as well as the available treatment options.

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“…Newer research also suggests an increased risk for chronic inflammatory diseases (immuno-suppressive effects) and dementia, the latter of which seems to be related to a loss of function of the so-called glymphatic system [7][8][9][10][11]. A possible common denominator for all of these damaging effects is repeated nocturnal catecholamine-and cortisol-mediated emergency responses triggered by a drop in O 2 saturation [12,13]. In view of the potentially fatal outcome, especially in adults, OSAS is a condition in urgent need of adequate treatment [12].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Mandibular Repositioning Appliance (MARA) on Posterior Airway Space (PAS)

Stamenkovic,

de Araujo Gurgel,

Popovic

et al. 2024

Applied Sciences

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Aim of the study was to show the effect of skeletal Class II treatment with the mandibular anterior repositioning appliance (MARA) on the sagittal posterior airway space (PAS) diameter. A total of 53 patients were selected retrospectively: 26 male patients (median 13 years, age span 10–19 years) and 27 female patients (median 14 years, age span 11–47 years). All patients had lateral cephalograms taken at T1 (before MARA treatment) and at T2 (after MARA treatment). Average treatment took 13.1 ± 7.5 months (Group 1) and 10.5 ± 4.5 months (Group 2), respectively. The following PAS parameters were obtained at T1 and T2: TI (Tangent Point 1), Me/Gn (menton/gnathion), DW (dorsal wall). Additionally, Björk‘s sum angle, SNA, SNB and ANB were determined. The male patients showed a higher increase in the anteroposterior diameter of the PAS (+27.5%) compared to female patients (+11.6%). Male participants had a significantly higher PAS (p = 0.006) than female participants (p = 0.09). Although not significantly, Björk‘s sum angle decreased in both groups. In general, compared to female patients, male patients showed a greater decrease between T1 and T2. SNA and SNB exhibited varied behavior between T1 and T2, with some individuals reporting a decrease and others reporting an increase. SNA tended to decrease in general. In terms of ANB, the male participants displayed a decrease from T1 to T2. Treatment of a skeletal Class II malocclusion with the mandibular anterior repositioning appliance (MARA) caused an increase in the sagittal posterior airway space (PAS) diameter and, thereby, might be effective against obstructive sleep apnea.

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Time Spent with Saturation below 80% versus 90% in Patients with Obstructive Sleep Apnoea

Cited by 6 publications

References 39 publications

Blood oxygen implications of obstructive sleep apnea (OSA) combined with patent foramen ovale (PFO) in Northwest, China

Blood oxygen implications of obstructive sleep apnea (OSA) combined with patent foramen ovale (PFO) in Northwest, China

Obesity hypoventilation syndrome, literature review

Effect of the Mandibular Repositioning Appliance (MARA) on Posterior Airway Space (PAS)

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