Time to death and its predictors among neonates who were admitted to the neonatal intensive care unit at tertiary hospital, Addis Ababa, Ethiopia: Retrospective follow up study

Menalu, Mulat Mossie; Gebremichael, Bereket; Desta, Kalkidan Wondwossen; Kebede, Worku Misganaw; Tarekegn, Fetene Nigussie; Mulu, Getaneh Baye; Atinafu, Bantalem Tilaye

doi:10.3389/fped.2022.913583

Cited by 5 publications

(11 citation statements)

References 24 publications

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“…These results align with a study conducted in the NICU of a tertiary hospital in Addis Ababa (22), where approximately 70% of neonatal deaths were registered during the early neonatal period. Similarly, an investigation conducted in a referral hospital in Cameroon reported that over 74.2% of deaths occurred during the early neonatal period (9).…”

Section: Discussionsupporting

confidence: 90%

“…Likewise, a study conducted in in Addis Ababa (31), which consistently reported a higher likelihood of mortality among neonates with sepsis compared to those without. The presence asphyxia, and respiratory distress syndrome (RDS) were significantly associated with neonatal mortality (43).…”

Section: Discussionmentioning

confidence: 93%

“…Time to death: it is the time from admission at NICU to the occurrence of the outcome/event (discharge/death) (31). It is the time (date) difference between admission and time of event occurred.…”

Section: Event: Neonatal Death After Nicu Admissionmentioning

confidence: 99%

“…A retrospective study conducted in Addis Ababa among neonates found that the overall probability of survival of neonate was about 0. 612 for the follow-up days (22).…”

Section: Introductionmentioning

confidence: 99%

“…A retrospective study conducted in Addis Ababa among neonates found that the overall probability of survival of neonate was about 0. 612 for the follow-up days (22). Furthermore, a study conducted (23) showed, at the end of the follow-up, the cumulative probability of failure was 34.69 per 1000.…”

Section: Introductionmentioning

confidence: 99%

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Time to death and its determinants among neonates admitted to the Neonatal Intensive Care Unit (NICU) of Woldia Comprehensive Specialized Hospital, Amhara region, northeast Ethiopia: A five-year retrospective study

Fentaw,

Demis

2024

Preprint

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Background: Despite an effort to reduce neonatal mortality, Ethiopia is still the leading among the countries with the highest neonatal death. While there have been studies conducted on the overall neonatal mortality rate, there is limited research specifically focusing on the time to death of neonates admitted to the Neonatal Intensive Care Unit (NICU). Objectives: To assess the survival time of neonatal death (time to death) and its determinants for neonates admitted to the NICU of Woldia Comprehensive Specialized Hospital (WCSH). Methods: A retrospective cohort study was conducted among 604 neonates admitted to the NICU of Woldia comprehensive specialized hospital from January 2018 to December 2022. The data were entered using Epi-Data version 4.6 and analysis was made using STATA version 14 software. To estimate failure probability, the Kaplan-Meier curve and life table estimate were calculated. The log-rank test was used to examine differences in death rates among different categories. The Cox proportional hazards model was employed to identify determinant variables. In the multivariate Cox analysis, variables with a hazard ratio p-value < 0.05 were considered statistically significant at a 95% confidence interval. Results: The findings of the study indicate that a total of 604 neonates were included and observed for a cumulative period of 3416 neonate-days. The median time to death among the neonates was 14 days. Out of the reviewed cases, 117 (19.37%) neonates died during the study period. Have no ANC checkup (AHR: 1.68; 95% CI: 1.12-2.52), having bad obstetrics history (AHR: 1.99, 95% CI: 1.28-3.10), having sepsis (AHR: 1.87, 95% CI: 1.23-2.86) and having asphyxia (AHR: 1.64, 95% CI: 1.05-2.58) were increased the hazard of neonatal death. Conclusion: The overall neonatal mortality incidence was high. ANC checkup, bad obstetrics history, and specific diagnoses, were found to significantly influence the hazard of neonatal mortality. Increase awareness and education programs for the community regarding the importance of ANC visits. Implement protocols for early identification and management of respiratory distress, sepsis and prenatal asphyxia is critical.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 93%

Section: Event: Neonatal Death After Nicu Admissionmentioning

confidence: 99%

“…A retrospective study conducted in Addis Ababa among neonates found that the overall probability of survival of neonate was about 0. 612 for the follow-up days (22).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Time to death and its determinants among neonates admitted to the Neonatal Intensive Care Unit (NICU) of Woldia Comprehensive Specialized Hospital, Amhara region, northeast Ethiopia: A five-year retrospective study

Fentaw,

Demis

2024

Preprint

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Incidence and Predictors of Mortality Among Preterm Neonates Admitted to Neonatal Intensive Care Units in Comprehensive Specialized Hospitals in Northeast Ethiopia: A Multi-Center Prospective Follow-Up Study

Birhanu,

Tarekegn,

Endeshaw

et al. 2024

Preprint

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Background Despite numerous efforts, preterm mortality remains a significant public health burden in Ethiopia. Therefore, this study aimed to assess the incidence and predictors of preterm mortality among preterm neonates admitted to Comprehensive Specialized Hospitals in Northeast Ethiopia in 2024. Methods A multi-center prospective follow-up study conducted at the institutional level involved 356 preterm neonates, selected through consecutive sampling. A Weibull proportional hazards model was fitted to identify predictors of preterm neonatal mortality. Result The preterm neonatal mortality rate was 72 per 1,000 person-days of observation. The median time to death was 10 days (IQR = 7–20 days). Predictors of preterm neonatal mortality included young maternal age (15–19 years) [AHR 2.73 (95% CI: 1.3–5.9)], extremely low birth weight [AHR 2.4 (95% CI: 1.24–4.6)], respiratory distress syndrome [AHR 2.3 (95% CI: 1.34–3.8)], early preterm birth [AHR 1.8 (95% CI: 1.1–3)], lack of kangaroo mother care [AHR 2.2 (95% CI: 1.54–3.21)], multiple pregnancy [AHR 2.1 (95% CI: 1.1–4.3)], necrotizing enterocolitis [AHR 1.53 (95% CI: 1.1–2.22)], suboptimal continuous positive airway pressure therapy [AHR 1.43 (95% CI: 1.02–2.02)], and congenital anomalies [AHR 2.3 (95% CI: 1.32–3.9)]. Conclusion The current study revealed that preterm neonatal mortality significantly exceeds the national average and is unacceptably high, necessitating immediate intervention. This underscores the urgency to improve optimal childbearing age, optimize continuous positive airway pressure therapy, improve kangaroo mother care practices, and enhance the management of necrotizing enterocolitis and respiratory distress syndrome.

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Time, cause of early neonatal death, and its predictors among neonates admitted to neonatal intensive care units at Bahir Dar City public hospitals, northwest Ethiopia: a prospective follow-up study

Gessesse,

Belete,

Tadesse

2024

Front. Pediatr.

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BackgroundGlobally, 75% of neonatal deaths occur during the first weeks of life and more than 43% of deaths are covered by sub-Saharan Africa. Health-related policymakers and decision-makers need to use evidence-based treatments to reduce the time to early neonatal death and associated predictors. However, there are limited studies on median survival time, cause, incidence, and predictors in the study area as well as the country. Therefore, the aim of the present study was to assess time, the cause of early neonatal death, and its predictors among neonates admitted to neonatal intensive care units at Bahir Dar City public hospitals in northwest Ethiopia.MethodsAn institution-based prospective follow-up study design was conducted among 387 early neonates selected by systematic sampling between 22 February and 22 April 2023. Statistical software, Epi Data version 4.6 and Stata version 14, was used for entry and analysis, respectively. Proportional hazard assumption and model fitness were checked by the Schoenfeld residual test and the Cox-Snell residual test, respectively. Descriptive statistics, the Kaplan–Meier curve, and the life table were used to describe variables. The Cox regression analysis model was fitted to identify the predictors of early neonatal death.ResultDuring the follow-up time, 59 (15.25%) early neonates died, with an incidence of 31.79 per 1,000 early neonate days [95% confidence interval (CI): 0.024–0.041]. The leading causes of early neonatal death were prematurity complications, asphyxia, sepsis, meconium aspiration syndrome, and necrotizing enterocolitis. The mean survival time was 2.72 days. Being born from a multigravida mother [adjusted hazard ratio (AHR) 4.34; 95% CI: 1.63–11.55], a grand multigravida mother (AHR 3.50; 95% CI: 1.12–10.95), respiratory distress syndrome (AHR 2.60; 95% CI: 1.03–6.58), birth asphyxia (AHR 7.51; 95% CI: 2.30–24.51), a small gestational age (AHR 2.05; 95% CI: 1.08–4.92), and being unable to exclusively breastfeed (AHR 3.46; 95% CI: 1.52–7.88) were significantly associated predictors for time to early neonatal death.Conclusion and recommendationsThe incidence of early neonatal death was high, and the mean survival time was 2.72 days. Gravidity, respiratory distress syndrome, birth asphyxia, and being unable to exclusively breastfeed were identified as predictors of early neonatal death. Therefore, future research will consist of long-term prospective follow-up studies at a multicenter, nationwide level.

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Time to death and its predictors among neonates who were admitted to the neonatal intensive care unit at tertiary hospital, Addis Ababa, Ethiopia: Retrospective follow up study

Cited by 5 publications

References 24 publications

Time to death and its determinants among neonates admitted to the Neonatal Intensive Care Unit (NICU) of Woldia Comprehensive Specialized Hospital, Amhara region, northeast Ethiopia: A five-year retrospective study

Time to death and its determinants among neonates admitted to the Neonatal Intensive Care Unit (NICU) of Woldia Comprehensive Specialized Hospital, Amhara region, northeast Ethiopia: A five-year retrospective study

Incidence and Predictors of Mortality Among Preterm Neonates Admitted to Neonatal Intensive Care Units in Comprehensive Specialized Hospitals in Northeast Ethiopia: A Multi-Center Prospective Follow-Up Study

Time, cause of early neonatal death, and its predictors among neonates admitted to neonatal intensive care units at Bahir Dar City public hospitals, northwest Ethiopia: a prospective follow-up study

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